Results 11 to 20 of about 975 (184)

Low-level laser therapy decreases local effects induced by myotoxins isolated from Bothrops jararacussu snake venom [PDF]

Journal of Venomous Animals and Toxins including Tropical Diseases, 2010
The prominent myotoxic effects induced by Bothrops jararacussu crude venom are due, in part, to its polycationic myotoxins, BthTX-I and BthTX-II. Both myotoxins have a phospholipase A2 structure: BthTX-II is an active enzyme Asp-49 PLA2, while BthTX-I is
AM Barbosa, AB Villaverde, L Guimarães-Sousa, AM Soares, SF Zamuner, JC Cogo, SR Zamuner   +6 more
doaj   +2 more sources

Autocatalytic Acylation of Phospholipase-like Myotoxins

Biochemistry, 1995
Several snake venoms contain a phospholipase A2 in which position 49 in the active site is occupied by a lysine or a serine instead of the aspartate residue normally found. Although these proteins do not bind Ca2+ and are devoid of catalytic activity, they are still highly specific myotoxins and have recently been shown to induce membrane leakage by a ...
PEDERSEN, JENS ZACHO, Lomonte, B, MASSOUD, RENATO, Gubensek, F, Gutiérrez, J, RUFINI, STEFANO   +5 more
openaire   +6 more sources

Neutralization of pharmacological and toxic activities of Bothrops jararacussu snake venom and isolated myotoxins by Serjania erecta methanolic extract and its fractions [PDF]

Journal of Venomous Animals and Toxins including Tropical Diseases, 2011
Most of the snakebites recorded in Brazil are caused by the Bothrops genus. Given that the local tissue damage caused by this genus cannot be treated by antivenom therapy, numerous studies are focusing on supplementary alternatives, such as the use of ...
RS Fernandes, TR Costa, S Marcussi, CP Bernardes, DL Menaldo, II Rodriguéz Gonzaléz, PS Pereira, AM Soares   +7 more
doaj   +4 more sources

Anti-inflammatory activity of Blutaparon portulacoides ethanolic extract against the inflammatory reaction induced by Bothrops jararacussu venom and isolated myotoxins BthTX-I and II

Journal of Venomous Animals and Toxins including Tropical Diseases, 2009
This article reports the anti-inflammatory effect of Blutaparon portulacoides (B. portulacoides), specifically the ethanolic extract of its aerial parts, on the edema formation and leukocyte influx caused by Bothrops jararacussu (B.
IC Pereira, AM Barbosa, MJ Salvador, AM Soares, W Ribeiro, JC Cogo, SR Zamuner   +6 more
doaj   +2 more sources

Myotoxin Inhibitors

, 2015
Myonecrosis is an important medical complication in snake envenoming and, in severe cases, can lead to drastic sequelae, such as inability and permanent tissue loss. Although the traditional serum therapy effectively neutralizes the systemic effects induced by snake venoms, there are some limitations in reversing the local symptoms induced by myotoxins,
Santos-Filho, Norival Alves, Silveira, Lucas Blundi, Boldrini-Franca, Johara, Cruz, L. J., Luo, S., Gopalakrishnakone, P.   +5 more
openaire   +2 more sources

Alpha-type phospholipase A2 inhibitors from snake blood [PDF]

Journal of Venomous Animals and Toxins including Tropical Diseases, 2017
It is of popular and scientific knowledge that toxins from snake venom (among them the PLA2 and myotoxins) are neutralized by various compounds, such as antibodies and proteins purified from animal blood.
Norival A. Santos-Filho, Claudia T. Santos   +1 more
doaj   +2 more sources

Skeletal muscle fiber hypercontraction induced by Bothrops asper myotoxic phospholipases A₂ ex vivo does not involve a direct action on the contractile apparatus. [PDF]

Pflugers Arch, 2023
Myonecrosis is a frequent clinical manifestation of envenomings by Viperidae snakes, mainly caused by the toxic actions of secreted phospholipase A2 ( sPLA2) enzymes and sPLA2- like homologs on skeletal muscle fibers.
López-Dávila AJ, Weber N, Nayak A, Fritz L, Moustafa KR, Gand LV, Wehry E, Kraft T, Thum T, Fernández J, Gutiérrez JM, Lomonte B.   +11 more
europepmc   +2 more sources

The many dimeric faces of Lys49 PLA₂-like proteins: Conformational plasticity and membrane binding drive functional dimer states. [PDF]

Protein Sci
Abstract Lys49 secreted phospholipase A2‐like proteins (sPLA2s) are major myotoxins in viperid snake venoms, causing rapid muscle damage in envenomation. Beyond their clinical relevance, these small non‐catalytic proteins provide a model to study how quaternary structure and conformational dynamics enable catalysis‐independent membrane disruption ...
Lima DCA, Dos Santos VF, Rassi B, Ward RJ, Soares TA.   +4 more
europepmc   +2 more sources

Effect of Fungal Toxins on Immunodefic Indicators

مجلة مركز بحوث التقنيات الاحيائية, 2022
   Mycotoxins are natural toxins generally caused by some types of mold (fungi) that may be found in foods. Mold (Fungi) grows on (grains, nuts, spices, dried fruits, apples, and coffee seeds).
Semaa A. Shaban , Milad A. Mezher, Rafea Alsugmainy   +2 more
doaj   +1 more source

Mechanism of inhibition of Ca2+-ATPase by myotoxin a [PDF]

Biochemical Journal, 1995
The peptide DCRQKWKCCKKGSG [myotoxin-(29-42)], corresponding to residues 29-42 of myotoxin a, inhibits the activity of the Ca(2+)-ATPase of skeletal muscle sarcoplasmic reticulum, with a Kd value of 19.4 microM at pH 7.5, in 100 mM KCl. The peptide YKQCHKKGGHCFPKEK, corresponding to residues 1-16 of myotoxin a, is a less potent inhibitor. Inhibition by
K J, Baker, J M, East, A G, Lee
openaire   +2 more sources