Extension of the Legionella pneumophila sequence-based typing scheme to include strains carrying a variant of the N-acylneuraminate cytidylyltransferase gene [PDF]
Clinical Microbiology and Infection, 2014 Sequence-based typing (SBT) combined with monoclonal antibody subgrouping of Legionella pneumophila isolates is at present considered to be the reference standard during epidemiological investigation of Legionnaires' disease outbreaks. In some isolates of L.
Mentasti, M. +5 more
exaly +5 more sources
Long live the host! Proteomic analysis reveals possible strategies for parasitic manipulation of its social host [PDF]
Molecular Ecology, Volume 32, Issue 21, Page 5877-5889, November 2023., 2023 Parasites with complex life cycles often manipulate the phenotype of their intermediate hosts to increase the probability of transmission to their definitive hosts.
Butter, Falk +7 more
core +2 more sources
Comparative genome analysis reveals important genetic differences among serotype O1 and serotype O2 strains of Y. ruckeri and provides insights into host adaptation and virulence [PDF]
MicrobiologyOpen, Volume 6, Issue 4, August 2017., 2017 Ministerio de Economía y Competitividad, Grant/Award Number: AGL2012-35808 and AGL2015-66018-
Cascales Freire, Desirée +3 more
core +3 more sources
Origin, evolution, and distribution of the molecular machinery for biosynthesis of sialylated lipooligosaccharide structures in Campylobacter coli. [PDF]
Sci Rep, 2018 Campylobacter jejuni and Campylobacter coli are the most common cause of bacterial gastroenteritis worldwide. Additionally, C. jejuni is the most common bacterial etiological agent in the autoimmune Guillain-Barre syndrome (GBS). Ganglioside mimicry by C.
Culebro A +3 more
europepmc +4 more sources
Proteomic Analysis in Valvular Cardiomyopathy: Aortic Regurgitation vs. Aortic Stenosis. [PDF]
Cells, 2023 Left ventricular (LV) reverse remodeling after aortic valve (AV) surgery is less predictable in chronic aortic regurgitation (AR) than in aortic stenosis (AS).
Holst T +9 more
europepmc +3 more sources
Differences in gene expression patterns between cultured and natural Haloquadratum walsbyi ecotypes. [PDF]
Front Microbiol, 2022 Solar crystallizer ponds are characterized by high population density with a relatively simple community structure in terms of species composition. The microbial community in the solar saltern of Santa Pola (Alicante, Spain), is largely dominated by the ...
Rosselli R +4 more
europepmc +4 more sources
Tumor desialylation surpasses anti-PD-L1 checkpoint therapy in restoring anti-tumor immunity in a murine model for colorectal cancer. [PDF]
Int J CancerWhat's new? Our research highlights how tumor sialylation affects tumor growth and reshapes the immune tumor microenvironment in colorectal cancer. We demonstrate for the first time that complete removal of sialic acids from colorectal tumor cells elicits a robust anti‐tumor immune response, but does not enhance anti‐PD‐L1 blockade efficacy.
van der Haar Àvila I +11 more
europepmc +2 more sources
Disruption of sialic acid metabolism drives tumor growth by augmenting CD8+ T cell apoptosis. [PDF]
Int J Cancer, 2019 Sialylated glycan structures are known for their immunomodulatory capacities and their contribution to tumor immune evasion. However, the role of aberrant sialylation in colorectal cancer and the consequences of complete tumor desialylation on anti‐tumor immunity remain unstudied.
Cornelissen LAM +8 more
europepmc +2 more sources
Journal of Neurochemistry, Volume 167, Issue 1, Page 76-89, October 2023., 2023 Sialic acid is a sugar that is commonly present in the brain. Reduced sialic acid biosynthesis in human iPSC‐derived neurons resulted in reduced sialylation and synapse formation, and altered network activity, indicating the necessity of sialic acid for neuronal development.
Rachel Mijdam +6 more
wiley +1 more source
Chemistry – A European Journal, Volume 29, Issue 46, August 15, 2023., 2023 Sialyllactose mimetics showing lectin affinity but resistant to neuraminidase hydrolysis were produced on a gram scale from N‐acyl‐mannosamines using metabolically engineered E. coli cells. Abstract Herein, we describe the efficient gram‐scale synthesis of α2,3‐ and α2,6‐sialyllactose oligosaccharides as well as mimetics from N‐acyl mannosamines and ...
Paul Rivollier +5 more
wiley +1 more source