Results 1 to 10 of about 975 (184)

Synergism between basic Asp49 and Lys49 phospholipase A2 myotoxins of viperid snake venom in vitro and in vivo. [PDF]

PLoS ONE, 2014
Two subtypes of phospholipases A2 (PLA2s) with the ability to induce myonecrosis, 'Asp49' and 'Lys49' myotoxins, often coexist in viperid snake venoms. Since the latter lack catalytic activity, two different mechanisms are involved in their myotoxicity ...
Diana Mora-Obando, Julián Fernández, Cesare Montecucco, José María Gutiérrez, Bruno Lomonte   +4 more
doaj   +3 more sources

Short Linear Motifs Characterizing Snake Venom and Mammalian Phospholipases A2 [PDF]

Toxins, 2021
Snake venom phospholipases A2 (PLA2s) have sequences and structures very similar to those of mammalian group I and II secretory PLA2s, but they possess many toxic properties, ranging from the inhibition of coagulation to the blockage of nerve ...
Caterina Peggion, Fiorella Tonello
doaj   +2 more sources

Role of enzymatic activity in muscle damage and cytotoxicity induced by Bothrops asper Asp49 phospholipase A2 myotoxins: are there additional effector mechanisms involved? [PDF]

PeerJ, 2014
Viperid venoms often contain mixtures of Asp49 and Lys49 PLA2 myotoxin isoforms, relevant to development of myonecrosis. Given their difference in catalytic activity, mechanistic studies on each type require highly purified samples.
Diana Mora-Obando, Cecilia Díaz, Yamileth Angulo, José María Gutiérrez, Bruno Lomonte   +4 more
doaj   +4 more sources

Angiogenesis precedes myogenesis during regeneration following biopsy injury of skeletal muscle [PDF]

Skeletal Muscle, 2023
Background Acute injury to skeletal muscle damages myofibers and fragment capillaries, impairing contractile function and local perfusion. Myofibers and microvessels regenerate from satellite cells and from surviving microvessel fragments, respectively ...
Nicole L. Jacobsen, Aaron B. Morton, Steven S. Segal   +2 more
doaj   +2 more sources

In Vitro neurotoxicity and myotoxicity of Malaysian Naja sumatrana and Naja kaouthia venoms: Neutralization by monovalent and Neuro Polyvalent Antivenoms from Thailand. [PDF]

PLoS ONE, 2022
Naja sumatrana and Naja kaouthia are medically important elapids species found in Southeast Asia. Snake bite envenoming caused by these species may lead to morbidity or mortality if not treated with the appropriate antivenom.
Nor Asyikin Zukifli, Zalikha Ibrahim, Iekhsan Othman, Ahmad Khaldun Ismail, Janeyuth Chaisakul, Wayne C Hodgson, Muhamad Rusdi Ahmad Rusmili   +6 more
doaj   +2 more sources

Snake venom defensins: Defining the structural and functional characteristics of the toxin family [PDF]

Journal of Structural Biology: X
Snake venom defensins are a toxin family found in rattlesnake venoms (Crotalus) which are comprised of crotamine-like peptides and myotoxins. Their tertiary structure resembles the β-defensin family structure.
David Melendez-Martinez, Adriana Morales-Martinez, Iliana Vanessa Almanza-Campos, Francisco Sierra-Valdez, Miguel Borja, Alejandro Carbajal-Saucedo, Christopher L. Parkinson, Jorge Benavides   +7 more
doaj   +2 more sources

Tissue damaging toxins in snake venoms: mechanisms of action, pathophysiology and treatment strategies [PDF]

Communications Biology
Snakebite envenoming is an important public health issue responsible for mortality and severe morbidity. Where mortality is mainly caused by venom toxins that induce cardiovascular disturbances, neurotoxicity, and acute kidney injury, morbidity is caused
Mátyás A. Bittenbinder, Jory van Thiel, Fernanda C. Cardoso, Nicholas R. Casewell, José-María Gutiérrez, Jeroen Kool, Freek J. Vonk   +6 more
doaj   +2 more sources

Isolation and structural characterization of bioactive compound from Aristolochia sprucei aqueous extract with anti-myotoxic activity [PDF]

Toxicon: X, 2020
A bioactive compound isolated from the stem extract of Aristolochia sprucei through High Performance Liquid Chromatography (HPLC) was identified via Nuclear Magnetic Resonance (NMR) as the aristolochic acid (AA). This compound showed an inhibitory effect
Isela I. González Rodríguez, Aleff F. Francisco, Leandro S. Moreira-Dill, Aristides Quintero, César L.S. Guimarães, Carlos A.H. Fernandes, Agnes A.S. Takeda, Fernando B. Zanchi, Cléopatra A.S. Caldeira, Paulo S. Pereira, Marcos R.M. Fontes, Juliana P. Zuliani, Andreimar M. Soares   +12 more
doaj   +2 more sources

Phospholipase A2 Myotoxins From Bothrops Snake Venoms

Toxicon, 1995
Several myotoxins have been isolated from Bothrops snake venoms during the last 10 years. All of them are group II basic phospholipases A2, although some lack enzymatic activity (i.e. Lys-49 variants). These myotoxins appear as an antigenically related family of proteins occurring in many, but not all, Bothrops venoms, bearing a close structural and ...
José María Gutiérrez, Bruno Lomonte, Josémaria Gutierrez   +2 more
exaly   +4 more sources

Localization of Myotoxin I and Myotoxin II from the venom of Bothrops asper in a murine model

Toxicon, 2021
Phospholipases A2 (PLA2s) and PLA2-like proteins are significant components of snake venoms. Some of these proteins act as potent toxins causing muscle necrosis, which may lead to amputation in severe envenomings. Fundamental aspects of the mechanism of action of these toxins are still not completely known.
Sofía Vargas-Valerio, Joby Robleto, Stephanie Chaves-Araya, Laura Monturiol-Gross, Bruno Lomonte, Fiorella Tonello, Julián Fernández   +6 more
openaire   +4 more sources