Results 31 to 40 of about 975 (184)

Geigerin-induced cytotoxicity in a murine myoblast cell line (C2C12)

Onderstepoort Journal of Veterinary Research, 2017
Geigeria poisoning in sheep, locally known as ‘vermeersiekte’, is an economically important plant poisoning in southern Africa. The toxic principles contained by the toxic plants are believed to be several sesquiterpene lactones, such as geigerin ...
Christo J. Botha, Sarah J. Clift, Gezina C.H. Ferreira, Mxolisi G. Masango   +3 more
doaj   +1 more source

POTENTIAL ANTIDOTE TO SNAKE VENOM MYOTOXIN [PDF]

Journal of Experimental Biology, 2012
![][1] Snakebites are frequently hazardous accidents that require immediate medical treatment to neutralize the venom’s toxic effects. A feared complication of South American pit viper bites is extended myonecrosis, i.e.
openaire   +1 more source

Bp-13 PLA2: Purification and Neuromuscular Activity of a New Asp49 Toxin Isolated from Bothrops pauloensis Snake Venom

Biochemistry Research International, 2015
A new PLA2 (Bp-13) was purified from Bothrops pauloensis snake venom after a single chromatographic step of RP-HPLC on μ-Bondapak C-18. Amino acid analysis showed a high content of hydrophobic and basic amino acids and 14 half-cysteine residues.
Georgina Sucasaca-Monzón, Priscila Randazzo-Moura, Thalita Rocha, Frank Denis Torres-Huaco, Augusto Vilca-Quispe, Luis Alberto Ponce-Soto, Sérgio Marangoni, Maria Alice da Cruz-Höfling, Léa Rodrigues-Simioni   +8 more
doaj   +1 more source

Contextually conspicuous species are more likely to be venomous: Habitat‐dependent aposematic colouration found throughout snakes

Journal of Animal Ecology, Volume 95, Issue 11, Page 2322-2334, November 2026.
Conspicuous colouration signals venomous nature throughout snakes. Abstract Many animals use conspicuous colours to advertise their unprofitability to potential predators, a phenomenon known as aposematism. For example, conspicuous banded patterns in snakes are often highlighted as aposematic signalling of their venomous nature.
Amy Duclaux, Michel Dugon, Kevin Healy
wiley   +1 more source

Calcium ion independent membrane leakage induced by phospholipase-like myotoxins

, 1992
The two snake venom myotoxins ammodytin L and myotoxin II, purified respectively from Vipera ammodytes ammodytes and Bothrops asper, have phospholipase-like structures but lack an Asp-49 in the active site and are without normal phospholipase activity ...
MASSOUD, RENATO, Rufini, S, LULY, PAOLO, Gubensek, F, PEDERSEN, JENS ZACHO, Cesaroni, P, Massoud, R., DESIDERI, ALESSANDRO, Luly, P, Desideri, A, Gutiérrez, J, RUFINI, STEFANO, Farias, R., Luly, P., Massoud, R, Cesaroni, P., Morero, R., Desideri, A., Farias, R, Morero, R, Gutiérrez, José María, Pedersen, J. Z., Pedersen, J, Gubensek, F.   +23 more
core   +1 more source

Quantitative MRI Assessment of Myotoxin‐Induced Skeletal Muscle Damage of mdx Mice

Muscle &Nerve, Volume 74, Issue 2, Page 485-491, August 2026.
ABSTRACT Introduction/Aims Although magnetic resonance imaging (MRI) has been extensively applied in dystrophic muscle, longitudinal characterization of multiple quantitative MRI parameters during degeneration and regeneration remains limited. This study aimed to longitudinally characterize changes in quantitative MRI parameters in control and ...
Ravneet Vohra, Joshua Park, Feng Zhang, Jeffrey S. Chamberlain, Donghoon Lee   +4 more
wiley   +1 more source

Engineering Antivenom: Research Progress and Future Directions in Snakebite Envenoming Therapy

Annals of the New York Academy of Sciences, Volume 1562, Issue 1, August 2026.
Snakebite envenoming therapy is evolving from plasma‐derived antivenoms toward rationally engineered therapeutics. Advances in toxicovenomics, structural biology, antibody engineering, computational protein design, recombinant expression, small‐molecule inhibitors, and diagnostics are enabling toxin‐centric development of safer, more effective, and ...
Andreas H. Laustsen
wiley   +1 more source

General characterization of venom from the Moroccan snakes Macrovipera mauritanica and Cerastes cerastes

Journal of Venomous Animals and Toxins including Tropical Diseases, 2012
Ophidian envenomation accidents constitute a serious public health problem in many countries around the globe. Over 5 million such accident cases occur each year causing more than 100,000 deaths. In Africa, more than 20,000 deaths per year are registered
N Oukkache, M Lalaoui, N Ghalim
doaj   +1 more source

De Novo Multi‐Mechanism Antimicrobial Peptide Design via Multimodal Deep Learning

Advanced Science, Volume 13, Issue 28, 18 May 2026.
Current AI‐driven peptide discovery often overlooks complex structural data. This study presents M3‐CAD, a generative pipeline that leverages 3D voxel coloring and a massive database of over 12 000 peptides to capture nuanced physicochemical contexts.
Xiaojuan Li, Haifan Gong, Yue Wang, Yinuo Zhao, Lixiang Li, Peijing Bao, Qingzhou Kong, Jialu Fu, Boyao Wan, Yumeng Zhang, Jinghui Zhang, Jiekun Ni, Zhongxue Han, Xueping Nan, Kunping Ju, Longfei Sun, Yuerui Ma, Huijun Chang, Mengqi Zheng, Yanbo Yu, Xiaoyun Yang, Xiuli Zuo, Haina Wang, Yanqing Li   +23 more
wiley   +1 more source

Structural basis of the myotoxic inhibition of the Bothrops pirajai PrTX-I by the synthetic varespladib

, 2023
Varespladib (LY315920) is a potent inhibitor of human group IIA phospholipase A2 (PLA2) originally developed to control inflammatory cascades of diseases associated with high or dysregulated levels of endogenous PLA2. Recently, varespladib was also found
Ortolani, Paula L., Fortes-Dias, Consuelo L., Salvador, Guilherme H.M. [UNESP], Fontes, Marcos Roberto de Mattos, Fontes, Marcos R.M. [UNESP], Soares, Andreimar M., Soares, Adreimar M., Forte Dias, Consuelo L., Cavalcante, Walter L. G., Cavalcante, Walter L.G., Lewin, Matthew R., Salvador, Guilherme Henrique Marchi, Pinto, Êmylle K. R., Lomonte, Bruno, Pinto, Êmylle K.R.   +14 more
core   +1 more source