Results 41 to 50 of about 975 (184)

Fibro‐Adipogenic Progenitors Regulate Orofacial Neuromuscular Junction Regeneration via Myostatin

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 2, April 2026.
ABSTRACT Background Orofacial and limb muscles differ in embryonic origin and regenerative capacity. Neuromuscular junction (NMJ) regeneration is critical for muscle restoration both histologically and functionally. The relative potential of orofacial and limb muscles to form postsynaptic apparatuses remains elusive.
Ruizhi Li, Ruojing Liu, Yixuan Huang, Yijue Wang, Xu Cheng, Jingtao Li, Shujuan Zou, Xing Yin   +7 more
wiley   +1 more source

Cartoon representation of the hypothetical synergistic mechanism involved in the membrane-damaging activity of Asp49 and Lys49 myotoxins.

, 2014
Toxins bind to the muscle cell membrane (A), although acceptor moieties for this event are unknown. Each toxin type by its own has the ability to induce cytotoxicity in vitro or myonecrosis in vivo through membrane damage. Asp49 myotoxins destabilize the
Bruno Lomonte (181809), Diana Mora-Obando (640895), Julián Fernández (5660767), José María Gutiérrez (62868), Cesare Montecucco (181820)   +4 more
core   +1 more source

Association Between Abnormal DNA Methylation and Altered Transcriptome in Muscle Five Years After Critical Illness

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 1, February 2026.
ABSTRACT Background Critically ill patients requiring intensive care unit (ICU) admission suffer from muscle weakness that persists for years. Recently, altered RNA expression was documented in muscle of former ICU patients 5 years after critical illness that suggested disrupted mitochondrial function, disturbed lipid metabolism and fibrosis, of which ...
Ceren Uzun Ayar, Fabian Güiza, Inge Derese, Greet Van den Berghe, Ilse Vanhorebeek   +4 more
wiley   +1 more source

Structural and functional studies of a bothropic myotoxin complexed to rosmarinic acid: new insights into Lys49-PLA₂ inhibition.

PLoS ONE, 2011
Snakebite envenoming is an important public health problem in many tropical and subtropical countries, and is considered a neglected tropical disease by the World Health Organization.
Juliana I Dos Santos, Fábio F Cardoso, Andreimar M Soares, Maeli Dal Pai Silva, Márcia Gallacci, Marcos R M Fontes   +5 more
doaj   +1 more source

CRYSTALLIZATION AND PRELIMINARY DIFFRACTION DATA OF 2 MYOTOXINS ISOLATED FROM THE VENOMS OF BOTHROPS-ASPER (TERCIOPELO) AND BOTHROPS-NUMMIFER (JUMPING VIPER)

, 1993
Two myotoxins isolated from B. asper (myotoxin II) and B. nummifer (myotoxin I) snake venoms have been crystallized and their diffraction properties are described. These myotoxins are phospholipase A2 variants which lack enzymatic activity; B.
Arni, Raghuvir K., Arni, R. K., Gutierrez, J. M., Gutiérrez, José María   +3 more
core   +1 more source

Unveiling the Leishmanicidal Mechanism of 4‐Nerolidylcatechol Isolated From Piper peltatum Against Leishmania infantum

Chemistry &Biodiversity, Volume 23, Issue 1, January 2026.
ABSTRACT The present study assessed the leishmanicidal activity of 4‐nerolidylcatechol (4‐NC) (1) isolated from Piper peltatum leaves against promastigotes and amastigotes of Leishmania amazonensis, L. braziliensis, and L. infantum. The plant was fractionated, leading to the isolation and chemical identification of 4‐NC (1). Biochemical techniques were
Fabiana Brusco Lorenzetti, Rodolfo Bento Balbinot, Danielle Lazarin‐Bidóia, Viviane dos Santos Faiões, Eduardo Caio Torres‐Santos, Celso Vataru Nakamura, Tânia Ueda‐Nakamura, Diógenes Aparício Garcia Cortez, Benedito Prado Dias Filho   +8 more
wiley   +1 more source

Differential susceptibility of C2C12 myoblasts and myotubes to group II phospholipase A2 myotoxins from crotalid snake venoms

, 2005
Group II phospholipase A2 (PLA2) myotoxins isolated from Viperidae/Crotalidae snake venoms induce a rapid cytolytic effect upon diverse cell types in vitro.
Angulo Ugalde, Yamileth, Lomonte, Bruno
core   +1 more source

Animal Venoms as Peptide Libraries for the Discovery of Antiglioblastoma Agents

Biochemistry Research International, Volume 2026, Issue 1, 2026.
Glioblastoma is one of the most aggressive and widely recognized types of brain tumors, characterized by significant cellular and molecular diversity and an inherently aggressive nature. The treatment remains highly challenging, with limited effectiveness and persistently low survival rates.
Livia Ramos Santiago, Edgar Alejandro Pinos Tamayo, Daniel Moreira dos Santos, Bonglee Kim, José R. Almeida, Rosy Iara Maciel de Azambuja Ribeiro, Marco Eigenfeld   +6 more
wiley   +1 more source

Renal toxicity of Bothrops moojeni snake venom and its main myotoxins

, 2015
Acute renal failure is one the most common systemic complications after snakebite, however, its pathogenesis remains obscure. In this study we evaluated the renal effects of Bothrops moojeni venom and its myotoxins (Bmtx-I and BmtxII) in rat isolated ...
Sousa, TM, Faco, PEG, Marangoni, S, Bezerra, ISAM, Fonteles, MC, Novello, JC, Monteiro, HSA, Havt, A, Barbosa, PSF, Toyama, MH   +9 more
core   +1 more source

Isolation and characterization of a myotoxin from the venom of Macrovipera lebetina transmediterranea

Toxicon, 2010
The Macrovipera lebetina venom consists of a complex mixture of proteins belonging to a few main families according to their enzymatic and pharmacological activity. Given the serious pathophysiological effects caused by M. lebetina bites mainly induced by muscle degeneration, we decided to investigate the myotoxic activity of some venom fractions.
Hamza, L, Girardi, T, Castelli, S, GARGIOLI, CESARE, CANNATA, STEFANO, Patamia, M, LULY, PAOLO, Laraba Djebari, F, Petruzzelli, R, RUFINI, STEFANO   +9 more
openaire   +5 more sources