The Janthinobacterium sp. HH01 genome encodes a homologue of the V. cholerae CqsA and L. pneumophila LqsA autoinducer synthases [PDF]
, 2013 Janthinobacteria commonly form biofilms on eukaryotic hosts and are known to synthesize antibacterial and antifungal compounds. Janthinobacterium sp. HH01 was recently isolated from an aquatic environment and its genome sequence was established.
Blokesch, Melanie +20 more
core +10 more sources
Stereochemical insignificance discovered in Acinetobacter baumannii quorum sensing. [PDF]
PLoS ONE, 2012 Stereochemistry is a key aspect of molecular recognition for biological systems. As such, receptors and enzymes are often highly stereospecific, only recognizing one stereoisomer of a ligand.
Amanda L Garner +7 more
doaj +1 more source
Structure and Function of the α‐Hydroxylation Bimodule of the Mupirocin Polyketide Synthase
Angewandte Chemie, Volume 135, Issue 47, November 20, 2023., 2023 Mupirocin is a clinically important polyketide antibiotic bearing a 6‐hydroxy group that is essential for biological activity. NMR spectroscopy, authentic synthetic substrates and mass spectrometry were used to establish the mechanistic steps governing incorporation of this key 6‐hydroxy group by an α‐hydroxylation bimodule that recruits a trans acting
Ashley J. Winter +11 more
wiley +2 more sources
Sensors, 2014 We report the degradation of quorum sensing N-acylhomoserine lactone molecules by a bacterium isolated from a Malaysian marine water sample. MALDI-TOF and phylogenetic analysis indicated this isolate BM1 clustered closely to Labrenzia sp.
Norshazliza Ab Ghani +4 more
doaj +1 more source
Quorum-quenching activity of the AHL-lactonase from Bacillus licheniformis DAHB1 inhibits vibrio biofilm formation in vitro and reduces shrimp intestinal colonisation and mortality [PDF]
, 2014 Vibrio parahaemolyticus is a significant cause of gastroenteritis resulting from the consumption of undercooked sea foods and often cause significant infections in shrimp aquaculture. Vibrio virulence is associated with biofilm formation and is regulated
Shanthi, S. +4 more
core +3 more sources
Sensors, 2014 Bacteria realize the ability to communicate by production of quorum sensing (QS) molecules called autoinducers, which regulate the physiological activities in their ecological niches.
Share Yuan Goh +6 more
doaj +1 more source
Evaluation of a new high-throughput method for identifying quorum quenching bacteria [PDF]
, 2013 Quorum sensing (QS) is a population-dependent mechanism for bacteria to synchronize social behaviors such as secretion of virulence factors. The enzymatic interruption of QS, termed quorum quenching (QQ), has been suggested as a promising alternative ...
Bossier, Peter +6 more
core +2 more sources
Sensors, 2014 A multidrug-resistant clinical bacteria strain GB11 was isolated from a wound swab on the leg of a patient. Identity of stain GB11 as Pseudomonas aeruginosa was validated by using matrix-assisted laser desorption/ionization-time-of-flight mass ...
Huey Jia Cheng +5 more
doaj +1 more source
Non-antibiotic quorum sensing inhibitors acting against N-acyl homoserine lactone synthase as druggable target [PDF]
, 2014 YesN-acylhomoserine lactone (AHL)-based quorum sensing (QS) is important for the regulation of proteobacterial virulence determinants. Thus, the inhibition of AHL synthases offers non-antibiotics-based therapeutic potentials against QS-mediated bacterial
A Dürig +46 more
core +2 more sources
Quorum Quenching Bacillus sonorensis Isolated from Soya Sauce Fermentation Brine
Sensors, 2012 An N-acylhomoserine lactone (AHL)-degrading bacterial strain, L62, was isolated from a sample of fermentation brine of Chinese soya sauce by using rich medium agar supplemented with soya sauce (10% v/v).
Kok-Gan Chan +4 more
doaj +1 more source