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N-Cadherin—a Potential Target for Psychopharmacology
Neurochemical JournalGlycoprotein N-cadherin (Neuronal cadherin) belongs to the family of calcium-dependent cell adhesion molecules, representing a key element that carries out intercellular contacts in brain neurons. However, it is involved not only in the mechanical connection of neurons, but also influences the specifics of the further development and functional state ...
Y. Y. Firstova, G. I. Kovalev
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N-cadherin-associated proteins in chicken muscle
Differentiation, 1991The development and functional activity of the heart depends on the regulated interaction of cardiac cells. This is in part mediated by cell-cell adhesion molecules such as N-cadherin. N-cadherin belongs to a family of Ca+(+)-dependent, transmembrane, adhesion glycoproteins that promote cell-cell adhesion by molecular self-association extracellularly ...
M J, Wheelock, K A, Knudsen
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Robo is Abl to block N-Cadherin function
Nature Cell Biology, 2002The molecular pathways involved in wiring the brain have just begun to be elucidated. Work in this issue of Nature Cell Biology has uncovered inhibitory interactions between two such pathways: Roundabout (Robo) and N-Cadherin. This discovery provides a potential mechanistic understanding of how pathways are used in a coordinated manner to guide axons.
Mark M, Emerson, David, Van Vactor
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The cleavage of N-cadherin is essential for chondrocyte differentiation
Biochemical and Biophysical Research Communications, 2010The aggregation of chondroprogenitor mesenchymal cells into precartilage condensation represents one of the earliest events in chondrogenesis. N-cadherin is a key cell adhesion molecule implicated in chondrogenic differentiation. Recently, ADAM10-mediated cleavage of N-cadherin has been reported to play an important role in cell adhesion, migration ...
Shigeto, Nakazora +8 more
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N‐cadherin is not essential for limb mesenchymal chondrogenesis
Developmental Dynamics, 2004AbstractThe cell adhesion molecule N‐cadherin is implicated in many morphogenetic processes, including mesenchyme condensation during limb development. To further understand N‐cadherin function, we characterized a new N‐cadherin allele containing the lacZ reporter gene under the regulation of the mouse N‐cadherin promoter.
Yang, Luo +2 more
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A possible role of N-cadherin in thalidomide teratogenicity
Life Sciences, 2000Several experimental findings indicate that the adhesion molecule N-cadherin participates in distinct processes of embryogenesis that spatiotemporarily correlate with high sensitivity to thalidomide. Therefore, we suppose that thalidomide might interfere with N-cadherin-mediated interactions.
A, Thiele +5 more
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N-cadherin expression and function in cultured oligodendrocytes
Developmental Brain Research, 1996N-Cadherin is a major cell adhesion molecule that is expressed in the developing nervous system where it has been implicated in neural migration and axon growth. Recently, a role for N-cadherin in oligodendrocyte differentiation has been identified [23]. Oligodendrocyte precursors adhere to N-cadherin and mature rapidly to produce myelin sheets.
H R, Payne, J J, Hemperly, V, Lemmon
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Traction forces exerted through N‐cadherin contacts
Biology of the Cell, 2006Background information. Mechanical forces play an important role in the organization, growth and function of living tissues. The ability of cells to transduce mechanical signals is governed by two types of microscale structures: focal adhesions, which link cells to the extracellular matrix, and adherens junctions, which link adjacent cells through ...
Ganz, Arthur +6 more
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Current eye research, 1989
N-cadherin was identified in the human lens by its immunological specificity, and concanavalin-A (Con-A) binding. The 135 kd glycoprotein was partially purified from human lens plasma membranes by Con-A affinity column chromatography. In the newborn lens, N-cadherin is distributed equally in amount between cortical and nuclear membranes. It is markedly
P L, Atreya +4 more
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N-cadherin was identified in the human lens by its immunological specificity, and concanavalin-A (Con-A) binding. The 135 kd glycoprotein was partially purified from human lens plasma membranes by Con-A affinity column chromatography. In the newborn lens, N-cadherin is distributed equally in amount between cortical and nuclear membranes. It is markedly
P L, Atreya +4 more
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The N-Cadherin/Catenin Complex in Colon Fibroblasts and Myofibroblasts
Cell Adhesion and Communication, 1999Fibroblasts and myofibroblasts were isolated respectively from normal colon mucosa and from colon cancers. Immunostaining with an antibody against alpha-smooth muscle actin (alpha-SMA) of the tissues of origin and of early passage cultures showed equal proportions of alpha-SMA positive myofibroblasts in vivo as in vitro.
van Hoorde, Leen +2 more
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