Results 101 to 110 of about 13,471,027 (144)
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Age-Related Pharmacokinetics of N-Acetylprocainamide in Rats
Journal of Pharmaceutical Sciences, 1983The pharmacokinetics of N-acetylprocainamide, administered orally or intravenously, were studied in 3-, 6-, and 12-month-old rats using a two-way crossover study design. At 3, 6, and 12 months of age, the half-life values of N-acetylprocainamide were 1.66, 1.82, and 2.29 hr, respectively; the apparent volumes of distribution were 4.75, 3.35, and 1.98 ...
A, Yacobi +4 more
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Effects of N-acetylprocainamide as compared with procainamide in isolated rat atria
European Journal of Pharmacology, 1975The actions of procainamide and its major metabolite N-acetylprocainamide were tested and compared on isolated rat atria. While procainamide exerted a negative chronotropic and iontropic effect, N-acetylprocainamide had the opposite effect. It is suggested that a N-acetylprocainamide-induced increase in myocardial work can counteract the negative ...
Helge Refsum, Helge Refsum
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Clinical pharmacology and antiarrhythmic efficacy of N-acetylprocainamide
The American Journal of Cardiology, 1981Eleven patients with chronic ventricular arrhythmias took part in a study of N-acetylprocainamide (NAPA), the major metabolite of procainamide, in order to characterize further NAPA's clinical pharmacology and antiarrhythmic action. The frequency of ventricular arrhythmia on 24 hour ambulatory electrocardiographic recordings was comparable on ...
R A, Winkle +3 more
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Electrophysiologic effects of N-acetylprocainamide in human beings
The American Journal of Cardiology, 1981The electrophysiologic properties of N-acetylprocainamide (NAPA) were studied in 10 patients undergoing cardiac catheterization. Each patient received two successive intravenous infusions: one loading infusion over 15 minutes and one maintenance infusion at a slower rate for 30 minutes.
P, Jaillon +4 more
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N-acetylprocainamide and ischemia-induced ventricular fibrillation in the dog
European Journal of Pharmacology, 1979Open-chest dogs anesthetized with pentobarbital were treated with saline or N-acetylprocainamide (20 mg/kg, i.v.) 10 min prior to simultaneous ligation of the left anterior descending and septal coronary arteries. Ventricular fibrillation occurred in 20 of 26 control dogs but in only 6 of 15 dogs treated with N-acetylprocainamide (P less than 0.05 ...
R D, Reynolds, B L, Kamath
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Hemodynamic effects of N-acetylprocainamide in heart disease
Clinical Pharmacology and Therapeutics, 1982In six normal subjects and 6 patients with primary cardiomyopathy, left ventricular performance was evaluated at rest and during isometric handgrip exercise after 4 days of oral N-acetylprocainamide (NAPA) at each of the three dosage levels (3, 4, 5, and 6 gm/day).
M H, Crawford +5 more
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Trimethoprim alters the disposition of procainamide and N-acetylprocainamide
Clinical Pharmacology and Therapeutics, 1988The steady-state pharmacokinetics and pharmacodynamics of procainamide and its active N-acetyl metabolite (NAPA) were assessed alone and in combination with trimethoprim. Eight healthy men received oral sustained-release procainamide, 500 mg every 6 hours for 3 days, alone and with oral trimethoprim, 200 mg daily for 4 days.
T, Kosoglou, M L, Rocci, P H, Vlasses
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Tissue distribution of N-acetylprocainamide in rats.
Drug Metabolism and Disposition, 1981The purpose of this study was to determine the distribution of N-acetylprocainamide (NAPA) in heart, kidney, and liver tissues of rats and their relationship to the plasma concentration after intravenous administration of the drug (100 mg/kg) to 24 Charles River rats. A specific HPLC procedure was used.
A, Yacobi +3 more
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Comparative Vagolytic Effects of Procainamide and N- Acetylprocainamide in the Dog
Journal of Cardiovascular Pharmacology, 1983Procainamide exerts vagolytic effects which are deleterious in clinical therapy for supraventricular arrhythmias. The purpose of the present study was to determine if N-acetylprocainamide (NAPA), an active metabolite of procainamide which has been proposed as an effective and less toxic alternative, would exert an equivalent degree of vagal blockade ...
D L, Pearle, J D, Souza, R A, Gillis
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The Inotropic Actions of N-Acetylprocainamide: Blockade and Reversal by Propranolol
Angiology, 1986The inotropic actions of N-acetylprocainamide (NAPA) were studied in chloralose-urethane anesthetized dogs. Myocardial contractile force was measured with a Walton-Brodie strain gauge sutured to the right ventricle. A low-dose NAPA infusion (12 mg/kg i.v.) increased myocardial force by a maximum of 11.6±2.4% (mean±SEM), whereas a high dose of NAPA (60 ...
J J, Lertora, L W, King, K A, Donkor
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