Results 51 to 60 of about 975 (184)

Spatially Resolved Profiling of Compartmentalized Muscle and Brain Inflammation

European Journal of Immunology, Volume 55, Issue 12, December 2025.
This review summarizes emerging spatially resolved multi‐omics approaches revealing organized cell–cell interactions in skeletal muscle and brain inflammation. These tools uncover radiating molecular programs and niche‐specific immunopathology that shape cellular reactivity and vulnerability.
Thorge Dobbertin, Lucas Schirmer
wiley   +1 more source

Comparative biochemical studies of myotoxic phospholipase A(2) from Bothrops venom

, 2001
Venoms from Bothrops jararacussu, Bothrops asper, Bothrops atrox, Bothrops pirajai, Bothrops moojeni, Bothrops alternatus and Bothrops (Bothriopsis) bilineata were fractionated using a simplified procedure based on ion-exchange chromatography on CM ...
Marangoni, S., Novello, J. C., Fontes, MRM, Andriao-Escarso, S. H., Toyama, M. H., Oliveira, B., Soares, A. M., Giglio, JR   +7 more
core   +2 more sources

The Effect of Anti‐3‐Hydroxy‐3‐Methylglutaryl‐CoA Reductase (HMGCR) Human Autoantibodies on Muscle Regeneration in Mice

Muscle &Nerve, Volume 72, Issue 6, Page 1300-1308, December 2025.
ABSTRACT Introduction/Aims Anti‐3‐hydroxy‐3‐methylglutaryl‐CoA reductase (HMGCR) autoantibodies (aAbs) are pathogenic in immune‐mediated necrotizing myopathy (IMNM), partly through complement activation. C5 inhibition did not restore muscle strength in mice or patients with overt IMNM, suggesting additional pathogenic mechanisms.
Sarah Julien, Honorine Tomasevic, Thara Jaworski, Rachid Zoubairi, Jeremie Martinet, Laurent Drouot, Olivier Boyer   +6 more
wiley   +1 more source

The C-terminal region of a Lys49 myotoxin mediates Ca(2+) influx in C2C12 myotubes.

, 2010
Myotoxins are abundant components of snake venoms, being a significant public health problem worldwide. Among them, Lys49 phospholipase A(2) homologue myotoxins cause extensive necrosis in skeletal muscle tissue.
PIZZO, PAOLA, Angulo Ugalde, Yamileth, GUTIERREZ JM, MONTECUCCO, CESARE, Cintra Francischinelli, Mariana, Lomonte, Bruno, ANGULO Y, CINTRA FRANCISCHINELLI M, LOMONTE B., Gutiérrez, José María, Bruno Lomonte, Cesare Montecucco, José M. Gutiérrez, Paola Pizzo, Mariana Cintra-Francischinelli, Yamileth Angulo   +15 more
core   +1 more source

Biochemical characterization and pharmacological properties of a phospholipase A2 myotoxin inhibitor from the plasma of the snake Bothrops asper [PDF]

, 1997
A protein that neutralizes the biological activities of basic phospholipase A2 (PLA2) myotoxin isoforms from the venom of the snake Bothrops asper was isolated from its blood by affinity chromatography with Sepharose-immobilized myotoxins.
Lizano González, Sergio, Lomonte, Bruno, Fox, Jay W., Gutiérrez, José María   +3 more
core   +1 more source

Predation Strategies of the Portuguese Man‐of‐War Physalia physalis

Marine Ecology, Volume 46, Issue 6, November/December 2025.
ABSTRACT The Portuguese man‐of‐war Physalia physalis is widely known for causing poisoning on human beings. Physalia physalis is mostly described as a predator of fish eggs and larvae. Here, we report for the first time that large fish can also be preyed by P. physalis.
Jorge L. S. Nunes, Diego S. Campos, Héllida Negrão Dias, Luiz P. N. e Silva, Denise M. R. F. Bastos, Tommaso Giarrizzo, Allan Jamesson Silva de Jesus, Jamerson Aguiar‐Santos, Ana Catarina Miranda   +8 more
wiley   +1 more source

Pathogenesis of myonecrosis induced by crude venom and a myotoxin of Bothrops asper

Experimental and Molecular Pathology, 1984
The pathogenesis of skeletal muscle necrosis induced by crude Bothrops asper venom and isolated myotoxic phospholipase was studied using light and electron microscopy. White mice were injected intramuscularly with a dose of 2.5 micrograms/g and tissue samples were taken at 30 min and 1, 3, 6, 12, 24, and 48 hr.
Ownby, Charlotte L., Odell, George V., Gutiérrez, José María   +2 more
openaire   +4 more sources

Pharmacological modulation of edema induced by Lys-49 and Asp-49 myotoxic phospholipases A2 isolated from the venom of the snake Bothrops asper (terciopelo)

, 1998
The pharmacological modulation of edema-forming activity of Bothrops asper myotoxins II and III, Lys-49 and Asp-49 phospholipases A2, respectively, was studied plethysmographically in the mouse foot pad model.
León, Georgina, Alvarado, Victor Hugo, Gutiérrez, José María, Chaves Mora, Fernando, Fernando Chaves, José Marı́a Gutiérrez, Georgina León, Vı́ctor Hugo Alvarado   +7 more
core   +1 more source

Melatonin Activates AMPK Pathway to Regulate the Regeneration of Slow Muscle Fibers in Skeletal Muscle Injury Repair

The FASEB Journal, Volume 39, Issue 20, 31 October 2025.
The figure illustrates in vitro (melatonin‐treated C2C12 myoblasts) and in vivo (mouse frostbite‐induced tibialis anterior muscle injury with melatonin administration) models. Melatonin activates AMPK, which phosphorylates PGC‐1α to enhance mitochondrial bioenergetics (decreased ROS and LDH, increased ATP, mtDNA, membrane potential, and oxygen ...
Wei Xie, Zhengchao Hong, Yuxin Xie, Kangyan Hou, Songhan Li, Mingxin Fang, Yupeng Guan, Zhixuan Zhang, Miao Zhang   +8 more
wiley   +1 more source

Serum Proteinogram in the Free‐Living Brazilian Common Opossum (Didelphis aurita)

ELECTROPHORESIS, Volume 46, Issue 18, Page 1447-1454, September 2025.
ABSTRACT Didelphis aurita is a synanthropic marsupial widely distributed in southeastern Brazil, known for its resistance to venom and its relevance in biomedical research. This study aimed to characterize the serum proteinogram of free‐living D. aurita individuals.
Andrés Mauricio Ortega Orozco, Lucas Drumond Bento, Pollyanna Cordeiro Souto, Fabrícia Modolo Girardi, Verônica Rodrigues Castro, João Vitor Gonçalves de Oliveira, Camilo José Ramirez Lopez, Edvaldo Barros, Artur Kanadani Campos, Leandro Abreu da Fonseca   +9 more
wiley   +1 more source