Engineering miRNA features into siRNAs: Guide-strand bulges are compatible with gene repression
Molecular Therapy: Nucleic Acids, 2022 Synthetic siRNA guide strands are typically designed with perfect complementarity to the passenger strand and the target mRNA. We examined whether siRNAs with intentional guide-strand bulges are functional in vitro and in vivo. Importantly, this was done
Judith Hauptmann +4 more
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Digital transformation and post-Covid-19 education in South Africa: a review of literature
South African Computer Journal, 2023 Little thought or speculation was given to the possibilities of digital transformation for basic education until the global Covid-19 pandemic acted as a catalyst for digital transformation in education.
Silence Chomunorwa +2 more
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Educator perspectives on the use of technology in schools in previously disadvantaged communities
South African Computer Journal, 2022 Technology plays a crucial role in education and many other sectors of the economy. The national lockdown caused by the Covid-19 pandemic has made apparent the importance of technology in education, with schools that adopted technologies continuing with ...
Silence Chomunorwa +2 more
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Less Is More: Novel Hepatocyte-Targeted siRNA Conjugates for Treatment of Liver-Related Disorders
Molecular Therapy: Nucleic Acids, 2020 N-acetyl-galactosamine (GalNAc) conjugation enhances liver specificity for therapeutic oligonucleotides. Here we report on a novel design with improved activity and stability compared with a triantennary design.
Adrien Weingärtner +4 more
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The Relationship Between Corporate Identity and Organizational Silence [PDF]
مطالعات مدیریت بهبود و تحول, 2017 Organizational silence and corporate identity are challenging concepts for organizations. The the purpose of this research is to investigate the relationship between organizational identity and the organizational silence of Bandar Abbas municipality ...
Hesameddin Kamalzade, Fahime Liaghat
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Cognitive Repesentations about Experiences of Organizational Silence: A Phenomenological Study in The Islamic Culture and Guidance Office of Chaharmahal and Bakhtiari Province [PDF]
مطالعات منابع انسانی, 2020 Background & Purpose: avoiding from expressing ideas and sharing knowledge and information deprives the organization from a great deal achievements. For this reason, it is necessary to know its causes and consequences of this study was to identify the ...
Abbas Gheadamini +2 more
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Linguistic and Psycholinguistic Aspects of Silence: A Structural Model of Communication
Дискурс, 2021 Introduction. This work examines the role of silence along the lines of the theoretical considerations suggested by L. Wittgenstein and M. Heidegger. It also focuses on the role of communicative silence in each of the six functions of language in the ...
N. F. Shcherbak, V. I. Potienko
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How to Silence Silencing [PDF]
Chemistry & Biology, 2004 Two recent reports describe the stunning crystal structures of complexes between a viral protein that suppresses RNA silencing and a 21 nucleotide small interfering (si)RNA.
openaire +3 more sources
Circuit, 2010 La responsable de ce numéro a rassemblé une collection de six textes d’analyse du compositeur québécois Gilles Tremblay. En annexe, on retrouve une bibliographie chronologique des textes et travaux consacrés à ce créateur.
openaire +2 more sources
Write On, Women! Discovering Personal Skills through Feminist Pedagogy and Narratives
HOW, 2021 In this pedagogical proposal, we utilized Feminist Pedagogy and narratives to reveal women’s skills that they had silenced in their cover letters for employment.
Ana Olga Rallón +1 more
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