Results 41 to 50 of about 2,019 (200)

Cytotoxic activity of a fixed amount of Lys49 myotoxin, alone or in combination with a low amount of Asp49 myotoxin.

, 2014
In this experiment, Asp49 myotoxin was first incubated for variable periods of time with C2C12 myotubes, and then washed five times, before the addition of Lys49 myotoxin. The indicated amounts of toxins were added in a total volume of 150 µL.
Bruno Lomonte (181809), Diana Mora-Obando (640895), Julián Fernández (5660767), José María Gutiérrez (62868), Cesare Montecucco (181820)   +4 more
core   +1 more source

Articular inflammation induced by an enzymatically-inactive Lys49 phospholipase A2: activation of endogenous phospholipases contributes to the pronociceptive effect

Journal of Venomous Animals and Toxins including Tropical Diseases, 2017
Background Arthritis is a set of inflammatory conditions that induce aching, stiffness, swelling, pain and may cause functional disability with severe consequences to the patient’s lives.
Renata Gonçalves Dias, Sandra Coccuzzo Sampaio, Morena Brazil Sant’Anna, Fernando Queiroz Cunha, José María Gutiérrez, Bruno Lomonte, Yara Cury, Gisele Picolo   +7 more
doaj   +1 more source

Computational Studies of Snake Venom Toxins

Toxins, 2017
Most snake venom toxins are proteins, and participate to envenomation through a diverse array of bioactivities, such as bleeding, inflammation, and pain, cytotoxic, cardiotoxic or neurotoxic effects.
Paola G. Ojeda, David Ramírez, Jans Alzate-Morales, Julio Caballero, Quentin Kaas, Wendy González   +5 more
doaj   +1 more source

Isolation and structural characterization of bioactive compound from Aristolochia sprucei aqueous extract with anti-myotoxic activity

Toxicon: X, 2020
A bioactive compound isolated from the stem extract of Aristolochia sprucei through High Performance Liquid Chromatography (HPLC) was identified via Nuclear Magnetic Resonance (NMR) as the aristolochic acid (AA). This compound showed an inhibitory effect
Isela I. González Rodríguez, Aleff F. Francisco, Leandro S. Moreira-Dill, Aristides Quintero, César L.S. Guimarães, Carlos A.H. Fernandes, Agnes A.S. Takeda, Fernando B. Zanchi, Cléopatra A.S. Caldeira, Paulo S. Pereira, Marcos R.M. Fontes, Juliana P. Zuliani, Andreimar M. Soares   +12 more
doaj   +1 more source

Inhibition of the Myotoxicity Induced by Bothrops jararacussu Venom and Isolated Phospholipases A2 by Specific Camelid Single-Domain Antibody Fragments. [PDF]

PLoS ONE, 2016
Antivenoms, produced using animal hyperimmune plasma, remains the standard therapy for snakebites. Although effective against systemic damages, conventional antivenoms have limited efficacy against local tissue damage.
Nidiane D R Prado, Soraya S Pereira, Michele P da Silva, Michelle S S Morais, Anderson M Kayano, Leandro S Moreira-Dill, Marcos B Luiz, Fernando B Zanchi, André L Fuly, Maribel E F Huacca, Cleberson F Fernandes, Leonardo A Calderon, Juliana P Zuliani, Luiz H Pereira da Silva, Andreimar M Soares, Rodrigo G Stabeli, Carla F C Fernandes   +16 more
doaj   +1 more source

Properties of specific binding site of myotoxin a, a powerful convulsant, in brain microsomes

, 1998
Myotoxin a, a small basic polypeptide from prairie rattlesnakes (Crotalus viridis viridis), induces myonecrosis and binds to a single class of binding sites in skeletal muscle sarcoplasmic reticulum.
Masamichi Ohkura, Osam Nakagawasai, Kensuke Kisara, Chikako Katagiri, Hiro-Hide Ishikawa, Yasushi Ohizumi, Takeshi Tadano   +6 more
core   +1 more source

Grafting of a single donor myofibre promotes hypertrophy in dystrophic mouse muscle.

PLoS ONE, 2013
Skeletal muscle has a remarkable capability of regeneration following injury. Satellite cells, the principal muscle stem cells, are responsible for this process.
Luisa Boldrin, Jennifer E Morgan
doaj   +1 more source

Phospholipase A2 myotoxins from Bothrops snake venoms

Toxicon, 1995
Several myotoxins have been isolated from Bothrops snake venoms during the last 10 years. All of them are group II basic phospholipases A2, although some lack enzymatic activity (i.e. Lys-49 variants). These myotoxins appear as an antigenically related family of proteins occurring in many, but not all, Bothrops venoms, bearing a close structural and ...
Gutiérrez, José María, Lomonte, Bruno
openaire   +3 more sources

Drug Discovery for Snakebite Envenoming: Wanderings Amid Historical Antidotes and Emerging Therapeutic Opportunities

ChemMedChem, Volume 21, Issue 21, 12 November 2026.
In this review, we provide an overview of selected historical antidotes against snakebite envenomation used in early modern Europe. Then, the evidence‐based antivenom activity of some natural compounds is discussed as resulting from more than two decades of research studies.
Elisa Bianconi, Emidio Camaioni, Paulina Oszajca, Antonio Macchiarulo   +3 more
wiley   +1 more source

Neutralization of the neuromuscular activity of bothropstoxin-i, a myotoxin from Bothrops jararacussu snake venom, by a hydroalcoholic extract of Casearia sylvestris Sw. (guaçatonga)

Journal of Venomous Animals and Toxins including Tropical Diseases, 2005
Numerous plants are used as snakebite antidotes in Brazilian folk medicine, including Casearia sylvestris Swartz, popularly known as guaçatonga. In this study, we examined the action of a hydroalcoholic extract from C.
Y. Oshima-Franco, C. M. V. Alves, N. Andréo Filho, M. Gerenutti, A. C. O. Cintra, G. B. Leite, L. Rodrigues-Simioni, M. G. Silva   +7 more
doaj   +1 more source