Results 11 to 20 of about 2,019 (200)
Isolation and characterization of a myotoxin from Bothrops brazili Hoge, 1953 Hoge, 1953 snake venom (Ophidia: Viperidae). [PDF]
Revista Peruana de Biología, 2014 A myotoxin from the venom of the snake Bothrops brazili has been purified by ion-exchange chromatography on CM-Sephadex C-50 with 0,05 M ammonium acetate buffer pH 7.
Carmen Pantigoso +2 more
doaj +2 more sources
Antibody neutralization of a myotoxin from the venom of Bothrops asper (terciopelo)
Toxicon, 1987 Neutralization of biological activities of B. asper myotoxin by a monospecific anti-myotoxin rabbit serum and polyvalent antivenom was studied. Both antisera neutralized myotoxic, phospholipase A and lethal activities of myotoxin, whereas edema-forming activity of myotoxin was not neutralized by these antisera.
Lomonte, Bruno +3 more
openaire +5 more sources
Myotoxin a, Crotamine and Defensin Homologs in Reptile Venoms
, 2021 Snakebite envenomation is common in all inhabited continents of the world, with more than 100,000 fatalities occurring every year. Depending on the snake species involved, envenomation includes often disabling intense local tissue damage with inflammation, pain and myonecrosis, caused in part by molecules known as myotoxins.
Porta, Lucas C +3 more
openaire +2 more sources
Interaction of myotoxin a with the Ca2+-ATPase of skeletal muscle sarcoplasmic reticulum
Archives of Biochemistry and Biophysics, 1986 Myotoxin a is a muscle-damaging toxin isolated from the venom of Crotalus viridis viridis. Its interaction with the Ca2+-ATPase of sarcoplasmic reticulum (SR) vesicles purified from rabbit skeletal muscle was investigated. Myotoxin a inhibited Ca2+ loading and stimulated Ca2+-dependent ATPase without affecting unidirectional Ca2+ efflux. Its action was
P, Volpe, E, Damiani, A, Maurer, A T, Tu
openaire +3 more sources
, 2015 Myonecrosis is an important medical complication in snake envenoming and, in severe cases, can lead to drastic sequelae, such as inability and permanent tissue loss. Although the traditional serum therapy effectively neutralizes the systemic effects induced by snake venoms, there are some limitations in reversing the local symptoms induced by myotoxins,
Santos-Filho, Norival Alves +5 more
openaire +2 more sources
Individual expression patterns of myotoxin isoforms in the venom of the snake Bothrops asper
Comparative Biochemistry and Physiology Part B: Comparative Biochemistry, 1992 1. In order to investigate the distribution of myotoxin isoforms in the snake Bothrops asper, venoms from individual specimens were analyzed by a cathodic electrophoretic system for basic proteins under native conditions. 2. The electrophoretic system resolved at least five bands with slight differences in mobility, corresponding to the fastest ...
Carmona Morera, Elena, Lomonte, Bruno
openaire +5 more sources
Quantitative MRI Assessment of Myotoxin-Induced Skeletal Muscle Damage of mdx Mice. [PDF]
Muscle NerveABSTRACT Introduction/Aims Although magnetic resonance imaging (MRI) has been extensively applied in dystrophic muscle, longitudinal characterization of multiple quantitative MRI parameters during degeneration and regeneration remains limited. This study aimed to longitudinally characterize changes in quantitative MRI parameters in control and ...
Vohra R +4 more
europepmc +2 more sources
Animal Venoms as Peptide Libraries for the Discovery of Antiglioblastoma Agents. [PDF]
Biochem Res IntGlioblastoma is one of the most aggressive and widely recognized types of brain tumors, characterized by significant cellular and molecular diversity and an inherently aggressive nature. The treatment remains highly challenging, with limited effectiveness and persistently low survival rates.
Santiago LR +5 more
europepmc +2 more sources
SDS-induced hexameric oligomerization of myotoxin-II from Bothrops asper assessed by sedimentation velocity and nuclear magnetic resonance. [PDF]
Eur Biophys J, 2023 We report the solution behavior, oligomerization state, and structural details of myotoxin-II purified from the venom of Bothrops asper in the presence and absence of sodium dodecyl sulfate (SDS) and multiple lipids, as examined by analytical ...
Henrickson A +5 more
europepmc +2 more sources
Serum Proteinogram in the Free-Living Brazilian Common Opossum (Didelphis aurita). [PDF]
ElectrophoresisABSTRACT Didelphis aurita is a synanthropic marsupial widely distributed in southeastern Brazil, known for its resistance to venom and its relevance in biomedical research. This study aimed to characterize the serum proteinogram of free‐living D. aurita individuals.
Orozco AMO +9 more
europepmc +2 more sources