Results 161 to 170 of about 2,993 (188)

PTEN and Myotubularin Phosphatases: From 3-Phosphoinositide Dephosphorylation to Disease

Trends in Cell Biology, 2002
The phosphatase and tensin homolog deleted on chromosome ten (PTEN) and myotubularin (MTM1) represent subfamilies of protein tyrosine phosphatases whose principal physiological substrates are D3-phosphorylated inositol phospholipids. As lipid phosphatases, PTEN- and MTM1-related (MTMR) proteins dephosphorylate the products of phosphoinositide 3-kinases
Jack E. Dixon
exaly   +3 more sources

I-proteins – a proposed switch in myotubularin function

Trends in Biochemical Sciences, 2004
In this article, we consider the functions of the myotubularins - a large family of phosphoinositide 3-phosphatases. By analogy with the phosphatidylinositol 3-phosphatase PTEN (phosphatase and tensin homolog deleted in chromosome ten) and many protein phosphatases, it has been proposed that the primary function of this protein family is to regulate ...
Clague, M., Dove, S., Barr, F.
openaire   +3 more sources

Multiple disease‐linked myotubularin mutations cause NFL assembly defects in cultured cells and disrupt myotubularin dimerization

Journal of Neurochemistry, 2007
J. Neurochem.(2008) 104, 1536–1552.AbstractCharcot‐Marie‐Tooth disease (CMT) is an inherited peripheral neuropathy that has been linked to mutations in multiple genes. Mutations in the neurofilament light (NFL) chain gene lead to the CMT2E form whereas mutations in the myotubularin‐related protein 2 and 13 (MTMR2 and MTMR13) genes lead to the CMT4B ...
Dmitry, Goryunov, Andrew, Nightingale, Lorelei, Bornfleth, Conrad, Leung, Ronald K H, Liem   +4 more
openaire   +2 more sources

PTEN and Myotubularin Phosphoinositide Phosphatases: Bringing Bioinformatics to the Lab Bench

Current Opinion in Cell Biology, 2001
Phosphoinositides play an integral role in a diverse array of cellular signaling processes. Although considerable effort has been directed toward characterizing the kinases that produce inositol lipid second messengers, the study of phosphatases that oppose these kinases remains limited.
James T Slama, Jack E. Dixon, Gregory S Taylor   +2 more
exaly   +3 more sources

Myotubularin-related phosphatase 5 is a critical determinant of autophagy in neurons

Current Biology, 2022
Autophagy is a conserved, multi-step process of capturing proteolytic cargo in autophagosomes for lysosome degradation. The capacity to remove toxic proteins that accumulate in neurodegenerative disorders attests to the disease-modifying potential of the autophagy pathway.
Jason P. Chua, Karan Bedi, Michelle T. Paulsen, Mats Ljungman, Elizabeth M.H. Tank, Erin S. Kim, Jonathon P. McBride, Jennifer M. Colón-Mercado, Michael E. Ward, Lois S. Weisman, Sami J. Barmada   +10 more
openaire   +2 more sources

Expression, Purification, Crystallization and Preliminary Crystallographic Analysis of Human Myotubularin-Related Protein 3

Acta Crystallographica Section F, Structural Biology Communications, 2014
Myotubularin-related proteins are a large family of phosphatases that have the catalytic activity of dephosphorylating the phospholipid molecules phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate.
Jee Un Lee, Seung Jun Kim, Yong-Seok Heo
exaly   +2 more sources

Myotubularin Phosphoinositide Phosphatases in Human Diseases

2012
The level and turnover of phosphoinositides (PIs) are tightly controlled by a large set of PI-specific enzymes (PI kinases and phosphatases). Mammalian PI phosphatases are conserved through evolution and among this large family the dual-specificity phosphatase (PTP/DSP) are metal-independent enzymes displaying the amino acid signature Cys-X5-Arg-Thr ...
Amoasii, Leonela, Hnia, Karim, Laporte, Jocelyn   +2 more
openaire   +2 more sources

PTEN and Myotubularins: Families of Phosphoinositide Phosphatases

2003
Publisher Summary This chapter discusses PTEN and Mytobularins, families of Phosphoinositides phosphatases, playing crucial roles in a variety of complex cellular processes. The involvement of phosphoinositides in such a striking number of physiologic processes has led to intensive study of the protein effectors, including lipid kinases and ...
Gregory S, Taylor, Jack E, Dixon
openaire   +2 more sources

Myotubularin phosphoinositide phosphatases: cellular functions and disease pathophysiology

Trends in Molecular Medicine, 2012
The myotubularin family of phosphoinositide phosphatases includes several members mutated in neuromuscular diseases or associated with metabolic syndrome, obesity, and cancer. Catalytically dead phosphatases regulate their active homologs by heterodimerization and potentially represent key players in the phosphatase-kinase balance.
Hnia, Karim, Vaccari, Ilaria, Bolino, Alessandra, Laporte, Jocelyn   +3 more
openaire   +3 more sources

A Novel Homozygous Missense Mutation in the Myotubularin-Related Protein 2 Gene Associated With Recessive Charcot–Marie–Tooth Disease With Irregularly Folded Myelin Sheaths

Neuromuscular Disorders, 2002
Mutations in the myotubularin-related protein 2 gene on chromosome 11q22 are known to cause autosomal recessive Charcot-Marie-Tooth disease with irregularly folded myelin sheaths.
Vincent Timmerman, Haluk Topaloğlu, Christine Van Broeckhoven   +2 more
exaly   +2 more sources