Results 31 to 40 of about 669,916 (261)

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

The quantum marginal problem for symmetric states: applications to variational optimization, nonlocality and self-testing

New Journal of Physics, 2021
In this paper, we present a method to solve the quantum marginal problem for symmetric d -level systems. The method is built upon an efficient semi-definite program that uses the compatibility conditions of an m -body reduced density with a global n ...
Albert Aloy, Matteo Fadel, Jordi Tura
doaj   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Supersymmetric extension of qKZ-Ruijsenaars correspondence

Nuclear Physics B, 2019
We describe the correspondence of the Matsuo–Cherednik type between the quantum n-body Ruijsenaars–Schneider model and the quantum Knizhnik–Zamolodchikov equations related to supergroup GL(N|M).
A. Grekov, A. Zabrodin, A. Zotov
doaj   +1 more source

Mathematical modeling of some single-pulse space car flights

Известия Томского политехнического университета: Промышленная кибернетика, 2023
This paper examines the movement of a spacecraft launching from the surface of the Earth at different speeds, within the framework of the five-body problem “Sun–Earth–Moon–Mars–a body with negligible mass” with a close approach to the surface of the Moon,
Nikita Yu. Isachenkov
doaj   +1 more source

Unchained polygons and the N-body problem [PDF]

Regular and Chaotic Dynamics, 2009
The simplest solutions of the N-body problem --symmetric relative equilibria-- are shown to be organizing centers from which stem some recently studied classes of periodic solutions. We focus on the relative equilibrium of the equal-mass regular N-gon, assumed horizontal, and study the families of Lyapunov quasi-periodic solutions bifurcating from them
Chenciner, Alain, Fejoz, Jacques
openaire   +4 more sources

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

New Insight of Time-transformed Symplectic Integrator. I. Hybrid Methods for Hierarchical Triples

The Astrophysical Journal
Accurate N -body simulations of multiple systems such as binaries and triples are essential for understanding the formation and evolution of interacting binaries and binary mergers, including gravitational wave sources, blue stragglers, and X-ray ...
Long Wang
doaj   +1 more source