Results 61 to 70 of about 3,621 (171)

Microfluidics-based liquid chromatography/mass spectrometry multiple reaction monitoring approach for the relative quantification of Burkholderia cenocepacia secreted virulence factors [PDF]

, 2018
Rationale: Burkholderia cenocepacia is an opportunistic pathogen that is commonly isolated from patients with cystic fibrosis (CF). Quorum sensing has been suggested to play a role in the activity of type II and type VI secretion systems and the release ...
Daled, Simon, De Waele, Stijn, Deforce, Dieter, Depluverez, Sofie, Devreese, Bart, Planckaert, Sören, Schoovaerts, Jolien   +6 more
core   +2 more sources

Diversity‐Oriented Synthesis and Antibiofilm Evaluation of Furan‐2‐Carboxamides

ChemMedChem, Volume 20, Issue 9, May 5, 2025.
Navigating through the chemical space of antibiofilm agents! Furan‐2‐carboxamides inhibit the production of this extracellular shield in Pseudomonas aeruginosa by modulating the linkers and substituents of the central core. The discovery offers a solution to the metabolically unstable antibiofilm agents based on furanones, leading to the design of more
Ana C. Muñoz‐Estrada, Cesar E. Tovar‐Roman, Carlos D. García‐Mejía, Rodolfo García‐Contreras, Eduardo Hernández‐Vázquez   +4 more
wiley   +1 more source

Characteristics of N-Acylhomoserine Lactones Produced by Hafnia alvei H4 Isolated from Spoiled Instant Sea Cucumber

Sensors, 2017
This study aimed to identify N-acylhomoserine lactone (AHL) produced by Hafnia alvei H4, which was isolated from spoiled instant sea cucumber, and to investigate the effect of AHLs on biofilm formation.
Hong-Man Hou, Yao-Lei Zhu, Jia-Ying Wang, Feng Jiang, Wen-Yan Qu, Gong-Liang Zhang, Hong-Shun Hao   +6 more
doaj   +1 more source

Rice and bean AHL-mimic quorum-sensing signals specifically interfere with the capacity to form biofilms by plant-associated bacteria [PDF]

, 2013
Many bacteria regulate their gene expression in response to changes in their population density in a process called quorum sensing (QS), which involves communication between cells mediated by small diffusible signal molecules termed autoinducers.
Bellogín Izquierdo, Ramón Andrés, Contreras Sánchez-Matamoros, Rocío, Espuny Gómez, María del Rosario, Jiménez Guerrero, Irene, López Baena, Francisco Javier, Ollero Márquez, Francisco Javier, Pérez Montaño, Francisco de Asís, Rodríguez Carvajal, Miguel Ángel   +7 more
core   +1 more source

Synthesis, Cytotoxic Activity, Antiquorum Sensing Effect, Docking and Md Simulation of Novel 1,3‐Disubstituted 2‐Mercapto‐1H‐Benzo[D]Imidazolium Chlorides

Journal of Biochemical and Molecular Toxicology, Volume 39, Issue 4, April 2025.
A series of benzimidazolium chlorides and their 2‐mercapto were successfully synthesized and characterized. Cytotoxic activity assays revealed that certain synthesized compounds exhibited efficacy against cancer cell lines. To investigate the possible mechanism underlying their cytotoxic effects, the binding interactions of the three most active ...
Mohammad Mavvaji, Muhammed Tilahun Muhammed, Ebru Onem, Halime Güzin Aslan, Sadeq K. Alhag, Senem Akkoc   +5 more
wiley   +1 more source

N-acetylglucosamine inhibits LuxR, LasR and CviR based quorum sensing regulated gene expression levels

Frontiers in Microbiology, 2016
N-acetyl glucosamine, the monomer of chitin, is an abundant source of carbon and nitrogen in nature as it is the main component and breakdown product of many structural polymers. Some bacteria use N-acyl-L-homoserine lactone (AHL) mediated quorum sensing
Onder Kimyon, Zehra Ipek Uluturk, Shashidhar Nizalapur, Matthew Lee, Samuel K Kutty, Sabrina Beckmann, Naresh Kumar, Mike Manefield   +7 more
doaj   +1 more source

Biofilm formation in cardiovascular infection and bioengineering approaches for treatment and prevention

MedComm – Biomaterials and Applications, Volume 4, Issue 1, March 2025.
Biofilm‐related infections in cardiovascular system involve infective endocarditis, prosthetic heart valve endocarditis as well as cardiac device‐associated infections. There are still challenges remaining in the treatment of biofilm‐related infections in cardiovascular system.
Qi Tong, Qiyue Xu, Jie Cai, Yiren Sun, Zhengjie Wang, Yongjun Qian   +5 more
wiley   +1 more source

Classifying the Topology of AHL-Driven Quorum Sensing Circuits in Proteobacterial Genomes

Sensors, 2012
Virulence and adaptability of many Gram-negative bacterial species are associated with an <em>N</em>-acylhomoserine lactone (AHL) gene regulation mechanism called quorum sensing (QS).
Sándor Pongor, Vittorio Venturi, Borisz Galbáts, Zsolt Gelencsér, Kumari Sonal Choudhary, Bruna Goncalves Coutinho, Sanjarbek Hudaiberdiev   +6 more
doaj   +1 more source

Novel approaches to the treatment of Pseudomonas aeruginosa infections in cystic fibrosis [PDF]

, 2012
Pseudomonas aeruginosa chronically infects patients with cystic fibrosis and is associated with greater morbidity. There has been limited progress on the clinical development of new antibiotics with novel modes of action.
Cámara, Miguel, Hurley, M.N., Smyth, Alan R.   +2 more
core   +2 more sources

Quercetin Exhibits Broad‐Spectrum Antibiofilm and Antiquorum Sensing Activities Against Gram‐Negative Bacteria: In Vitro and In Silico Investigation Targeting Antimicrobial Therapy

Canadian Journal of Infectious Diseases and Medical Microbiology, Volume 2025, Issue 1, 2025.
Quercetin (QC), a flavonoid abundant in fruits and vegetables, has garnered attention for its potential therapeutic properties. In this study, we investigated the antibiofilm and antiquorum sensing (QS) activities of QC against Gram‐negative bacteria both in vitro and in silico.
Tanvi Shastri, Reem Binsuwaidan, Arif Jamal Siddiqui, Riadh Badraoui, Sadaf Jahan, Nawaf Alshammari, Mohd Adnan, Mitesh Patel, Mahmoud Elhaig   +8 more
wiley   +1 more source