Myotoxin-3 from the Pacific Rattlesnake Crotalus oreganus oreganus Venom Is a New Microtubule-Targeting Agent [PDF]
Molecules, 2022 Microtubule targeting agents (MTA) are anti-cancer molecules that bind tubulin and interfere with the microtubule functions, eventually leading to cell death.
María Cecilia González García +12 more
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Molecular Architecture of the Antiophidic Protein DM64 and its Binding Specificity to Myotoxin II From Bothrops asper Venom [PDF]
Frontiers in Molecular Biosciences, 2022 DM64 is a toxin-neutralizing serum glycoprotein isolated from Didelphis aurita, an ophiophagous marsupial naturally resistant to snake envenomation. This 64 kDa antitoxin targets myotoxic phospholipases A2, which account for most local tissue damage of ...
Barbara S. Soares +18 more
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Mouse Models of Muscle Fibrosis: Mechanisms, Methods, and Applications [PDF]
BiomedicinesSkeletal muscle injuries are common and some are able to regenerate due to satellite cells, the muscle stem cell population. However, in cases of severe muscle injury, complete tears, or muscle loss via trauma, muscles can undergo fibrosis and long-term ...
Sarah E. DiIorio +4 more
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Snakes on a plain: biotic and abiotic factors determine venom compositional variation in a wide-ranging generalist rattlesnake [PDF]
BMC Biology, 2023 Background Snake venoms are trophic adaptations that represent an ideal model to examine the evolutionary factors that shape polymorphic traits under strong natural selection.
Cara F. Smith +10 more
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Structure-based design of an antibacterial peptide from the Myotoxin II sequence, evaluating its effectiveness against Gram-negative bacteria and its safety [PDF]
Scientific ReportsBacterial resistance poses a significant public health challenge, particularly for pathogens prioritized by the World Health Organization, such as carbapenem-resistant Escherichia coli.
Tatiana Huertas +3 more
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Snake venom defensins: Defining the structural and functional characteristics of the toxin family [PDF]
Journal of Structural Biology: XSnake venom defensins are a toxin family found in rattlesnake venoms (Crotalus) which are comprised of crotamine-like peptides and myotoxins. Their tertiary structure resembles the β-defensin family structure.
David Melendez-Martinez +7 more
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Antibody-dependent enhancement of toxicity of myotoxin II from Bothrops asper [PDF]
Nature CommunicationsImproved therapies are needed against snakebite envenoming, which kills and permanently disables thousands of people each year. Recently developed neutralizing monoclonal antibodies against several snake toxins have shown promise in preclinical rodent ...
Christoffer V. Sørensen +16 more
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A plethora of rodents: Rattlesnake predators generate unanticipated patterns of venom resistance in a grassland ecosystem [PDF]
Toxicon: XPredation has the potential to impart strong selective pressures on organisms within their environments, resulting in adaptive changes in prey that minimize risk of predation.
Neil R. Balchan +2 more
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Revista Científica, 2022 A quantitative model to expose the adrenal gland sub-cellular alterations produced by crotamine-like (C-L) from rattlesnake venom during 3, 6 and 24 hours (h), and also qualitative changes on mice neuromuscular structures in vivo were observed and ...
Estefanie García +3 more
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Synergism between basic Asp49 and Lys49 phospholipase A2 myotoxins of viperid snake venom in vitro and in vivo. [PDF]
PLoS ONE, 2014 Two subtypes of phospholipases A2 (PLA2s) with the ability to induce myonecrosis, 'Asp49' and 'Lys49' myotoxins, often coexist in viperid snake venoms. Since the latter lack catalytic activity, two different mechanisms are involved in their myotoxicity ...
Diana Mora-Obando +4 more
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