Results 91 to 100 of about 14,734,718 (295)

Engineering Synergistic Intra‐/Intermolecular Conformational Locking via Side‐Chain Branching: A β‐Sheet‐Inspired Strategy for Planar NIR‐II Phototheranostic Aggregates

Advanced Science, EarlyView.
A bio‐inspired side‐chain branching strategy is developed to orchestrate a dual noncovalent conformational locking (NoCL) network, enabling the construction of perfectly planar NIR‐II phototheranostic aggregates. Such structural precision maximizes light‐harvesting efficiency and optimizes exciton dynamics, ensuring synchronized enhancements in NIR‐II ...
Cheng Lu, Qian Jia, Bo Wu, Chao Li, Ryan T. K. Kwok, Tie‐Gen Chen, Jianwei Sun, Zheng Zhao, Teng‐Teng Chen, Zhongliang Wang, Jacky W. Y. Lam, Ben Zhong Tang   +11 more
wiley   +1 more source

Repression of Virulence in Staphylococcus aureus by 2‐Aminothiol‐Mediated Quorum Quenching

Angewandte Chemie, EarlyView.
Simple analogues of cysteine that can eliminate the native autoinducing peptides (AIPs) of staphylococci extracellularly, before they activate their receptor, and turn off quorum sensing in different Staphylococcus aureus. The elimination of AIPs occurs through a mechanism similar to native chemical ligation (NCL). Further, this strategy showed promise
Bengt H. Gless, Riccardo Milazzo, Martin S. Bojer, Benjamin S. Sereika‐Bejder, Hanne Ingmer, Christian A. Olsen   +5 more
wiley   +2 more sources

Severe Chest Pain due to N-Acetylcysteine-Induced Esophagitis

Case Reports in Medicine, 2019
We report an unusual case of severe chest pain caused by N-acetylcysteine-induced esophagitis. An 81-year-old Chinese man with a history of interstitial lung disease was admitted to our hospital with intermittent arrhythmia that began 5 days ago.
Weihong Wang, Yu Zhang, Yi Liu, Lei Xu, Dingmei Shi   +4 more
doaj   +1 more source

N-acetylcysteine in a Double-Blind Randomized Placebo-Controlled Trial: Toward Biomarker-Guided Treatment in Early Psychosis

Schizophrenia bulletin, 2017
Biomarker-guided treatments are needed in psychiatry, and previous data suggest oxidative stress may be a target in schizophrenia. A previous add-on trial with the antioxidant N-acetylcysteine (NAC) led to negative symptom reductions in chronic patients.
P. Conus, L. Seidman, M. Fournier, L. Xin, M. Cleusix, P. Baumann, C. Ferrari, A. Cousins, L. Alameda, M. Gholam-Rezaee, P. Golay, R. Jenni, T. W. Woo, M. Keshavan, C. Eap, J. Wojcik, M. Cuenod, T. Buclin, R. Gruetter, K. Do   +19 more
semanticscholar   +1 more source

Human Dental Pulp Stem Cell Secretome Restores Ischemic Stroke–Impaired Motor and Cognitive Functions by Reprogramming Redox and Inflammatory Signaling

Advanced Science, EarlyView.
Human dental pulp stem cell secretome emerges as a cell‐free therapeutic strategy for ischemic stroke by reprogramming redox and inflammatory signaling. hDPSC secretome‐derived antioxidant and immunomodulatory factors suppress the TLR4–NOX–ROS–NF‐κB axis, reduce microglial inflammatory responses and apoptosis, and promote neurogenesis, angiogenesis ...
Kyung‐Joo Seong, Sehoon Park, Sun‐Woong Bae, Daseul Kim, Jin Ho Lee, Won‐Seok Choi, Zee‐Yong Park, Ji‐Yeon Jung, Won‐Jae Kim   +8 more
wiley   +1 more source

Repurposing of N-Acetylcysteine for the Treatment of Dengue Virus-Induced Acute Liver Failure

Hepatic Medicine: Evidence and Research, 2020
Gebrehiwot Gebremedhin Tafere, Dawit Zewdu Wondafrash, Filmon Beyenne Demoz Department of Pharmacology and Toxicology, School of Pharmacy, Mekelle University, Mekelle, EthiopiaCorrespondence: Gebrehiwot Gebremedhin Tafere P.O.
Tafere GG, Wondafrash DZ, Demoz FB
doaj  

N-acetylcysteine in the treatment of psychiatric disorders: current status and future prospects

Expert Opinion on Drug Metabolism & Toxicology, 2017
Introduction: N-acetylcysteine (NAC) is widely known for its role as a mucolytic and as an antidote to paracetamol overdose. There is increasing interest in the use of NAC in the treatment of several psychiatric disorders.
A. Minarini, S. Ferrari, M. Galletti, N. Giambalvo, D. Perrone, G. Rioli, G. Galeazzi   +6 more
semanticscholar   +1 more source

Adaptation of Echinococcus Multilocularis to Oxidative Stress Depends on EmPDK‐Mediated Metabolic Reprogramming

Advanced Science, EarlyView.
Metabolic adaption presents a vital survival strategy for E. multilocularis. This study identifies EmPDK as a central metabolic regulator governing glucose metabolic reprogramming. Oxidative stress activates EmHIF1α to induce EmPDK expression. Mechanistic characterization reveals this ROS/EmHIF1α/EmPDK axis drives glycolytic reprogramming to sustain ...
Huijuan Wang, Zhijian Xu, Ye Tian, Yao Zhang, Zhe Cheng, Yanhai Wang   +5 more
wiley   +1 more source

The effect of modulating platelet reactive oxygen species by the addition of antioxidants to prevent clearance of cold-stored platelets

Hematology, Transfusion and Cell Therapy
Background: It is known that the rapid clearance of cold-stored platelets is attributed to various storage lesions, including an abnormal increase in reactive oxygen species when platelets are exposed to cold temperatures.
Rufeng Xie, Yiming Yang, Xueyu Jiang, Li Gao, Juan Sun, Jie Yang   +5 more
doaj   +1 more source

Potent thrombolytic effect of N-Acetylcysteine on arterial thrombi

Circulation, 2017
Background: Platelet cross-linking during arterial thrombosis involves von Willebrand Factor (VWF) multimers. Therefore, proteolysis of VWF appears promising to disaggregate platelet-rich thrombi and restore vessel patency in acute thrombotic disorders ...
Sara Martínez de Lizarrondo, C. Gakuba, Bradley A. Herbig, Y. Repessé, C. Ali, C. Denis, P. Lenting, E. Touzé, S. Diamond, D. Vivien, M. Gauberti   +10 more
semanticscholar   +1 more source