Results 31 to 40 of about 6,796 (188)

Drug Discovery for Snakebite Envenoming: Wanderings Amid Historical Antidotes and Emerging Therapeutic Opportunities. [PDF]

ChemMedChem
In this review, we provide an overview of selected historical antidotes against snakebite envenomation used in early modern Europe. Then, the evidence‐based antivenom activity of some natural compounds is discussed as resulting from more than two decades of research studies.
Bianconi E, Camaioni E, Oszajca P, Macchiarulo A.   +3 more
europepmc   +2 more sources

VENENO DA Bothrops jararacussu: DA TOXICIDADE AO POTENCIAL FARMACOLÓGICO [PDF]

, 2022
A Jararacuçu (Bothrops jararacussu) é uma víbora bastante venenosa e perigosa, sendo a 2ª maior serpente peçonhenta do Brasil. O presente estudo tem como objetivo, realizar uma revisão sistemática sobre o mecanismo tóxico, manifestações clínicas e o ...
Freire Batista Filho, Glauciano, dos Santos Silva, Richardson, Cristina Lima Nobre de Morais, Arlandia, Cabral Alves Neta, Teresinha, Oliveira Diógenes, Guilherme, Raquel Araripe Lacerda, Luanny, Agostinho Rodrigues, Guilherme, de Andrade Santos, Ingrid, Filho Castro Monteiro, Francinaldo, Gomes de Araújo, Igor   +9 more
core   +1 more source

High‐resolution crystal structure of the Mu8.1 conotoxin from Conus mucronatus

Acta Crystallographica Section F, Volume 79, Issue 9, Page 240-246, September 2023., 2023
The crystal structure of the Mu8.1 conotoxin was determined in the high‐symmetry space group I4122 at 1.67 Å resolution. This crystal structure reveals a surface‐exposed Zn2+‐binding site and establishes a hydrogen‐bonding network around Lys55 buried at the dimer interface.Marine cone snails produce a wealth of peptide toxins (conotoxins) that bind ...
Emilie Müller, Celeste Menuet Hackney, Lars Ellgaard, Jens Preben Morth   +3 more
wiley   +1 more source

Environmental drivers of tropical forest snake phenology: Insights from citizen science

Ecology and Evolution, Volume 13, Issue 7, July 2023., 2023
We used long‐term time‐series data to investigate the environmentally driven changes in the activity patterns of 25 snake species in the Atlantic Forest region of southeastern Brazil. Overall, we found snake activity patterns were largely driven by temperature and humidity, with venomous and non‐venomous species responding differently to climate.
Letízia M. G. Jesus, Jhonny J. M. Guedes, Mario R. Moura, Renato N. Feio, Henrique C. Costa   +4 more
wiley   +1 more source

Anti‐Metalloprotease P‐I Single‐Domain Antibodies: Tools for Next‐Generation Snakebite Antivenoms

BioMed Research International, Volume 2022, Issue 1, 2022., 2022
In order to address the global antivenom crisis, novel antivenoms need to present high therapeutic efficacy, broad neutralization ability against systemic and local damage, sufficient safety, and cost‐effectiveness. Due to biological characteristics of camelid single‐domain antibodies (VHH) such as high affinity, their ability to penetrate dense ...
Marcela C. S. Silva, Soraya S. Pereira, Marilia P. Gouveia, Marcos B. Luiz, Rosa M. O. Sousa, Anderson M. Kayano, Aleff F. Francisco, Nidiane D. R. Prado, Leandro S. M. Dill, Marcos R. M. Fontes, Fernando B. Zanchi, Rodrigo G. Stabeli, Andreimar M. Soares, Juliana P. Zuliani, Carla F. C. Fernandes, Carla F. C. Fernandes   +15 more
wiley   +1 more source

Differences between poison and venom: An attempt at an integrative biological approach

Acta Zoologica, Volume 102, Issue 4, Page 337-350, October 2021., 2021
Abstract We discuss the use of the terms venom and poison, in the context of integrative biology, with particular emphasis on behaviour and natural history. Our purpose is to reach a broad scientific audience, especially that dedicated to zoology. The meaning of the two terms is reviewed from the secretory perspective, mainly focussed on the reptiles ...
Carlos Jared, Pedro Luiz Mailho‐Fontana, Marta Maria Antoniazzi   +2 more
wiley   +1 more source

IgG antibodies against phospholipase A2 from Crotalus durissus terrificus: cross-reaction with venoms from Bothrops species from Argentina

Journal of Venomous Animals and Toxins including Tropical Diseases, 2009
We examined the ability of IgG anti-crotalic PLA2 to cross-react with Bothrops spp. venoms, from snakes found in the northeast of Argentina. Immunoblotting and ELISA tests showed that IgG anti-crotalic PLA2 recognize antigens of bothropic venoms ...
JP Rodríguez, MC De Marzi, S Maruñak, P Teibler, O Acosta, EL Malchiodi, LC Leiva   +6 more
doaj   +1 more source

Hematology, Clinical Biochemistry, and Blood Cell Morphology Features of Captive Bothrops jararaca From Southeast Brazil. [PDF]

Vet Clin Pathol
ABSTRACT Background Snakebite envenomation is a worldwide public health issue, particularly relevant to low and middle‐income countries. Bothrops spp. antivenom is needed for snakebite treatment, which requires the maintenance of healthy snakes in captivity.
Alcantara AO, Reis BMM, Fonseca JG, Sousa MAC, Roxo VHA, Souza GJ, Castro FFA, Souza GN, Fernandes J, Lemos ERS, Souza AM.   +10 more
europepmc   +2 more sources

Behavioral Thermoregulation of Amphibians and Reptiles from Two Brazilian Hotspots

, 2022
The Bulletin of the Ecological Society of America, Volume 103, Issue 2, April 2022.
Juan C. Díaz‐Ricaurte, Filipe C. Serrano, Marcio Martins   +2 more
wiley   +1 more source

Photobiomodulation Protects and Promotes Differentiation of C2C12 Myoblast Cells Exposed to Snake Venom. [PDF]

PLoS ONE, 2016
BACKGROUND:Snakebites is a neglected disease and in Brazil is considered a serious health problem, with the majority of the snakebites caused by the genus Bothrops. Antivenom therapy and other first-aid treatments do not reverse local myonecrose which is
Luciana Miato Gonçalves Silva, Camila Aparecida Alves da Silva, Aline da Silva, Rodolfo Paula Vieira, Raquel Agnelli Mesquita-Ferrari, José Carlos Cogo, Stella Regina Zamuner   +6 more
doaj   +1 more source