Results 41 to 50 of about 22,193,544 (297)

Neurocognitive, School‐Based, and Quality of Life Outcomes for Youth With Sickle Cell Disease and Thalassemia: A Scoping Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT The medical burdens of sickle cell disease (SCD) and transfusion‐dependent β‐thalassemia (TDT) are chronic and cumulative, even in children. Yet the effects expand beyond medications and healthcare visits due to their impacts on school attendance, academic performance, and peer engagement.
Mary Ann Etling, Hakim Tokhi, Alexander A. Boucher   +2 more
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Periodic Solutions for N-Body-Type Problems [PDF]

Chinese Annals of Mathematics, Series B, 2020
We consider non-autonomous $N$-body-type problems with strong force type potentials at the origin and sub-quadratic growth at infinity, and using Ljusternik-Schnirelmann theory, we prove the existence of unbounded sequences of critical values for the Lagrangian action corresponding to non-collision periodic solutions.
Li, Fengying, Zhang, Shiqing
openaire   +2 more sources

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Triangular Equilibria in R3BP under the Consideration of Yukawa Correction to Newtonian Potential

Journal of Applied Mathematics, 2022
We study the triangular equilibrium points in the framework of Yukawa correction to Newtonian potential in the circular restricted three-body problem.
M. Javed Idrisi, Teklehaimanot Eshetie, Tenaw Tilahun, Mitiku Kerebh   +3 more
doaj   +1 more source

Recovery of an initial temperature of a one-dimensional body from finite time-observations

Mathematics in Applied Sciences and Engineering, 2023
Under the Dirichlet boundary setting, Aryal and Karki (2022) studied an inverse problem of recovering an initial temperature profile from known temperature measurements at a fixed location of a one-dimensional body and at linearly growing finitely many ...
Ramesh Karki, Chava Shawn, Young You
doaj   +1 more source

Central Configurations of the Curved N-Body Problem [PDF]

Journal of Nonlinear Science, 2018
We consider the $N$-body problem of celestial mechanics in spaces of nonzero constant curvature. Using the concept of locked inertia tensor, we compute the moment of inertia for systems moving on spheres and hyperbolic spheres and show that we can recover the classical definition in the Euclidean case.
Florin Diacu, Cristina Stoica 0002, Shuqiang Zhu   +2 more
openaire   +2 more sources

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source