Results 161 to 170 of about 156,179 (265)

Deep Learning Classification of Pancreatic Cancer Cells Over a Progression of Epithelial to Mesenchymal States by Deformability Cytometry Under Microfluidic Viscoelastic Flows

Advanced Intelligent Systems, EarlyView.
Cancer cells progressively spread over intermediate epithelial‐to‐mesenchymal transition states that cause nuclear enlargement and circular redistribution of filamentous vimentin are classified by deformability cytometry coupled to a multi‐region deep learning model with convolutional feature extraction and attention‐based regional aggregation.
Javad Jarmoshti, Hanyuan Gao, Negin Zeinali, Abdullah‐Bin Siddique, Sara J. Adair, Todd W. Bauer, Matthew J. Lazzara, Xiaoxuan Yang, Nathan S. Swami   +8 more
wiley   +1 more source

Viscoelastic N‑cadherin-like interactions maintain neural progenitor cell stemness within 3D matrices. [PDF]

Nat Commun
Huang MS, LeSavage BL, Ghorbani S, Gilchrist AE, Roth JG, Huerta-López C, Mozipo EA, Navarro RS, Heilshorn SC.   +8 more
europepmc   +1 more source

A Novel Homozygous Nonsense Variant in DCHS1 in a Brazilian Patient With Van Maldergem Syndrome Type 1: Clinical Report and Literature Review

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Van Maldergem syndrome (VMLDS) is an ultra‐rare autosomal recessive disorder characterized by craniofacial dysmorphism, intellectual disability, hypotonia, skeletal anomalies, and feeding difficulties. It is caused by biallelic variants in DCHS1 or FAT4 genes.
Gabriela Roldão Correia‐Costa, Bruna Fagundes Rodrigues Alaite, Vera Lúcia Gil‐da‐Silva‐Lopes, Carlos Eduardo Steiner, Társis Paiva Vieira   +4 more
wiley   +1 more source

N-cadherin antagonism is bronchoprotective in severe asthma models. [PDF]

Sci Adv
Pereira NL, Schaible N, Desai A, Chan EC, Ablooglu AJ, Capuano J, Lin E, An Z, Gebski E, Jester W, Ganesan S, Balenga N, Koziol-White C, Panettieri RA, Choudhury S, Krishnan R, Druey KM.   +16 more
europepmc   +1 more source

Poly(I:C)‐Activated Nasal Fibroblasts Promote Eosinophil Recruitment in CRSwNP

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Chronic rhinosinusitis with nasal polyps (CRSwNP) is characterized by persistent mucosal inflammation and eosinophilic infiltration. Although epithelial and immune cells have been widely studied, the role of nasal fibroblasts in innate immune activation and eosinophil recruitment remains unclear.
Chaewon Shin, An‐Gi Kim, Byeong Min Yu, Woo‐Keun Kwon, Min‐Ho Hwang, Joo‐Hoo Park   +5 more
wiley   +1 more source

The tandem-random transition of cellular patterning: proposed roles of N-cadherin-based orientational cell adhesions in the development, maintenance, and degeneration of the nucleus pulposus. [PDF]

Biol Rev Camb Philos Soc
Wei X, Vo N, Sowa GA.
europepmc   +1 more source

Aortic valve disease: Novel animal models for advancing our understanding of the underlying mechanisms

Animal Models and Experimental Medicine, EarlyView.
Due to the complex pathophysiology of aortic valve disease (AVD) and the resulting lack of effective pharmacotherapy, existing animal models are valuable research tools, but each has its own strengths and limitations. This review systematically surveys the major AVD models, compares their induction methods, pathological features, advantages and ...
Liya Hou, Xue Liu, Wangxing Hu, Xianbao Liu, Wei Zhu   +4 more
wiley   +1 more source

Expression profiles of E-cadherin and N-cadherin in endometriosis and other gynecological diseases towards targeted treatment: a systematic review. [PDF]

Obstet Gynecol Sci
Adamyan L, Pivazyan L, Obosyan L, Kurbatova K, Platonova E, Mailova K, Stepanian A.   +6 more
europepmc   +1 more source

ABCA1 deficiency‐induced cholesterol accumulation aggravates colonic epithelial injury in knockout hamsters

Animal Models and Experimental Medicine, EarlyView.
We established ABCA1‐knockout Syrian golden hamsters as a novel and physiologically relevant model for colitis research. When challenged with a high‐fat diet, ABCA1‐deficient hamsters developed exacerbated colonic inflammation and impaired mucosal barrier integrity, driven by intracellular cholesterol accumulation.
Chang Liu, Jingjie Zheng, Sijing Shi, Jianwen Chen, Geroge Liu, Wei Huang, Xunde Xian, Yuhui Wang, Jianglin Fan, Ping Zhu, Xiawen Yang   +10 more
wiley   +1 more source

N-Cadherin based adhesion and Rac1 activity regulate tension polarization in the actin cortex. [PDF]

Sci Rep
Moazzeni S, Kyker-Snowman K, Cohen RI, Wang H, Li R, Shreiber DI, Zahn JD, Shi Z, Lin H.   +8 more
europepmc   +1 more source