Results 21 to 30 of about 2,569 (110)

The influence of extracellular tissue on neutrophil function and its possible linkage to inflammatory diseases

Immunity, Inflammation and Disease, 2021
Background: Migration, production of reactive oxygen species (ROS), release of myeloperoxidase (MPO), and NETosis are functional immunological reactions of elementary importance for polymorphonuclear neutrophils (PMN).
Richard F. Kraus, Michael A. Gruber, Martin Kieninger   +2 more
doaj   +1 more source

Mitochondrial DNA variants modulate N-formylmethionine, proteostasis and risk of late-onset human diseases

Nature Medicine, 2021
Mitochondrial DNA (mtDNA) variants influence the risk of late-onset human diseases, but the reasons for this are poorly understood. Undertaking a hypothesis-free analysis of 5,689 blood-derived biomarkers with mtDNA variants in 16,220 healthy donors, here we show that variants defining mtDNA haplogroups Uk and H4 modulate the level of circulating N ...
Cai, Na, Gomez-Duran, Aurora, Yonova-Doing, Ekaterina, Kundu, Kousik, Burgess, Annette I, Golder, Zoe J, Calabrese, Claudia, Bonder, Marc J, Camacho, Marta, Lawson, Rachael A, Li, Lixin, Williams-Gray, Caroline H, ICICLE-PD Study Group, Di Angelantonio, Emanuele, Roberts, David J, Watkins, Nick A, Ouwehand, Willem H, Butterworth, Adam S, Stewart, Isobel D, Pietzner, Maik, Wareham, Nick J, Langenberg, Claudia, Danesh, John, Walter, Klaudia, Rothwell, Peter M, Howson, Joanna MM, Stegle, Oliver, Chinnery, Patrick F, Soranzo, Nicole   +28 more
openaire   +5 more sources

Neutrophils Require Activation to Express Functional Cell-Surface Complement Receptor Immunoglobulin

Frontiers in Immunology, 2022
The phagocytosis-promoting complement receptor, Complement Receptor Immunoglobulin (CRIg), is exclusively expressed on macrophages. It has been demonstrated that expression in macrophages could be modulated by inflammatory mediators, including cytokines.
Annabelle G. Small, Annabelle G. Small, Annabelle G. Small, Annabelle G. Small, Khalida Perveen, Khalida Perveen, Trishni Putty, Trishni Putty, Nikita Patel, Nikita Patel, Patrick Quinn, Patrick Quinn, Mihir D. Wechalekar, Charles S. Hii, Charles S. Hii, Alex Quach, Alex Quach, Antonio Ferrante, Antonio Ferrante, Antonio Ferrante   +19 more
doaj   +1 more source

USE OF SUMO-EXPRESSION SYSTEM AND SUMO-PROTEASE FOR PRODUCTION OF ACTIVE INTERFERON α-2b [PDF]

Biotechnologia Acta
Recombinant proteins production in prokaryotic expression systems is often complicated by need of native, N-terminal formylmethionine free molecule extraction, refolding, and processing.
I-M.M. KLYMKOVYCH, M.M. SKRYNNYK
doaj   +1 more source

Novel Findings From a Metabolomics Study of Left Ventricular Diastolic Function: The Bogalusa Heart Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020
Background Diastolic dysfunction is one important causal factor for heart failure with preserved ejection fraction, yet the metabolic signature associated with this subclinical phenotype remains unknown.
Alexander C. Razavi, Lydia A. Bazzano, Jiang He, Camilo Fernandez, Seamus P. Whelton, Marie Krousel‐Wood, Shengxu Li, Jovia L. Nierenberg, Mengyao Shi, Changwei Li, Xuenan Mi, Jason Kinchen, Tanika N. Kelly   +12 more
doaj   +1 more source

Bioinformatics Approach to Identify Significant Biomarkers, Drug Targets Shared Between Parkinson’s Disease and Bipolar Disorder: A Pilot Study

Bioinformatics and Biology Insights, 2022
Parkinson’s disease (PD) is a neurodegenerative disorder responsible for shaking, rigidity, and trouble in walking and patients’ coordination ability and physical stability deteriorate day by day.
Md. Bipul Hossain, Md. Kobirul Islam, Apurba Adhikary, Abidur Rahaman, Md. Zahidul Islam   +4 more
doaj   +1 more source

Polymorphonuclear Cell Chemotaxis and Suicidal NETosis: Simultaneous Observation Using fMLP, PMA, H7, and Live Cell Imaging

Journal of Immunology Research, 2020
Chemotaxis and the formation of suicidal neutrophil extracellular traps (suicidal NETosis) are key functions of polymorphonuclear cells (PMNs). Neutrophil extracellular traps in particular are known to be significantly involved in the severity of ...
Delou Pai, Michael Gruber, Sophie-Marie Pfaehler, Andre Bredthauer, Karla Lehle, Benedikt Trabold   +5 more
doaj   +1 more source

Tumor Tissue-Specific Biomarkers of Colorectal Cancer by Anatomic Location and Stage

Metabolites, 2020
The progress in the discovery and validation of metabolite biomarkers for the detection of colorectal cancer (CRC) has been hampered by the lack of reproducibility between study cohorts. The majority of discovery-phase biomarker studies have used patient
Yuping Cai, Nicholas J. W. Rattray, Qian Zhang, Varvara Mironova, Alvaro Santos-Neto, Engjel Muca, Ana K. Rosen Vollmar, Kuo-Shun Hsu, Zahra Rattray, Justin R. Cross, Yawei Zhang, Philip B. Paty, Sajid A. Khan, Caroline H. Johnson   +13 more
doaj   +1 more source

Role of the Intracellular Sodium Homeostasis in Chemotaxis of Activated Murine Neutrophils

Frontiers in Immunology, 2020
The importance of the intracellular Ca2+ concentration ([Ca2+]i) in neutrophil function has been intensely studied. However, the role of the intracellular Na+ concentration ([Na+]i) which is closely linked to the intracellular Ca2+ regulation has been ...
Karolina Najder, Micol Rugi, Micol Rugi, Mégane Lebel, Julia Schröder, Leonie Oster, Sandra Schimmelpfennig, Sarah Sargin, Zoltán Pethő, Etmar Bulk, Albrecht Schwab   +10 more
doaj   +1 more source

Additional file 13 of Circulating N-formylmethionine and metabolic shift in critical illness: a multicohort metabolomics study

, 2022
Additional file 13. Significantly Different Metabolites with increased N-formylmethionine at day 0 in both VITdAL-ICU and RoCI Cohorts.
Sigurdsson, Martin Ingi, Kobayashi, Hirotada, Amrein, Karin, Nakahira, Kiichi, Rogers, Angela J., Pinilla-Vera, Mayra, Baron, Rebecca M., Fredenburgh, Laura E., Lasky-Su, Jessica A., Christopher, Kenneth B.   +9 more
openaire   +1 more source