Results 231 to 240 of about 14,734,718 (295)

Complex Contributions of Methylglyoxal to Pain, Axon Degeneration, and Diabetic Peripheral Neuropathy

Journal of Neurochemistry, Volume 170, Issue 8, August 2026.
This work reviews how the metabolic by‐product methylglyoxal may contribute to the development of diabetic peripheral neuropathy (DPN), a common complication of diabetes characterized by nerve damage and chronic pain in the extremities. In diabetes, methylglyoxal levels rise due to increased glucose metabolism and reduced detoxification capacity. While
Gentry Totta‐Griese, Douglas E. Wright
wiley   +1 more source

Pathomechanism of Fever‐Induced Liver Failure in NBAS Deficiency and Treatment Effect of NAC—Observations In Vitro and In Vivo

Liver International, Volume 46, Issue 8, August 2026.
ABSTRACT Background and Aims Pathogenic variants in neuroblastoma amplified sequence (NBAS) gene causes infantile liver failure type 2 (IFLS2; MIM 616483), characterised by recurrent episodes of liver failure triggered by febrile infections. The underlying pathophysiological mechanisms remain incompletely understood. With this work we try to shed light
Tian Sun, Nicole Hammann, Lina Leghlam, Bianca Peters, Cigdem Arikan, Sarah M. Bedoyan, Qian Chen, Tal Dattner, Felix Distelmaier, Alexander Fichtner, Sven F. Garbade, Nedim Hadžić, Robert Hegarty, Andrea Hellwig, Marianne Hørby Jørgensen, Carolin Jentsch, Sabine Jung‐Klawitter, Martin Laass, Elke Lainka, Hannah Münch, Halise Neslihan Önenli Mungan, Moritz Niesert, Stephanie Oehrl, Begona Polo, Knut Schäkel, James E. Squires, Stefan Kölker, Georg F. Hoffmann, Christian Staufner, Dominic Lenz   +29 more
wiley   +1 more source

Long‐term adverse cardiovascular changes induced by cocoa shell extract administration through lactation in fetal undernourished and control rats

Experimental Physiology, Volume 111, Issue 8, Page 3667-3683, 1 August 2026.
Abstract Cocoa shell extract (CSE; rich in antioxidant compounds) administered to adult hypertensive rats exposed to fetal undernutrition (MUN) reduces blood pressure, improving cardiovascular alterations. We aimed to explore lactation as a reprogramming window, evaluating the long‐term effects of CSE supplementation during this period. MUN and control
Santiago Ruvira, Pilar Rodríguez‐Rodríguez, Metee Iampanichakul, Begoña Quintana‐Villamandos, Dolores Morales, David Ramiro‐Cortijo, Silvia M. Arribas   +6 more
wiley   +1 more source

What is the optimal dose of N-acetylcysteine in adult patients with bronchiectasis?-data from the RIBRON registry. [PDF]

J Thorac Dis
Oscullo G, Méndez R, Olveira C, Girón R, García-Clemente M, Máiz L, Sibila O, Golpe R, Rodríguez-Hermosa JL, Barreiro E, Prados C, Rodríguez-Lopez J, de la Rosa D, Martinez-García MÁ.   +13 more
europepmc   +1 more source

Intra-Articular N-Acetylcysteine Reduces Synovitis Without Preventing Cartilage Degeneration in Experimental Osteoarthritis. [PDF]

Biomedicines
Dinç M, Bayrak HÇ, Karasu R, Aykaç B, Soydemir ÖC, Saricetin A.   +5 more
europepmc   +1 more source

N-acetylcysteine for patients with alcohol use disorder, post-traumatic stress disorder, and their co-occurrence: a systematic review of placebo-controlled randomized trials. [PDF]

BMC Psychiatry
Ahmed MAE, Amin M, Abdalla YE, Abdelghani A, Eid N, Samy A, Kassar O, Alsaadany KR, Mansour MEM.   +8 more
europepmc   +1 more source

N-Acetylcysteine Dose and Treatment Duration in High-Risk Acetaminophen Ingestions Treated Within Eight Hours: A Retrospective Cohort Study. [PDF]

J Med Toxicol
Watson CJ, Simpson MD, Saraiya N, Wilkosz CA, Yu MB, Burns MM, Neavyn MJ, Simone KE, Strout TD.   +8 more
europepmc   +1 more source

N-Acetylcysteine Role in Maintaining Renal Function in Cancer Patients with Cisplatin-Based Chemotherapy. [PDF]

Int J Nephrol Renovasc Dis
Prabu OG, Islami NN, Mellenia J, Nugroho P, Rajabto W, Shatri H.   +5 more
europepmc   +1 more source

Dexamethasone and N-acetylcysteine for the prevention of post-embolization syndrome following transarterial chemoembolization in hepatocellular carcinoma: a systematic review and network meta-analysis. [PDF]

Transl Cancer Res
Cao M, Li Z, Xue C.
europepmc   +1 more source

Antioxidant N-Acetylcysteine Facilitates Breast Cancer Metas-Tasis via Immunosuppressive Reprogramming of Neutrophils. [PDF]

Int J Mol Sci
Zhang J, Wang D, Wang H, Wu Q, Liu M, Li Q, Gong Z.   +6 more
europepmc   +1 more source