Results 171 to 180 of about 156,179 (265)

Engineered 3D Fibronectin‐Based Environments Modulate the Pathogenic Profile of Arthritic Synovial Fibroblasts

Advanced NanoBiomed Research, EarlyView.
Fibroblast behavior is shaped by the surrounding microenvironment, yet conventional culture systems often fail to capture disease‐relevant phenotypes. Here, platform‐dependent responses of healthy and arthritic synovial fibroblasts are examined across 2D and 3D culture systems. Distinct inflammatory and proliferative signatures emerge, highlighting how
Aneesah Khan, Piaopiao Pan, Yanling Lan, Çağlar Çi̇l, Julia Isakova, Yilin Wang, Theodora Rogkoti, Thanutchaporn Sartyoungkul, James F. C. Windmill, Jonathan William, Manuel Salmeron‐Sanchez, Margaret H. Harnett, Oana Dobre, Miguel A. Pineda   +13 more
wiley   +1 more source

The Abl-interactor Abi suppresses the function of the BRAG2 GEF family member Schizo

Biology Open
Stefanie Lübke, Carina Braukmann, Karl-Heinz Rexer, Lubjinka Cigoja, Pratiti Rout, Susanne F. Önel   +5 more
doaj   +1 more source

Human-specific genomic evolution of a regulatory network enables fine-tuning of N-cadherin gene expression. [PDF]

Cell Mol Life Sci
Erdmann É, Agolli S, Fix S, Cottard F, Keyser C, Zvenigorosky V, Gonzalez A, Haili Z, Kieffer B, Céraline J.   +9 more
europepmc   +1 more source

Covalent Immobilisation of PVA‐MA Hydrogels on Plasma‐Activated Coatings: Achieving Superior Adhesion by Reagent‐Free Formation of a Nanoscale Primer Layer

Advanced NanoBiomed Research, EarlyView.
Robust attachment of hydrogels to solid substrates is critical to success in cell culture where hydrostatic and contractile forces can contribute to delamination of weakly adhered gels. This novel approach forms a nanometer‐scale, reagent‐free hydrogel primer layer to provide improved resistance to delamination of subsequent bulk hydrogel layers in a ...
Sophia C. Franklin, Clara T. H. Tran, Matthew Hadden, David Martinez‐Martin, Laura Poole‐Warren, Marcela M. M. Bilek, Ulises Aregueta Robles, Aaron D. Gilmour   +7 more
wiley   +1 more source

Inhibition of CHI3L1 decreases N-cadherin and VCAM-1 levels in glioblastoma. [PDF]

Pharmacol Rep
Rusak A, Gąsior-Głogowska M, Sargenti A, Krzyżak E, Kotowski K, Mrozowska M, Górnicki T, Kujawa K, Dzięgiel P.   +8 more
europepmc   +1 more source

Gut Health in Ostriches (Struthio camelus): Insights Into Intestinal Structure, Functions, Microbiome, and Improvement Strategies

Animal Research and One Health, EarlyView.
Our paper systematically reviews the intestinal structure, function, and microbiota of ostriches, along with strategies for improving their gut health. We analyze how these factors collectively influence intestinal homeostasis and ostrich welfare, emphasizing probiotics as a promising intervention to enhance gut health, boost population well‐being, and
Zi‐Qun Zhang, Fang‐Fang Guo, Wen‐Juan Du, Meng Li, Aftab Shaukat, Zhu‐Qing Jia, Shu‐Cheng Huang   +6 more
wiley   +1 more source

Dynamin 1-mediated endocytic recycling of glycosylated N-cadherin sustains the plastic mesenchymal state to promote ovarian cancer metastasis. [PDF]

Protein Cell
Cai Y, Guan Z, Tong Y, Zhao W, Zhang J, Peng L, Ip PPC, To SKY, Wong AST.   +8 more
europepmc   +1 more source

Recent Advances in Virus–Host Interactions, Antiviral Bioactive Compounds, and Breeding for Disease Resistance of Porcine Epidemic Diarrhea Virus

Animal Research and One Health, EarlyView.
Basic research on the PEDV infection cycle and virus–host interactions advances the development of anti‐PEDV drugs and disease‐resistant breeding and helps strengthen disease prevention and control while reducing economic losses in the swine industry.
Heyong Wu, Aosi Qi, Shuyu Zhong, Haozhen Du, Shimeng Guo, Hongsheng Ouyang, Hongming Yuan, Daxin Pang, Zicong Xie   +8 more
wiley   +1 more source

ROCK signaling is involved in the entosis of both nonepithelial and epithelial tumors, whereas N‑cadherin is involved in the entosis of nonepithelial tumors. [PDF]

Exp Ther Med
Oi M, Kushibiki R, Kanehira Y, Nishijima Y, Kobayashi S, Saio M.   +5 more
europepmc   +1 more source

T cells, the Next Big Target in Axial Spondyloarthritis?

Arthritis &Rheumatology, EarlyView.
Axial spondyloarthritis (axSpA) is a chronic inflammatory disease characterized by complex immune dysregulation, with T cells playing a central role in its pathogenesis. In this review, we synthesize current knowledge on diverse T cell subsets in axSpA, their pathogenic mechanisms, and emerging therapeutic strategies targeting these cells. We highlight
Mansi K. Aparnathi, Nigil Haroon
wiley   +1 more source