Results 21 to 30 of about 975 (184)
Scientific Reports, 2021 Viperid snake venoms contain a unique family of cytotoxic proteins, the Lys49 PLA2 homologs, which are devoid of enzymatic activity but disrupt the integrity of cell membranes.
Alfredo Jesús López-Dávila +7 more
doaj +1 more source
Transcriptomic Insights Into the Evolution of Snake Venom: Mechanisms, Diversity, and Adaptation. [PDF]
Scientifica (Cairo)Snake venoms are evolutionarily refined biochemical arsenals composed of diverse toxins with complex functional roles in predation, defense, and competition. Over the past 2 decades, transcriptomic approaches have transformed venom research by enabling high‐resolution insights into gene expression dynamics, molecular diversity, and the evolutionary ...
Sofyantoro F +13 more
europepmc +2 more sources
Clinical management of snakebite envenoming: Future perspectives
Toxicon: X, 2021 Snakebite envenoming is a major cause of morbidity and mortality in rural communities throughout the tropics. Generally, the main clinical features of snakebites are local swelling, tissue necrosis, shock, spontaneous systemic hemorrhage, incoagulable ...
Muhammad Hamza +6 more
doaj +1 more source
Lys49 myotoxins, secreted phospholipase A2-like proteins of viperid venoms: a comprehensive review
, 2023 Muscle necrosis is a potential clinical complication of snakebite envenomings, which in severe cases can lead to functional or physical sequelae such as disability or amputation.
Lomonte, Bruno, Bruno Lomonte
core +1 more source
A single-step purification of bothropstoxin-1
Brazilian Journal of Medical and Biological Research, 1998 Bothrops venoms are complex mixtures of components with a wide range of biological activities. Among these substances, myotoxins have been investigated by several groups.
P.J. Spencer +4 more
doaj +1 more source
A myotoxin secreted by some piscivorousConusspecies [PDF]
British Journal of Pharmacology, 1972 Summary. Toxins isolated from the venom apparatus ofConus magusandConus achatinushave the same pharmacological properties, but differ from the toxins of several other piscivorous species of cone shells..C. magusandC. achatinustoxins are heat labile at pH 8·5.
S E, Freeman, R J, Turner
openaire +2 more sources
Frontiers in Molecular Biosciences, 2022 DM64 is a toxin-neutralizing serum glycoprotein isolated from Didelphis aurita, an ophiophagous marsupial naturally resistant to snake envenomation. This 64 kDa antitoxin targets myotoxic phospholipases A2, which account for most local tissue damage of ...
Barbara S. Soares +18 more
doaj +1 more source
Low-Level Laser Therapy (904 nm) Counteracts Motor Deficit of Mice Hind Limb following Skeletal Muscle Injury Caused by Snakebite-Mimicking Intramuscular Venom Injection. [PDF]
PLoS ONE, 2016 Myotoxins present in Bothrops venom disrupt the sarcolemma of muscle fibers leading to the release of sarcoplasmic proteins and loss of muscle homeostasis.
Willians Fernando Vieira +4 more
doaj +1 more source
Ontogenetic Change in the Venom of Mexican Black-Tailed Rattlesnakes (Crotalus molossus nigrescens)
Toxins, 2018 Ontogenetic changes in venom composition have important ecological implications due the relevance of venom in prey acquisition and defense. Additionally, intraspecific venom variation has direct medical consequences for the treatment of snakebite ...
Miguel Borja +10 more
doaj +1 more source
Snake Venom Hemotoxic Enzymes: Biochemical Comparison between Crotalus Species from Central Mexico
Molecules, 2019 Snakebite envenoming is a serious medical problem in different areas of the world. In Latin America, the major prevalence is due to snakes of the family Viperidae, where rattlesnakes (Crotalus) are included.
Octavio Roldán-Padrón +7 more
doaj +1 more source