Results 61 to 70 of about 1,029,181 (225)

Ayahuasca and Its DMT- and β-carbolines – Containing Ingredients Block the Expression of Ethanol-Induced Conditioned Place Preference in Mice: Role of the Treatment Environment

Frontiers in Pharmacology, 2018
Ayahuasca is a hallucinogenic beverage produced from the decoction of Banisteriopsis caapi (Bc) and Psychotria viridis (Pv), β-carboline- and N,N-dimethyltryptamine(DMT)-containing plants, respectively.
Elisangela G. Cata-Preta, Yasmim A. Serra, Eliseu da C. Moreira-Junior, Henrique S. Reis, Natali D. Kisaki, Matheus Libarino-Santos, Raiany R. R. Silva, Thaísa Barros-Santos, Lucas C. Santos, Paulo C. R. Barbosa, José L. Costa, Alexandre J. Oliveira-Lima, Lais F. Berro, Eduardo A. V. Marinho   +13 more
doaj   +1 more source

Hemorheological and metabolic consequences of renal ischemia-reperfusion and their modulation by N,N-dimethyltryptamine on a rat model [PDF]

, 2018
K
Bidiga, László, Deák, Ádám, Frecska, Ede, Ghanem, Souleiman, Magyar, Zsuzsanna, Mester, Anita, Nemes, Balázs Áron, Németh, Norbert, Pető, Katalin, Somogyi, Viktória, Tánczos, Bence   +10 more
core   +1 more source

Marine Inspired 2-(5-Halo-1H-indol-3-yl)-N,N-dimethylethanamines as Modulators of Serotonin Receptors: An Example Illustrating the Power of Bromine as Part of the Uniquely Marine Chemical Space

Marine Drugs, 2017
In previous studies, we have isolated several marine indole alkaloids and evaluated them in the forced swim test (FST) and locomotor activity test, revealing their potential as antidepressant and sedative drug leads.
Mohamed A. Ibrahim, Abir T. El-Alfy, Kelly Ezel, Mohamed O. Radwan, Abbas G. Shilabin, Anna J. Kochanowska-Karamyan, Howaida I. Abd-Alla, Masami Otsuka, Mark T. Hamann   +8 more
doaj   +1 more source

Nonlinear Pharmacokinetics of 5-Methoxy-N,N-dimethyltryptamine in Mice [PDF]

Drug Metabolism and Disposition, 2011
5-Methoxy-N,N,-dimethyltryptamine (5-MeO-DMT), an abused serotonergic indolealkylamine drug, was placed into Schedule I controlled substance status in the United States as of January 19, 2011. In previous studies, we have shown the impact of monoamine oxidase A and cytochrome P450 2D6 enzymes on 5-MeO-DMT metabolism and pharmacokinetics.
Hong-Wu, Shen, Xi-Ling, Jiang, Ai-Ming, Yu   +2 more
openaire   +2 more sources

Chronic intermittent exposure to ayahuasca during aging does not affect memory in mice

Brazilian Journal of Medical and Biological Research
The Quechua term ayahuasca refers to a beverage obtained from decoctions of the liana Banisteriopsis caapi with leaves of Psychotria viridis. The ritualistic use of ayahuasca is becoming a global phenomenon, with some individuals using this beverage ...
N.F. Correa-Netto, L.S. Coelho, G.S. Galfano, F. Nishide, F. Tamura, M.K. Shimizu, J.G. Santos Junior, A. Linardi   +7 more
doaj   +1 more source

DMT Models the Near-Death Experience

Frontiers in Psychology, 2018
Near-death experiences (NDEs) are complex subjective experiences, which have been previously associated with the psychedelic experience and more specifically with the experience induced by the potent serotonergic, N,N-Dimethyltryptamine (DMT).
Christopher Timmermann, Christopher Timmermann, Leor Roseman, Leor Roseman, Luke Williams, David Erritzoe, Charlotte Martial, Héléna Cassol, Steven Laureys, David Nutt, Robin Carhart-Harris   +10 more
doaj   +1 more source

Novel psychoactive substances of interest for psychiatry [PDF]

, 2015
Novel psychoactive substances include synthetic cannabinoids, cathinone derivatives, psychedelic phenethylamines, novel stimulants, synthetic opioids, tryptamine derivatives, phencyclidine-like dissociatives, piperazines, GABA-A/B receptor agonists, a ...
Corkery, John, Orsolini, Laura, Papanti, Duccio, Schifano, Fabrizio   +3 more
core   +1 more source

Exploring new avenues: Psychedelic‐assisted therapy for young people

British Journal of Clinical Pharmacology, EarlyView.
Rates of mental illness in young people are increasing, whereas the development of novel mental health treatments has not significantly progressed. Psychedelic‐assisted therapy, using substances such as psilocybin and 3,4‐methylenedioxymethamphetamine (MDMA), has shown potential in the treatment of mental illnesses in the adult population, including ...
Ioanna Artemis Vamvakopoulou, Dasha Nicholls, David J. Nutt, Martina Di Simplicio   +3 more
wiley   +1 more source

Registered Clinical Trials of Ayahuasca and DMT: A Scoping Review

Clinical Pharmacology &Therapeutics, EarlyView.
Interest in ayahuasca and its main component, N,N‐Dimethyltryptamine (DMT), has currently moved from historical and experimental use into modern clinical development. Yet, current evidence is fragmented, and systematic mapping of trial methods and design choices remains limited.
Tijana Stojanović, Kent W. Nilsson, Robert Fredriksson, Helgi B. Schiöth, Thiago C. Moulin   +4 more
wiley   +1 more source

Novel Psychoactive Substances 14Recent Progress on Neuropharmacological Mechanisms of Action for Selected Drugs [PDF]

, 2017
A feature of human culture is that we can learn to consume chemical compounds, derived from natural plants or synthetic fabrication, for their psychoactive effects.
Boris B. , Quednow, Christian P. , Müller, Erich, Seifritz, Hassan, Zurina, Johannes, Kornhuber, Kasinather, B. Vicknasingam, Narayanan, Suresh, Oliver G., Bosch, Singh, Darshan   +8 more
core   +1 more source