Results 101 to 110 of about 593,619 (307)

“Irrevocable Words,” or Why Maria Kirilovna “Deceived” Dubrovsky

open access: yesНаучный диалог, 2018
The features of the plot behaviour of Maria Kirilovna Troekurova, the main character of the novel “Dubrovsky,” are discusses. The relevance of the study is due to the lack of works explaining one of the main mysteries of Pushkin’s text - the discrepancy ...
S. A. Larin
doaj   +1 more source

Distinct Effects of Complement C4A and C4B Copy Numbers in Systemic Sclerosis Serological and Clinical Subtypes

open access: yesArthritis &Rheumatology, EarlyView.
Objective Complement component 4 (C4), encoded by C4A and C4B within the major histocompatibility complex (MHC) on chromosome 6, regulates the immune response and clears immune complexes. The variable copy number (CN) of C4 genes and retroviral human endogenous retrovirus K (HERV‐K) element influence its function.
Javier Martínez‐López   +156 more
wiley   +1 more source

Multi‐omic profiling reveals immune cell priming signature linked to lupus prognosis

open access: yesArthritis &Rheumatology, Accepted Article.
Objective Systemic lupus erythematosus (SLE) is a multi‐organ disease with widespread immune dysregulation and significant unmet clinical need. Blood‐based gene expression studies have advanced our understanding of SLE pathogenesis but may overlook critical tissue‐specific mechanisms that drive disease heterogeneity and progression.
Michael A. Smith   +23 more
wiley   +1 more source

Single‐cell level characterization of B cell depletion and repopulation following rituximab in systemic lupus erythematosus

open access: yesArthritis &Rheumatology, Accepted Article.
Objective Rituximab, a CD20+ B cell depletion therapy, is frequently used to treat systemic lupus erythematosus (SLE). However, variability in patient response highlights the need for a deeper understanding of the underlying immune cell dynamics of B cell depletion and repopulation.
Haerin Jang   +9 more
wiley   +1 more source

Association of Clonal Hematopoiesis with Incident, Late‐Onset, Seropositive Rheumatoid Arthritis

open access: yesArthritis &Rheumatology, Accepted Article.
Objectives Clonal hematopoiesis (CH), defined by acquired driver mutations in hematopoietic stem cells, is associated with many inflammatory diseases of aging. We investigated whether CH and its subtypes, clonal hematopoiesis of indeterminate potential (CHIP) and mosaic chromosomal alteration (mCA), are associated with incident rheumatoid arthritis (RA)
Kun Zhao   +8 more
wiley   +1 more source

Mystery Shopping: In-depth measurement of customer satisfaction [PDF]

open access: yes
This paper will discuss the phenomenon Mystery Shopping in the fieldof customer satisfaction measurement techniques. By using theliterature about Mystery Shopping definitions and restrictions of thisinstrument will be presented.
Hesselink, M., Wiele, A. van der
core   +1 more source

Beyond Kahoot! Reflections and guidelines from a serial gamifying educator on when and how to effectively use games and game elements in anatomical education

open access: yesAnatomical Sciences Education, EarlyView.
Abstract According to Nietzsche, “In every real [adult], a child is hidden that wants to play.” In everyday life, playfulness and competition can make routine or dull tasks more engaging and can offer educators opportunities to engage a learner in a more entertaining or interactive manner.
Judi Laprade
wiley   +1 more source

THE COGNITIV MODEL BLAGA – POPPER [PDF]

open access: yesStudiul Artelor şi Culturologie: Istorie, Teorie, Practică, 2019
In the proposed research there is a comparative analysis of two conceptions – of the English thinker Karl R. Popper (1902-1994) and of the Romanian thinker Lucian Blaga (1895 – 1961), thinkers who launched the idea of a new model of knowledge and that ...
NEGRU NICOLAE
doaj  

THE MYSTERY OF MONOGAMY [PDF]

open access: yes
This paper examines why developed countries are monogamous while rich men throughout history have tended to practice polygyny (multiple wives). Wealth inequality naturally produces multiple wives for rich men in a standard model of the marriage market ...
Gould, Eric D., Moav, Omer, Simhon, Avi
core   +1 more source

Unvollendetes: the Oxford Plato lexicon [PDF]

open access: yes, 2007
In one obvious sense this paper is a misfit within a book that otherwise charts so much achievement. The unfinished project that it describes occupied the attention of two Scottish professors and, in its later reincarnation, a distinguished German ...
Whitaker, G.
core  

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