Journal of Cachexia, Sarcopenia and Muscle, 2021 Background Skeletal muscle regeneration is an adaptive response to injury that is crucial to the maintenance of muscle mass and function. A p21‐activated kinase 4 (PAK4) serine/threonine kinase is critical to the regulation of cytoskeletal changes, cell ...
Yuancheng Mao +5 more
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Endogenous phospholipase A2 inhibitors in snakes: a brief overview
Journal of Venomous Animals and Toxins including Tropical Diseases, 2017 The blood plasma of numerous snake species naturally comprises endogenous phospholipase A2 inhibitors, which primarily neutralize toxic phospholipases A2 that may eventually reach their circulation.
Patrícia Cota Campos +3 more
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Alpha-type phospholipase A2 inhibitors from snake blood
Journal of Venomous Animals and Toxins including Tropical Diseases, 2017 It is of popular and scientific knowledge that toxins from snake venom (among them the PLA2 and myotoxins) are neutralized by various compounds, such as antibodies and proteins purified from animal blood.
Norival A. Santos-Filho +1 more
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Crystallization of the Ca2+-ATPase of skeletal muscle sarcoplasmic reticulum. Inhibition by myotoxin a. [PDF]
, 1987 Decavanadate produces extensive ordered arrays of Ca2+-ATPase molecules on sarcoplasmic reticulum (SR) vesicle surfaces [(1984) J. Bioenerg. Biomembranes 16, 491-505] and the basic unit of these crystalline structures seems to be a dimer of Ca2+-ATPase [(
Andreas Maurer +5 more
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Heterologous expression of the antimyotoxic protein DM64 in Pichia pastoris.
PLoS Neglected Tropical Diseases, 2017 Snakebite envenomation is a neglected condition that constitutes a public health problem in tropical and subtropical countries, including Brazil.
Saulo Martins Vieira +4 more
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Recent Trends in Injury Models to Study Skeletal Muscle Regeneration and Repair
Bioengineering, 2020 Skeletal muscle injuries that occur from traumatic incidents, such as those caused by car accidents or surgical resections, or from injuries sustained on the battlefield, result in the loss of functionality of the injured muscle.
Sydnee T. Sicherer +2 more
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Pharmacological Properties of Vochysia Haenkeana (Vochysiaceae) Extract to Neutralize the Neuromuscular Blockade Induced by Bothropstoxin-I (Lys49 Phospholipase A2) Myotoxin [PDF]
Advanced Pharmaceutical Bulletin, 2017 Purpose: Bothrops snakes are responsible for more than 70 % of snakebites every year in Brazil and their venoms cause severe local and systemic damages. The pharmacological properties of medicinal plants have been widely investigated in order to discover
Carolina Harder +10 more
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Effects of Bothrops asper snake venom on lymphatic vessels: insights into a hidden aspect of envenomation. [PDF]
PLoS Neglected Tropical Diseases, 2008 Envenomations by the snake Bothrops asper represent a serious medical problem in Central America and parts of South America. These envenomations concur with drastic local tissue pathology, including a prominent edema. Since lymph flow plays a role in the
Javier Mora +3 more
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Corn Cultivation to Reduce the Mycotoxin Contamination
Research in Plant Disease, 2017 The effects of insecticide and fungicide treatment were investigated to reduce mycotoxin contamination of corn (Zea mays L.) seeds. Deoxynivalenol and zearalenone contents were reduced in the treated seeds, but aflatoxin, ochratoxin A, fumonisin, and T-2
Yangseon Kim +6 more
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POTENTIAL ANTIDOTE TO SNAKE VENOM MYOTOXIN [PDF]
Journal of Experimental Biology, 2012 ![][1] Snakebites are frequently hazardous accidents that require immediate medical treatment to neutralize the venom’s toxic effects. A feared complication of South American pit viper bites is extended myonecrosis, i.e.
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