Results 1 to 10 of about 2,637 (164)

Core 2 β1,6-N-acetylglucosaminyltransferases accelerate the escape of choriocarcinoma from natural killer cell immunity [PDF]

Biochemistry and Biophysics Reports, 2021
Hyperglycosylated human chorionic gonadotropin (H-hCG) is secreted from choriocarcinoma and contains a core2 O-glycan formed by core2 β1,6-N-acetylglucosaminyl transferase (C2GnT).
Kenichi Nakamura, Kaoru Niimi, Eiko Yamamoto, Yoshiki Ikeda, Kimihiro Nishino, Shiro Suzuki, Hiroaki Kajiyama, Fumitaka Kikkawa   +7 more
doaj   +5 more sources

Evolutionary analyses of the animal glycosyltransferase family 54 reveals two β1,4-N-acetylglucosaminyltransferase families [PDF]

iScience
Summary: N-acetylglucosaminyltransferases involved in branched N-glycans synthesis, a major post-translational modification, are gathered in the CAZy glycosyltransferase family 54.
Aoi Morigo, Roxana Elin Teppa, Masamichi Nagae, Hirokazu Yagi, Yasuhiko Kizuka, Anne Harduin-Lepers   +5 more
doaj   +2 more sources

All-trans-retinoic acid modulates ICAM-1 N-glycan composition by influencing GnT-III levels and inhibits cell adhesion and trans-endothelial migration. [PDF]

PLoS ONE, 2012
Changes in the expression of glycosyltransferases directly influence the oligosaccharide structures and conformations of cell surface glycoproteins and consequently cellular phenotype transitions and biological behaviors.
Changguo Chen, Dekun Diao, Liang Guo, Ming Shi, Jie Gao, Meiru Hu, Ming Yu, Lu Qian, Ning Guo   +8 more
doaj   +1 more source

A Knowledge-Based System for Display and Prediction of O-Glycosylation Network Behaviour in Response to Enzyme Knockouts. [PDF]

PLoS Computational Biology, 2016
O-linked glycosylation is an important post-translational modification of mucin-type protein, changes to which are important biomarkers of cancer. For this study of the enzymes of O-glycosylation, we developed a shorthand notation for representing GalNAc-
Andrew G McDonald, Keith F Tipton, Gavin P Davey   +2 more
doaj   +1 more source

Fringe controls naïve CD4(+)T cells differentiation through modulating notch signaling in asthmatic rat models. [PDF]

PLoS ONE, 2012
The ability of Notch signaling to regulate T helper cell development and differentiation has been widely accepted. Fringe, O-fucose-β1,3-N-acetylglucosaminyltransferases modulate Notch receptor expression and promote the Notch signaling pathway through ...
Wen Gu, Weiguo Xu, Tao Ding, Xuejun Guo
doaj   +1 more source

Enzymes for N-Glycan Branching and Their Genetic and Nongenetic Regulation in Cancer

Biomolecules, 2016
N-glycan, a fundamental and versatile protein modification in mammals, plays critical roles in various physiological and pathological events including cancer progression.
Yasuhiko Kizuka, Naoyuki Taniguchi
doaj   +1 more source

GnT1IP-L specifically inhibits MGAT1 in the Golgi via its luminal domain

eLife, 2015
Mouse GnT1IP-L, and membrane-bound GnT1IP-S (MGAT4D) expressed in cultured cells inhibit MGAT1, the N-acetylglucosaminyltransferase that initiates the synthesis of hybrid and complex N-glycans.
Hung-Hsiang Huang, Antti Hassinen, Subha Sundaram, Andrej-Nikolai Spiess, Sakari Kellokumpu, Pamela Stanley   +5 more
doaj   +1 more source

Minimal catalytic domain of N-acetylglucosaminyltransferase V [PDF]

Glycobiology, 2000
UDP-GlcNAc: Manalpha1-6Manbeta-R beta1-6 N-acetylglucosaminyltransferase V (EC 2.4.1.155, GlcNAc-TV) is a Golgi enzyme that substitutes the trimannosyl core in the biosynthetic pathway for complex-type N-linked glycans. GlcNAc-TV activity is regulated by oncogenes frequently activated in cancer cells ( ras, src, and her2/neu ) and by activators of T ...
Korczak B., Le T., Elowe S., DATTI, Alessandro, Dennis J. W.   +4 more
openaire   +3 more sources

N-Acetylglucosaminyltransferase III Antagonizes the Effect of N-Acetylglucosaminyltransferase V on α3β1 Integrin-mediated Cell Migration [PDF]

Journal of Biological Chemistry, 2006
N-acetylglucosaminyltransferase V (GnT-V) catalyzes the addition of beta1,6-GlcNAc branching of N-glycans, which contributes to metastasis. N-acetylglucosaminyltransferase III (GnT-III) catalyzes the formation of a bisecting GlcNAc structure in N-glycans, resulting in the suppression of metastasis.
Yanyang, Zhao, Takatoshi, Nakagawa, Satsuki, Itoh, Kei-ichiro, Inamori, Tomoya, Isaji, Yoshinobu, Kariya, Akihiro, Kondo, Eiji, Miyoshi, Kaoru, Miyazaki, Nana, Kawasaki, Naoyuki, Taniguchi, Jianguo, Gu   +11 more
openaire   +2 more sources

N-acetylglucosaminyltransferase IVa promotes invasion of choriocarcinoma

Oncology Reports, 2017
Gestational trophoblastic neoplasia (GTN) results from the malignant transformation of placental trophoblasts which secrete human chorionic gonadotropin (hCG) as do normal placenta or hydatidiform mole. N-acetylglucosaminyltransferase IV (GnT-IV) is a glycosyltransferase which catalyses the formation of β1,4GlcNAc branches on the mannose core of N ...
Kimihiro, Nishino, Eiko, Yamamoto, Kaoru, Niimi, Yoko, Sekiya, Yoriko, Yamashita, Fumitaka, Kikkawa   +5 more
openaire   +3 more sources