Results 81 to 90 of about 975 (184)

Why myotoxin-containing snake venoms possess powerful nucleotidases?

, 2013
The venom of the snake Bothrops asper causes muscle necrosis, pain and inflammation. This venom contains myotoxins which cause an increase in intracellular Ca(2+) concentration and release of K(+) and ATP from myotubes.
José María Gutiérrez, Bruno Lomonte, PELLEGATTI, Patrizia, Fernandez J, MONTECUCCO, CESARE, Cintra Francischinelli, Mariana, Gutiérrez JM, Patrizia Pellegatti, Caccin P, Julián Fernandez, Francesco Di Virgilio, Cintra Francischinelli M, DI VIRGILIO, Francesco, Lomonte B, Fernández Ulate, Julián, VONO, MARIA, Montecucco C., CACCIN, PAOLA, Vono M, Lomonte, Bruno, Gutiérrez, José María, Mariana Cintra Francischinelli, Montecucco C, Di Virgilio F, CintraFrancischinelli M, Pellegatti P   +25 more
core   +1 more source

Ability of fucoidan to prevent muscle necrosis induced by snake venom myotoxins: comparison of high- and low-molecular weight fractions

, 2008
Fucoidan, a natural polysaccharide extracted from brown seaweed, inhibits the myotoxic phospholipases A2 present in the venoms of crotalid snakes. This study evaluated the influence of molecular weight on the ability of fucoidan to prevent muscle ...
Angulo Ugalde, Yamileth, Lomonte, Bruno, Azofeifa Chinchilla, Karol   +2 more
core   +1 more source

Identification and Characterization of Voltage-Gated Potassium Channels as the Cell Surface Target that Mediates the Anti-Proliferative Activity of Snake Venom Myotoxins [PDF]

, 2019
Background: Myotoxins are a family of small protein toxins present in the venom of multiple species of pit vipers that have selective toxic effects on different types of tissues.
Yin, Chunhui
core  

03 02 a RE Lomonte-03-05-11.qxp

, 2020
PLA 2 s constitute a large superfamily of enzymes which are widely distributed in living organisms. On the basis of their structural and biochemical properties, these enzymes have been classified within at least 15 groups Abstract Phospholipases A 2 ...
Bruno Lomonte, José María Gutiérrez, Slogar   +2 more
core  

An overview of Lysine-49 phospholipase A2 myotoxins from crotalid snake venoms and their structural determinants of myotoxic action

, 2003
In 1984, the first venom phospholipase A2 (PLA2) with a lysine substituting for the highly conserved aspartate 49 was discovered, in the North American crotalid snake Agkistrodon p. piscivorus [J. Biol. Chem. 259 (1984) 13839].
Angulo Ugalde, Yamileth, Lomonte, Bruno, Calderón Fuentes, Leonel   +2 more
core   +1 more source

In Vitro Efficacy of Antivenom and Varespladib in Neutralising Chinese Russell's Viper (Daboia siamensis) Venom Toxicity. [PDF]

Toxins (Basel), 2023
Lay M, Liang Q, Isbister GK, Hodgson WC.
europepmc   +1 more source

Phospholipase A(2) myotoxins from Bothrops snake venoms: Structure-function relationship

, 2004
Phospholipases A(2) constitute the major components from Bothrops snake venoms and have been extensively investigated not only because they are relatively very abundant in these venoms but mainly because they display a range of many relevant biological ...
Fontes, MRM, Soares, A. M., Giglio, JR
core   +1 more source

Antibody-dependent enhancement of toxicity of myotoxin II from Bothrops asper

Nature Communications
AbstractImproved therapies are needed against snakebite envenoming, which kills and permanently disables thousands of people each year. Recently developed neutralizing monoclonal antibodies against several snake toxins have shown promise in preclinical rodent models. Here, we use phage display technology to discover a human monoclonal antibody and show 
Christoffer V. Sørensen, Julián Fernández, Anna Christina Adams, Helen H. K. Wildenauer, Sanne Schoffelen, Line Ledsgaard, Manuela B. Pucca, Michael Fiebig, Felipe A. Cerni, Tulika Tulika, Bjørn G. Voldborg, Aneesh Karatt-Vellatt, J. Preben Morth, Anne Ljungars, Lise M. Grav, Bruno Lomonte, Andreas H. Laustsen   +16 more
openaire   +4 more sources

ANTI-INFLAMMATORY ACTIVITY OF Blutaparon portulacoides ETHANOLIC EXTRACT AGAINST THE INFLAMMATORY REACTION INDUCED BY Bothrops jararacussu VENOM AND ISOLATED MYOTOXINS BthTX-I AND II

, 2015
This article reports the anti-inflammatory effect of Blutaparon portulacoides (B. portulacoides), specifically the ethanolic extract of its aerial parts, on the edema formation and leukocyte influx caused by Bothrops jararacussu (B.
Ribeiro, W, Salvador, MJ, Zamuner, SR, Cogo, JC, Barbosa, AM, Pereira, IC, Soares, AM   +6 more
core  

In Vitro Neutralization of the Myotoxicity of Australian Mulga Snake (Pseudechis australis) and Sri Lankan Russell's Viper (Daboia russelii) Venoms by Australian and Indian Polyvalent Antivenoms. [PDF]

Toxins (Basel), 2022
Thakshila P, Hodgson WC, Isbister GK, Silva A.   +3 more
europepmc   +1 more source