Results 121 to 130 of about 13,471,027 (144)

N-Acetylprocainamide kinetics after single and repeated oral doses

Clinical Pharmacology and Therapeutics, 1982
The kinetic behavior of N-acetylprocainamide (NAPA) was studied after single and repeated oral doses in six healthy subjects and five patients with cardiomyopathy. Renal clearance (CLR) of NAPA was lower in patients than in normal subjects after an initial 1-gm dose (1.3 +/- 0.4 [x +1- SD] and 2.7 +/- 0.4 ml . min-1 .
T M, Ludden, M H, Crawford
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Intravenous N-acetylprocainamide disposition kinetics in coronary artery disease

Clinical Pharmacology and Therapeutics, 1980
N-Acetylprocainamide (NAPA) disposition kinetics was studied in eight patients with coronary artery disease. NAPA was given over a 45-min period by intravenous infusion, and blood samples were drawn at specified times for 24 hr. NAPA plasma levels were determined by a specific high-pressure liquid chromatography (HPLC) procedure and the concentration ...
R E, Kates, P, Jaillon, D S, Rubenson, R A, Winkle   +3 more
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Effect kinetics of N-acetylprocainamide-induced QT interval prolongation

Clinical Pharmacology and Therapeutics, 1987
We attempted to correlate clinical response with the effects of N-acetylprocainamide (NAPA) on the QT interval in five patients with stable chronic ventricular arrhythmias. A 15 mg/kg dose of NAPA was administered and a pharmacokinetic-pharmacodynamic model was used to relate plasma NAPA concentrations to changes in corrected QT interval (QTc).
A A, Piergies, T I, Ruo, E M, Jansyn, S M, Belknap, A J, Atkinson   +4 more
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N‐acetylprocainamide levels in patients with end‐stage renal failure

Clinical Pharmacology & Therapeutics, 1976
Serum concentrations of pro cain amide (PA) and N‐acetylprocainamide (NAPA) were measured by fluorometry in subjects with normal renal function (n = 4) and in patients with end‐stage renal failure (n = 3) after administration of 6.5 mg/kg of PA · HCI orally.
T P, Gibson, E J, Matusik, W A, Briggs
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Trimethoprim Inhibition of the Renal Clearance of Procainamide and N-Acetylprocainamide

Archives of Internal Medicine, 1989
• To test the effect of trimethoprim (an antibiotic commonly administered with sulfamethoxazole) on the disposition of the antiarrhythmic procainamide hydrochloride and its active metabolite N-acetylprocainamide, 10 healthy men received 1 g of procainamide hydrochloride orally on two occasions, coadministered with placebo or trimethoprim (100 mg twice ...
P H, Vlasses, T, Kosoglou, S L, Chase, A J, Greenspon, S, Lottes, E, Andress, R K, Ferguson, M L, Rocci   +7 more
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Antiarrhythmic efficacy of N‐acetylprocainamide in patients with premature ventricular contractions

Clinical Pharmacology & Therapeutics, 1976
Oral administration ofa 1.5‐gm dose of N‐acetylprocainamide (NAPA) to 9 patients with premature ventricular contractions (PVCs) confirmed previous indirect evidence that this metabolite of procainamide has antiarrhythmic efficacy and potency comparable to those of procainamide.
W K, Lee, J M, Strong, R F, Kehoe, J S, Dutcher, A J, Atkinson   +4 more
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An Evaluation of the TDx  Fluorescence Polarization Immunoassays for Procainamide and n-Acetylprocainamide

Journal of Analytical Toxicology, 1985
The TDX fluorescence polarization assays (FPIA) for procainamide (PA) and n-acetylprocainamide (NAPA) were evaluated. Coefficients of variation for within- and between-assay precision studies were less than 6%. Both methods correlated well with a referenced HPLC technique; r2 values for PA and NAPA were 0.980 and 0.986, respectively.
P K, Sonsalla, R R, Bridges, T A, Jennison, C M, Smith   +3 more
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Improved Liquid Chromatographic Determination of Procainamide and N-Acetylprocainamide in Serum

Therapeutic Drug Monitoring, 1983
A liquid chromatographic method for the determination of procainamide (PA) and N-acetylprocainamide (NAPA) in serum has been developed. This method utilizes isocratic conditions, ambient temperature, and a conventional fixed-wavelength 280-nm detector.
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Effective plasma concentration of N-acetylprocainamide in rats.

Research communications in chemical pathology and pharmacology, 1979
Six groups of rats received saline or N-Acetylprocainamide (NAPA) 2--50 mg/kg, intraperitoneally. Thirty minutes later heart rates were measured and simultaneously a blood sample was withdrawn from each rat. There was a linear relationship between plasma concentrations and the administered doses, suggesting linear pharmacokinetics for NAPA.
A, Yacobi, R W, Krasula, C M, Lai, B L, Kamath   +3 more
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The reversible biotransformation of N-acetylprocainamide in the rhesus monkey.

Arzneimittel-Forschung, 1978
The specific activity of 14C-N-acetylprocainamide (14C-NAPA) was measured in the 24-h urine of two rhesus monkeys given the labelled drug i.v. Specific activity was found to decrease by 15.8% from the original value. This was attributed to an in vivo biotransformation of NAPA to procainamide (PCA) and reacetylation of PCA back to NAPA before it was ...
T L, Ding, E T, Lin, L Z, Benet
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