Results 41 to 50 of about 2,637 (164)

Proteomic profiling of porcine seminal extracellular vesicles reveals potential in vivo fertility biomarkers

Andrology, Volume 14, Issue 2, Page 555-570, February 2026.
Abstract Background Predicting male fertility in farm animals remains a challenge. Seminal plasma (SP) contains a high amount of heterogeneous seminal extracellular vesicles (sEVs), believed involved in reproductive processes and maybe key to understanding male fertility.
Isabel Barranco, Pablo Martínez‐Díaz, Ana Parra, María José Martínez‐Alborcia, Xiomara Lucas, Heriberto Rodríguez‐Martínez, Jordi Roca   +6 more
wiley   +1 more source

Evolutional and clinical implications of the epigenetic regulation of protein glycosylation [PDF]

, 2011
Protein N glycosylation is an ancient posttranslational modification that enriches protein structure and function. The addition of one or more complex oligosaccharides (glycans) to the backbones of the majority of eukaryotic proteins makes the ...
A Alavi, A Harduin-Lepers, A Helenius, A Knežević, A Knežević, A Tsuchida, A Varki, A Varki, A Varki, AV Nairn, CA Reis, CB Lebrilla, D Calo, D Skropeta, DH Dube, E Dabelsteen, E Weerapana, EA Partridge, EJ Richards, F Nimmerjahn, G Lauc, G Lauc, H Ito, HD Morgan, HH Freeze, HH Freeze, I Brockhausen, IG Ovsyannikova, IO Potapenko, J Serpa, JD Esko, JD Marth, JH Ko, JN Arnold, JR Bishop, JS Axford, JW Dennis, JW Dennis, K Drickamer, K Miyazaki, K Ohtsubo, KG Hagen Ten, KL Abbott, KW Marek, LV Hooper, M Dalziel, M Pučić, MA Haeuptle, MA Hollingsworth, MM Fuster, N Dhiman, N Taniguchi, N Taniguchi, O Gornik, O Gornik, P Gagneux, PR Crocker, R Apweiler, R Kannagi, RD Cummings, RL Shields, RM Anthony, RM Anthony, RS Brown, RT Lee, S Iida, S Preithner, U Syrbe, V Zoldoš, VK Rakyan, Y Ide, YI Kawamura, YS Kim   +72 more
core   +2 more sources

Biomarkers in patients with clinical signs of mild cognitive impairment or mild Alzheimer's disease but without amyloid deposits on positron emission tomography: Results from Bio‐Hermes Study participants

Alzheimer's &Dementia, Volume 22, Issue 1, January 2026.
Abstract INTRODUCTION Alzheimer's disease (AD) study participants may present with cognitive impairment who do not have brain amyloid deposits (Aβ−). Identifying predictive biomarkers for non‐amyloid‐related CI may provide better screening tests for trials seeking only CI Aβ+ participants and new therapy targets.
Richard C. Mohs, Douglas W. Beauregard, Lynne Hughes, Cyndy B. Cordell, Allan I. Levey, Saima Rathore, Nicholas T. Seyfried, Erik C. B. Johnson, Jessie Nicodemus‐Johnson, Joshua Christensen, Robin Wolz, John Dwyer   +11 more
wiley   +1 more source

Posttranslational modifications of heterologous proteins expressed in Nicotiana benthamiana

Plant Biotechnology Journal, Volume 24, Issue 1, Page 44-54, January 2026.
Summary The success of Nicotiana benthamiana as a workhorse for heterologous protein production is closely linked to its accessibility and tolerance to genetic manipulation, allowing efficient engineering of posttranslational protein modifications (PTMs) that are critical for the function and stability of heterologous proteins.
Kathrin Göritzer, Somanath Kallolimath, Richard Strasser   +2 more
wiley   +1 more source

First Step Towards the Humanisation of Protein N‐Glycosylation in Chlamydomonas reinhardtii Through Heterologous Expression of α(1,2)‐Mannosidases

