The major role of Listeria monocytogenes folic acid metabolism during infection is the generation of N-formylmethionine [PDF]
MBio, 2023 Folic acid and its derivatives (folates) play central roles in one-carbon metabolism, necessary for the synthesis of purines, pyrimidines, and some amino acids.
Daniel Portnoy
exaly +8 more sources
Circulating N-formylmethionine and metabolic shift in critical illness: a multicohort metabolomics study [PDF]
Critical Care, 2022 Background Cell stress promotes degradation of mitochondria which release danger-associated molecular patterns that are catabolized to N-formylmethionine.
Martin Ingi Sigurdsson +9 more
doaj +4 more sources
Listeria monocytogenes folate metabolism is required to generate N-formylmethionine during infection [PDF]
mBio, 2023 Folic acid and its derivatives are required for the synthesis of purines, pyrimidines, and some amino acids. Antifolate antibiotics that target the folic acid metabolism pathway are commonly used for the treatment of listeriosis caused by the ...
Qing Tang, Michelle L. Reniere
doaj +4 more sources
N-formylmethionine-leucyl-phenylalanine protects against irradiation-induced damage to hematopoiesis and intestines [PDF]
Molecular MedicineBackground Ionizing radiation (IR), including radiotherapy, can exert lasting harm on living organisms. While liposaccharide (LPS) offers resistance to radiation damage, it also induces toxic responses.
Zhihua Li +7 more
doaj +4 more sources
Pseudouridine and N-formylmethionine associate with left ventricular mass index: Metabolome-wide association analysis of cardiac remodeling [PDF]
Journal of Molecular and Cellular Cardiology, 2020 Heart failure (HF) is the fastest growing form of cardiovascular disease both nationally and globally, underlining a need to phenotype subclinical HF intermediaries to improve primary prevention.We aimed to identify novel metabolite associations with left ventricular (LV) remodeling, one upstream HF intermediary, among a community-based cohort of ...
Seamus Whelton +2 more
exaly +5 more sources
Development of an enhanced anti-pan-N-formylmethionine-specific antibody
BioTechniquesBoth bacterial and eukaryotic ribosomes can initiate protein synthesis with formylmethionine (fMet), but detecting fMet-bearing peptides and fMet-bearing proteins has been challenging due to the lack of effective anti-pan-fMet antibodies.
Cheol-Sang Hwang +2 more
exaly +5 more sources
Where Does N-Formylmethionine Come from? What for? Where Is It Going? What is the origin of N-formylmethionine in eukaryotic cells? [PDF]
Mol Cells, 2022 - ; 1 ; 1 ; Y ; scie ; scopus ...
Lee CS, Kim D, Hwang CS.
europepmc +5 more sources
N-terminal formylmethionine as a degron and a specific signal in proteostasis and stress adaptation [PDF]
Experimental and Molecular MedicineN-terminal (Nt) methionine formylation, once thought restricted to bacteria and organelles, is now recognized as a stress-inducible initiator modification in the eukaryotic cytosol.
Chang-Seok Lee +2 more
doaj +2 more sources
Association of mental disorders with sepsis: a bidirectional Mendelian randomization study [PDF]
Frontiers in Public HealthBackgroundSubstantial research evidence supports the correlation between mental disorders and sepsis. Nevertheless, the causal connection between a particular psychological disorder and sepsis remains unclear.MethodsFor investigating the causal ...
Yuanzhi Hu +11 more
doaj +2 more sources
Causal effects of metabolites on malignant neoplasm of bone and articular cartilage: a mendelian randomization study [PDF]
Frontiers in GeneticsObjectivePrevious research has demonstrated that metabolites play a significant role in modulating disease phenotypes; nevertheless, the causal association between metabolites and malignant malignancies of bones and joint cartilage (MNBAC)has not been ...
Yongwei Du +5 more
doaj +2 more sources