Results 61 to 70 of about 2,019 (200)

A Secreted Phospholipase A₂ Induces Formation of Smooth Muscle Foam Cells Which Transdifferentiate to Macrophage-Like State

Molecules, 2019
Vascular smooth muscle cells (VSMCs) loaded with lipid droplets (LDs) are markers of atherosclerosis. In this disease, inflammatory Group IIA-secreted phospholipase A2s (GIIA sPLA2s) are highly expressed in VSMCs, but their actions in these cells are ...
Karina Cristina Giannotti, Sönke Weinert, Mariana Nascimento Viana, Elbio Leiguez, Thaís L. S. Araujo, Francisco R. M. Laurindo, Bruno Lomonte, Rüdiger Braun-Dullaeus, Catarina Teixeira   +8 more
doaj   +1 more source

Effect of a recombinant Lys49PLA2 myotoxin and Lys49PLA2-derived synthetic peptides from Agkistrodon species on membrane permeability to water

, 2004
The aim of this work was to study the effect of recombinant ACL myotoxin, a Lys49PLA2 from Agkistrodon contortrix laticinctus snake venom and Lys49PLA2-derived synthetic peptides corresponding to the region 115–129 of venom of the two different ...
Giuliani, C. D., Lomonte, Bruno, Franco, Wilfredo, Leite, R. S., Selistre de Araujo, Heloisa S.   +4 more
core   +1 more source

Table1_Molecular Architecture of the Antiophidic Protein DM64 and its Binding Specificity to Myotoxin II From Bothrops asper Venom.XLSX

, 2022
DM64 is a toxin-neutralizing serum glycoprotein isolated from Didelphis aurita, an ophiophagous marsupial naturally resistant to snake envenomation. This 64 kDa antitoxin targets myotoxic phospholipases A2, which account for most local tissue damage of ...
Thomas J. D. Jørgensen (8862011), Bruno Lomonte (181809), Borries Demeler (431852), Barbara S. Soares (12008543), Viviane A. Bastos (12008549), Ana Gisele C. Neves-Ferreira (5916077), Tayler L. Williams (5118065), Amy Henrickson (8997298), Jonas Perales (158987), Janelle Arnold (12008552), Francisco Gomes-Neto (1615534), Richard H. Valente (158989), Diogo B. Lima (1903639), Tatiana A. C. B. Souza (12008555), Surza Lucia G. Rocha (12008546), Paulo C. Carvalho (1590364), Fabio C. Gozzo (104392)   +16 more
core   +1 more source

Geographic variation in the clinical features of Mohave rattlesnake (Crotalus scutulatus) envenomations reported to the North American Snakebite Registry

Toxicon: X
The geographic variation of Mohave rattlesnake (Crotalus scutulatus) venom is well established. We reviewed all the Mohave rattlesnake bites reported to the Toxicology Investigators Consortium's North American Snakebite Registry between January 1, 2015 ...
Spencer Greene, Matthew Gilbert, Brian Wolk, Sharan Campleman, Anne-Michelle Ruha   +4 more
doaj   +1 more source

Unveiling the Leishmanicidal Mechanism of 4‐Nerolidylcatechol Isolated From Piper peltatum Against Leishmania infantum

Chemistry &Biodiversity, Volume 23, Issue 1, January 2026.
ABSTRACT The present study assessed the leishmanicidal activity of 4‐nerolidylcatechol (4‐NC) (1) isolated from Piper peltatum leaves against promastigotes and amastigotes of Leishmania amazonensis, L. braziliensis, and L. infantum. The plant was fractionated, leading to the isolation and chemical identification of 4‐NC (1). Biochemical techniques were
Fabiana Brusco Lorenzetti, Rodolfo Bento Balbinot, Danielle Lazarin‐Bidóia, Viviane dos Santos Faiões, Eduardo Caio Torres‐Santos, Celso Vataru Nakamura, Tânia Ueda‐Nakamura, Diógenes Aparício Garcia Cortez, Benedito Prado Dias Filho   +8 more
wiley   +1 more source

Image10_Molecular Architecture of the Antiophidic Protein DM64 and its Binding Specificity to Myotoxin II From Bothrops asper Venom.JPEG