Plant Biotechnology Journal, EarlyView.
C. Plasson, J. Balieu, P. Lerouge, M. Bardor, E. Mathieu‐Rivet   +4 more
wiley   +1 more source

Molecular Mechanisms of Plant Growth–Promoting Rhizobacteria (PGPR) in Biofertilization and Disease Suppression of Crops

International Journal of Agronomy, Volume 2026, Issue 1, 2026.
Plant growth–promoting rhizobacteria (PGPR) are beneficial soil bacteria that colonize the rhizosphere and enhance plant growth through direct and indirect mechanisms, including nutrient solubilization, phytohormone production, suppression of phytopathogens, and activation of plant defense mechanisms.
Etsay Mesele, Gebremedhin Gebreslassie, Ashenafi Teklay Yaekob, Tesfakiros Semere, Maria Serrano   +4 more
wiley   +1 more source

Integrated trajectories of systolic and diastolic function differentially associate with risk for heart failure with preserved and reduced ejection fraction and proteomic profiles

European Journal of Heart Failure, Volume 27, Issue 12, Page 2906-2917, December 2025.
Graphical overview of derivation and testing of multiparametric trajectories of cardiac function. This study identified six trajectories of LV systolic and diastolic function from mid‐ to late‐life. Predicted trajectory from single echocardiogram identified four trajectories at differential risk for HFpEF and HFrEF.
Anne Marie Reimer Jensen, James C. Ross, Victoria Arthur, Michael E. Hall, Kunihiro Matsushita, Brandon Lennep, Pamela L. Lutsey, Tor Biering‐Sørensen, Amil M. Shah   +8 more
wiley   +1 more source

A Bioorthogonal and Programmable Bacterial Delivery System for Spatiotemporally Targeted Therapy of Solid Tumors

Exploration, Volume 5, Issue 6, December 2025.
We developed a spatiotemporal targeting oncolytic bacterial therapy system, the STEPT (spatiotemporal targeting EcN‐pfo terminator) system, which injects azide hyaluronic acid hydrogel into tumors to capture DBCO‐labeled engineered Escherichia coli Nissle 1917 (EcN).
Yu‐Jia Wang, Wen‐Jie Jiang, Hua‐Jun Zhao, Jian‐Qun Deng, Yi‐Min Cai, Yi Li, Xiao‐Lin Meng, Jin Hou, Feng‐Shan Wang, Ju‐Zheng Sheng   +9 more
wiley   +1 more source

Differential gene expression in Chorthippus parallelus (Zetterstedt, 1821) (Orthoptera: Acrididae: Gomphocerinae) induced by Wolbachia infection

Insect Science, Volume 32, Issue 6, Page 2105-2124, December 2025.
Distinct lineages of the grasshopper Chorthippus parallelus (Orthoptera: Acrididae) form a well‐known hybrid zone (HZ) in the Pyrenees mountain range; the Iberian endemism C. p. erythropus (Cpe) and the subspecies C. p. parallelus, (Cpp) widely distributed throughout the rest of Europe. Both subspecies differ in diverse traits, including the strains of
Patricia Jiménez‐Florido, Mónica Aquilino, David Buckley, José L. Bella, Rosario Planelló   +4 more
wiley   +1 more source

CRISPR/Cas9‐Mediated Knockouts of the ALG3 and GNTI in N. benthamiana and Their Application to Pharmaceutical Production

Plant Biotechnology Journal, Volume 23, Issue 12, Page 5894-5916, December 2025.
ABSTRACT N‐Glycosylation critically influences the efficacy, safety and pharmacokinetic properties of biopharmaceuticals. Plant expression platforms offer multiple advantages for the production of N‐glycosylated proteins, but their use is impeded by the presence of plant‐specific N‐glycan epitopes, which raise concerns of possible immunogenicity to ...
Dolgormaa Bataa, Hiroyuki Kajiura, Reimi Lai Sang Sawada‐Choi, Yukino Yamashita, Takeshi Ishimizu, Ryo Misaki, Atsushi Takeda, Kazuhito Fujiyama   +7 more
wiley   +1 more source