Results 71 to 80 of about 29,452,007 (238)
СИНТЕЗ НОВЫХ 6-N-ЗАМЕЩЕННЫХ ПУРИНОВЫХ НУКЛЕОЗИДОВ [PDF]
, 2018 New derivatives of purine nucleosides containing the residues of N,N-diethylethylenediamine or N-(2-aminoethyl)pyrrolidine in 6-position of heterobase have been synthesized.
A. V. Konoplich +9 more
core +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Secret supplement to Biweekly Report for May 7, 1954 [PDF]
, 1954 Memorandum detailing a meeting held at Westinghouse on May 6-7, 1954, to clarify mutual problems involved in making Bomarc Ground Control Network compatible with the Lincoln Transition System and to prepare proposals for presentation at a larger meeting ...
Division 6 Research Staff
core
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
Division 6 Biweekly Report, August 14, 1953
, 1953 Bi-weekly progress report of Division 6 research ...
Division 6 Research Staff
core
Changes and additions to laboratory personnel list [PDF]
, 1955 Listed: name, number, room, group.Includes: telephone key and personnel listing.List of changes and additions to Division 6 personnel at Lincoln Laboratory in July ...
Division 6 Administrative Staff
core
, 1997 The novel amino- and iminometallanes (MeAlNR(f))(n) (1) (n = 4, 1a; n = 6, 1b), (Me(2)GaN(H)R(f))(2) (2), (MeGaNR(f))(6) (3), (Me(2)InN(H)R(f))(2) (4), and (MeIn(THF)NR(f))(4) (5) (R(f) = 4-C6(5)H(4)F) have been prepared in high yield by the reaction of ...
Isabel Us??n +5 more
core +1 more source