Results 71 to 80 of about 2,019 (200)

Structural and functional studies of a bothropic myotoxin complexed to rosmarinic acid: new insights into Lys49-PLA₂ inhibition.

PLoS ONE, 2011
Snakebite envenoming is an important public health problem in many tropical and subtropical countries, and is considered a neglected tropical disease by the World Health Organization.
Juliana I Dos Santos, Fábio F Cardoso, Andreimar M Soares, Maeli Dal Pai Silva, Márcia Gallacci, Marcos R M Fontes   +5 more
doaj   +1 more source

Antitumor potential of the myotoxin BthTX-I from Bothrops jararacussu snake venom: evaluation of cell cycle alterations and death mechanisms induced in tumor cell lines

Journal of Venomous Animals and Toxins including Tropical Diseases, 2015
Background Phospholipases A 2 (PLA 2 s) are abundant components of snake venoms that have been extensively studied due to their pharmacological and pathophysiological effects on living organisms.
Cássio Prinholato da Silva, Tássia R. Costa, Raquel M. Alves Paiva, Adélia C. O. Cintra, Danilo L. Menaldo, Lusânia M. Greggi Antunes, Suely V. Sampaio   +6 more
doaj   +1 more source

Spatially Resolved Profiling of Compartmentalized Muscle and Brain Inflammation

European Journal of Immunology, Volume 55, Issue 12, December 2025.
This review summarizes emerging spatially resolved multi‐omics approaches revealing organized cell–cell interactions in skeletal muscle and brain inflammation. These tools uncover radiating molecular programs and niche‐specific immunopathology that shape cellular reactivity and vulnerability.
Thorge Dobbertin, Lucas Schirmer
wiley   +1 more source

Image11_Molecular Architecture of the Antiophidic Protein DM64 and its Binding Specificity to Myotoxin II From Bothrops asper Venom.JPEG

, 2022
DM64 is a toxin-neutralizing serum glycoprotein isolated from Didelphis aurita, an ophiophagous marsupial naturally resistant to snake envenomation. This 64 kDa antitoxin targets myotoxic phospholipases A2, which account for most local tissue damage of ...
Thomas J. D. Jørgensen (8862011), Bruno Lomonte (181809), Borries Demeler (431852), Barbara S. Soares (12008543), Viviane A. Bastos (12008549), Ana Gisele C. Neves-Ferreira (5916077), Tayler L. Williams (5118065), Amy Henrickson (8997298), Jonas Perales (158987), Janelle Arnold (12008552), Francisco Gomes-Neto (1615534), Richard H. Valente (158989), Diogo B. Lima (1903639), Tatiana A. C. B. Souza (12008555), Surza Lucia G. Rocha (12008546), Paulo C. Carvalho (1590364), Fabio C. Gozzo (104392)   +16 more
core   +1 more source

Isolation and characterization of a myotoxin from the venom of Macrovipera lebetina transmediterranea

Toxicon, 2010
The Macrovipera lebetina venom consists of a complex mixture of proteins belonging to a few main families according to their enzymatic and pharmacological activity. Given the serious pathophysiological effects caused by M. lebetina bites mainly induced by muscle degeneration, we decided to investigate the myotoxic activity of some venom fractions.
Hamza, L, Girardi, T, Castelli, S, GARGIOLI, CESARE, CANNATA, STEFANO, Patamia, M, LULY, PAOLO, Laraba Djebari, F, Petruzzelli, R, RUFINI, STEFANO   +9 more
openaire   +5 more sources

The Effect of Anti‐3‐Hydroxy‐3‐Methylglutaryl‐CoA Reductase (HMGCR) Human Autoantibodies on Muscle Regeneration in Mice

Muscle &Nerve, Volume 72, Issue 6, Page 1300-1308, December 2025.
ABSTRACT Introduction/Aims Anti‐3‐hydroxy‐3‐methylglutaryl‐CoA reductase (HMGCR) autoantibodies (aAbs) are pathogenic in immune‐mediated necrotizing myopathy (IMNM), partly through complement activation. C5 inhibition did not restore muscle strength in mice or patients with overt IMNM, suggesting additional pathogenic mechanisms.
Sarah Julien, Honorine Tomasevic, Thara Jaworski, Rachid Zoubairi, Jeremie Martinet, Laurent Drouot, Olivier Boyer   +6 more
wiley   +1 more source

Broad cytolytic specificity of myotoxin II, a lysine-49 phospholipase A2 of Bothrops asper snake venom

, 1994
The cytotoxic activity of Bothrops asper myotoxin II, a lysine-49 phospholipase A2 isoform, on different cell types in culture, was investigated. Myotoxin II caused a dose-dependent cytolytic effect on all cell types tested, characterized by rapid ...
Tarkowski, Andrej, Lomonte, Bruno, Hanson, Lars Ake   +2 more
core   +1 more source

Image2_Molecular Architecture of the Antiophidic Protein DM64 and its Binding Specificity to Myotoxin II From Bothrops asper Venom.TIF

, 2022
DM64 is a toxin-neutralizing serum glycoprotein isolated from Didelphis aurita, an ophiophagous marsupial naturally resistant to snake envenomation. This 64 kDa antitoxin targets myotoxic phospholipases A2, which account for most local tissue damage of ...
Thomas J. D. Jørgensen (8862011), Bruno Lomonte (181809), Borries Demeler (431852), Barbara S. Soares (12008543), Viviane A. Bastos (12008549), Ana Gisele C. Neves-Ferreira (5916077), Tayler L. Williams (5118065), Amy Henrickson (8997298), Jonas Perales (158987), Janelle Arnold (12008552), Francisco Gomes-Neto (1615534), Richard H. Valente (158989), Diogo B. Lima (1903639), Tatiana A. C. B. Souza (12008555), Surza Lucia G. Rocha (12008546), Paulo C. Carvalho (1590364), Fabio C. Gozzo (104392)   +16 more
core   +1 more source

Predation Strategies of the Portuguese Man‐of‐War Physalia physalis

Marine Ecology, Volume 46, Issue 6, November/December 2025.
ABSTRACT The Portuguese man‐of‐war Physalia physalis is widely known for causing poisoning on human beings. Physalia physalis is mostly described as a predator of fish eggs and larvae. Here, we report for the first time that large fish can also be preyed by P. physalis.
Jorge L. S. Nunes, Diego S. Campos, Héllida Negrão Dias, Luiz P. N. e Silva, Denise M. R. F. Bastos, Tommaso Giarrizzo, Allan Jamesson Silva de Jesus, Jamerson Aguiar‐Santos, Ana Catarina Miranda   +8 more
wiley   +1 more source

Characterization of a myotoxin from the Duvernoy's gland secretion of the xenodontine colubrid Philodryas olfersii (green snake): Effects on striated muscle and the neuromuscular junction

, 1998
A myotoxin has been isolated from the Duvernoy's gland (DG) secretion of the xenodontine colubrid Philodryas olfersii (green snake) by gel filtration on Sephadex G-100 SF. Under non-reducing and reducing conditions in SDS-PAGE, the myotoxin migrates as a
Andrade, AL, Prado-Franceschi, J, Hyslop, S, Cogo, JC, Rodrigues-Simioni, L, Assakura, MT, Reichl, AP, Cruz-Hofling, MA, M.T. Assakura, J.C. Cogo, A.L. Andrade, M.A. Cruz-Höfling, L. Rodrigues-Simioni, A.P. Reichl, S. Hyslop, J. Prado-Franceschi   +15 more
core   +1 more source