Results 141 to 150 of about 614 (173)

The Inotropic Actions of N-Acetylprocainamide: Blockade and Reversal by Propranolol

Angiology, 1986
The inotropic actions of N-acetylprocainamide (NAPA) were studied in chloralose-urethane anesthetized dogs. Myocardial contractile force was measured with a Walton-Brodie strain gauge sutured to the right ventricle. A low-dose NAPA infusion (12 mg/kg i.v.) increased myocardial force by a maximum of 11.6±2.4% (mean±SEM), whereas a high dose of NAPA (60
J J, Lertora, L W, King, K A, Donkor
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Pharmacokinetics of N-acetylprocainamide in patients profiled with a stable isotope method

Clinical Pharmacology and Therapeutics, 1989
N-Acetylprocainamide (NAPA) absorption and disposition were profiled in five patients with ventricular arrhythmias by the simultaneous intravenous administration of NAPA-13C and oral administration of a 500 mg NAPA hydrochloride tablet. NAPA distribution was modeled with a three compartment mammillary system.
A J, Atkinson, T I, Ruo, A A, Piergies, H C, Breiter, T J, Connelly, G S, Sedek, D, Juan, G L, Hubler, A M, Hsieh   +8 more
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Antiarrhythmic efficacy of N‐acetylprocainamide in patients with premature ventricular contractions

Clinical Pharmacology & Therapeutics, 1976
Oral administration ofa 1.5‐gm dose of N‐acetylprocainamide (NAPA) to 9 patients with premature ventricular contractions (PVCs) confirmed previous indirect evidence that this metabolite of procainamide has antiarrhythmic efficacy and potency comparable to those of procainamide.
W K, Lee, J M, Strong, R F, Kehoe, J S, Dutcher, A J, Atkinson   +4 more
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Effects of N-acetylprocainamide as compared with procainamide in isolated rat atria

European Journal of Pharmacology, 1975
The actions of procainamide and its major metabolite N-acetylprocainamide were tested and compared on isolated rat atria. While procainamide exerted a negative chronotropic and iontropic effect, N-acetylprocainamide had the opposite effect. It is suggested that a N-acetylprocainamide-induced increase in myocardial work can counteract the negative ...
H, Refsum, K, Frislid, P K, Lunde, K H, Landmark   +3 more
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Procainamide and N‐acetylprocainamide kinetics investigated simultaneously with stable isotope methodology

Clinical Pharmacology & Therapeutics, 1977
The pharmacokinetics of procainamide (PA) and N‐acetylprocainamide (NAPA) were compared in 3 normal subjects after simultaneous intravenous injection of PA and NAPA‐13C. The distribution kinetics of both compounds were modeled with a 3‐compartment mamillary system, and it was found that their steady‐state distribution volumes were not significantly ...
J S, Dutcher, J M, Strong, S V, Lucas, W K, Lee, A J, Atkinson   +4 more
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Combined High-Efficiency Hemodialysis and Charcoal Hemoperfusion in Severe N-Acetylprocainamide Intoxication

American Journal of Kidney Diseases, 1992
Several extracorporeal techniques have been used to remove N-acetylprocainamide (NAPA), the major metabolite of procainamide, in patients intoxicated with this substance. We report a patient with life-threatening NAPA intoxication who was rapidly and successfully treated with combined high-efficiency hemodialysis and charcoal hemoperfusion.
P M, Kar, K, Kellner, T S, Ing, D J, Leehey   +3 more
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N-Acetylprocainamide Toxicity

Annals of Internal Medicine, 1987
Excerpt To the editor: The anecdotal experiences reported by Domoto, and colleagues (1) do not warrant the recommendation that continuous arteriovenous hemofiltration be the therapy of choice for t...
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Improved Liquid Chromatographic Determination of Procainamide and N-Acetylprocainamide in Serum

Therapeutic Drug Monitoring, 1983
A liquid chromatographic method for the determination of procainamide (PA) and N-acetylprocainamide (NAPA) in serum has been developed. This method utilizes isocratic conditions, ambient temperature, and a conventional fixed-wavelength 280-nm detector.
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Bioavailability of N-acetylprocainamide from mixed diet in rats.

Research communications in chemical pathology and pharmacology, 1981
The purpose of this study was to determine the bioavailability of N-Acetylprocainamide (NAPA) from mixed diet in rats. Six groups of 8 male Charles River CD rats received NAPA-HCl as follows: Group I, an intravenous dose (mean 21 mg) of 14C-labelled drug.
B L, Kamath, A, Yacobi, S D, Gupta, H, Stampfli, M, Durrani, C M, Lai   +5 more
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Half-life of N-acetylprocainamide in rats

Journal of Pharmaceutical Sciences, 1980
B L, Kamath, A, Yacobi
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