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Synthesis, Antibiofilm Activity and Molecular Docking of N-Acylhomoserine Lactones Containing Cinammic Moieties

Bioorganic & Medicinal Chemistry Letters, 2023
We prepared a series of cinnamoyl-containing furanones by an affordable and short synthesis. The nineteen compounds hold a variety of substituents including electron-donating, electron-withdrawing, bulky and meta-substituted phenyls, as well as heterocyclic rings. Compounds showed antibiofilm activity in S. aureus, K.
Ángel Ramírez-Trinidad   +5 more
openaire   +2 more sources

BpiB05, a novel metagenome-derived hydrolase acting on N-acylhomoserine lactones

Journal of Biotechnology, 2011
The N-acyl-homoserine lactones (N-AHLs) play an important role in bacterial cell-cell signaling. Up to date, however, only a few different experimentally proven classes of N-AHL ring-cleaving enzymes are known. Here we report on the isolation and biochemical characterization of a novel hydrolase derived from the soil metagenome and acting on N-AHLs ...
P. Bijtenhoorn   +6 more
openaire   +3 more sources

Plants genetically modified to produce N-acylhomoserine lactones communicate with bacteria

Nature Biotechnology, 1999
N-acylhomoserine lactones (AHLs) play a critical role in plant/microbe interactions. The AHL, N-(3-oxohexanoyl)-L-homoserine lactone (OHHL), induces exoenzymes that degrade the plant cell wall by the pathogenic bacterium Erwinia carotovora. Conversely, the antifungal activity of the biocontrol bacterium Pseudomonas aureofaciens 30-84 is due (at least ...
Andrew Wallace   +6 more
openaire   +3 more sources

Degradation of N-acylhomoserine lactones, the bacterial quorum-sensing molecules, by acylase

Journal of Biotechnology, 2003
Porcine kidney acylase I was shown to be able to deacylate N-acylhomoserine lactones, a family of chemicals employed by Gram-negative bacteria as quorum-sensing molecules for cell population density-dependent growth (such as biofilm formation). The enzyme transformed both N-butyryl-and N-octanoyl-L-homoserine lactones into L-homoserine.
Feng, Xu   +4 more
openaire   +3 more sources

N-acylhomoserine lactone-degrading Bacillus strains isolated from aquaculture animals

Aquaculture, 2011
Abstract Infections caused by antibiotic-resistant pathogenic bacteria can cause considerable losses in aquaculture. Many aquaculture pathogens regulate the expression of virulence genes through quorum sensing, bacterial cell-to-cell communication with small signal molecules. N-acyl homoserine lactones (AHLs) are the most extensively studied class of
Peter De Schryver   +6 more
openaire   +2 more sources

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