, 2022
DM64 is a toxin-neutralizing serum glycoprotein isolated from Didelphis aurita, an ophiophagous marsupial naturally resistant to snake envenomation. This 64 kDa antitoxin targets myotoxic phospholipases A2, which account for most local tissue damage of ...
Thomas J. D. Jørgensen (8862011), Bruno Lomonte (181809), Borries Demeler (431852), Barbara S. Soares (12008543), Viviane A. Bastos (12008549), Ana Gisele C. Neves-Ferreira (5916077), Tayler L. Williams (5118065), Amy Henrickson (8997298), Jonas Perales (158987), Janelle Arnold (12008552), Francisco Gomes-Neto (1615534), Richard H. Valente (158989), Diogo B. Lima (1903639), Tatiana A. C. B. Souza (12008555), Surza Lucia G. Rocha (12008546), Paulo C. Carvalho (1590364), Fabio C. Gozzo (104392)   +16 more
core   +1 more source

Transcriptomic Insights Into the Evolution of Snake Venom: Mechanisms, Diversity, and Adaptation

Scientifica, Volume 2026, Issue 1, 2026.
Snake venoms are evolutionarily refined biochemical arsenals composed of diverse toxins with complex functional roles in predation, defense, and competition. Over the past 2 decades, transcriptomic approaches have transformed venom research by enabling high‐resolution insights into gene expression dynamics, molecular diversity, and the evolutionary ...
Fajar Sofyantoro, Wisnu Ananta Kusuma, Setyanto Tri Wahyudi, Favorisen Rosyking Lumbanraja, Hendra Rahmawan, Heru Cahya Rustamaji, Dhadhang Wahyu Kurniawan, Undri Rastuti, Wahyu Aristyaning Putri, Wiko Arif Wibowo, Dwi Sendi Priyono, Donan Satria Yudha, Slamet Raharjo, Tri Rini Nuringtyas, Nidhi Chaudhary   +14 more
wiley   +1 more source

Effects of Bothrops asper (terciopelo) myotoxin III, a basic phospholipase A2, on liposomes and mouse gastrocnemius muscle

, 1993
The action of Bothrops asper myotoxin III, a basic phospholipase A2 which induces acute muscle damage, was studied in mouse gastrocnemius muscle in vivo and in vitro and in multilamellar liposomes.
Thelestam, Mónica, Bultrón, Euris, Gutiérrez, José María   +2 more
core   +1 more source

Image3_Molecular Architecture of the Antiophidic Protein DM64 and its Binding Specificity to Myotoxin II From Bothrops asper Venom.JPEG

, 2022
DM64 is a toxin-neutralizing serum glycoprotein isolated from Didelphis aurita, an ophiophagous marsupial naturally resistant to snake envenomation. This 64 kDa antitoxin targets myotoxic phospholipases A2, which account for most local tissue damage of ...
Thomas J. D. Jørgensen (8862011), Bruno Lomonte (181809), Borries Demeler (431852), Barbara S. Soares (12008543), Viviane A. Bastos (12008549), Ana Gisele C. Neves-Ferreira (5916077), Tayler L. Williams (5118065), Amy Henrickson (8997298), Jonas Perales (158987), Janelle Arnold (12008552), Francisco Gomes-Neto (1615534), Richard H. Valente (158989), Diogo B. Lima (1903639), Tatiana A. C. B. Souza (12008555), Surza Lucia G. Rocha (12008546), Paulo C. Carvalho (1590364), Fabio C. Gozzo (104392)   +16 more
core   +1 more source

Bactericidal activity of Lys49 and Asp49 myotoxic phospholipases A2 from Bothrops asper snake venom--synthetic Lys49 myotoxin II-(115-129)-peptide identifies its bactericidal region

, 1998
Mammalian group-II phospholipases A2 (PLA2) of inflammatory fluids display bactericidal properties, which are dependent on their enzymatic activity. This study shows that myotoxins II (Lys49) and III (Asp49), two group-II PLA2 isoforms from the venom of ...
Moreno, E, Pizarro-Cerdá, J, Bengoechea, J A; id_orcid, Gorvel, J P, Lomonte, B, Páramo, L   +5 more
core   +3 more sources