Results 61 to 70 of about 975 (184)
Renal lesions in rhabdomyolysis caused by Pseudechis australis snake myotoxin
Kidney International, 1997 The renal lesions at various time intervals after i.m. injection of Pseudechis australis myotoxin (PA myotoxin) causing myoglobinuria in mice was studied. Biochemical assay of serum creatine phosphokinase (CK) and lactate dehydrogenase (LDH) showed marked elevations [7166 +/- 2064 IU and 1626 +/- 211 Berger-Broida U/ml (B-B U/ml)] six hours after ...
Ponraj, D., Gopalakrishnakone, P.
openaire +2 more sources
Synapse, Volume 79, Issue 4, July 2025.A neuromuscular junction (NMJ) imaged with pre‐ and postsynaptic features seen with immunofluorescent staining along with confocal microscopy. The article presented here confirms the importance of regaining proper posttraumatic NMJ structure to enable reestablishment of healthy skeletal muscle mass and how the presence of mitochondrial matter promotes ...
Michael R. Deschenes +7 more
wiley +1 more source
Discovery of peptidic anti-myotoxins [PDF]
, 2016 More than 2.5 millions envenomations and 125.000 death occur each year due to snakebite. Current antivenoms consist of immunoglobulinesderived from animals, and they are therefore associated with a high risk of adverse reactions in humans. The use of synthetic peptidic antitoxinsmay lead to safer and more effective antivenoms. This research reports the
Bjärtun, Johanna +4 more
openaire
Antibody neutralization of a myotoxin from the venom of Bothrops asper (terciopelo)
Toxicon, 1987 Neutralization of biological activities of B. asper myotoxin by a monospecific anti-myotoxin rabbit serum and polyvalent antivenom was studied. Both antisera neutralized myotoxic, phospholipase A and lethal activities of myotoxin, whereas edema-forming activity of myotoxin was not neutralized by these antisera.
Lomonte, Bruno +3 more
openaire +4 more sources
Separation of two myotoxins from nematocysts of the box jellyfish (Chironex fleckeri)
, 1987 Two myotoxins, both lethal to mice by i.v. injection, were obtained by chromatography on Sephadex G-200 of material released from isolated microbasic mastigophores of C. fleckeri. Both toxins elicit contractures of skeletal (diaphragm) musculature of the
Endean R.
core +1 more source
The FASEB Journal, Volume 38, Issue 22, 30 November 2024.Optogenetic tools like Channelrhodpsin‐2 (ChR2) are useful for inducing skeletal muscle contraction using blue light. However, the prevalence of fluorescent proteins like EYFP may cause functional issues. Here, Lamia et al. showed that the contractile properties of ChR2‐EYFP skeletal muscle had aggregated EYFP in sarcolemma, decreased contractile force
Syeda N. Lamia +13 more
wiley +1 more source
Physiological Reports, Volume 12, Issue 18, September 2024.Abstract The use of tobacco cigarettes produces locomotor muscle weakness and fatigue intolerance. Also, smokers and chronic obstructive pulmonary disease patients have a greater incidence of muscle injury and a deficient myogenic response. However, the effects of smoke exposure on the recovery from eccentric exercise‐induced muscle injuries are ...
Nicole E. Stevens +6 more
wiley +1 more source
Snake venom toxins: Potential anticancer therapeutics
Journal of Applied Toxicology, Volume 44, Issue 5, Page 666-685, May 2024.Abstract Snake venom contains a cocktail of compounds dominated by proteins and peptides, which make up the toxin. The toxin components of snake venom attack several targets in the human body including the neuromuscular system, kidney and blood coagulation system and cause pathologies. As such, the venom toxins can be managed and used for the treatment
Benedict C. Offor, Lizelle A. Piater
wiley +1 more source
Inhibitory effect of fucoidan on the activities of crotaline snake venom myotoxic phospholipases A2
, 2003 Myotoxic phospholipases A2 account for most of the muscle necrosis that results from envenenomation by crotaline snakes. In this study, we investigated the protective effect of fucoidan, a natural sulfated polysaccharide obtained from the brown seaweed ...
Angulo Ugalde, Yamileth, Lomonte, Bruno
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, 2014 Venomous and non-venomous snakes possess phospholipase A(2) (PLA(2)) inhibitory proteins (PLIs) in their blood serum. This study shows the expression and biochemical and functional characterization of a recombinant alpha inhibitor from Bothrops ...
Santos-Filho, Norival A. +27 more
core +1 more source