Results 11 to 20 of about 2,569 (110)

Real-time characterisation of microbe-induced inflammation using a novel zebrafish larval corneal injury and infection model [PDF]

Communications Biology
Microbial keratitis (MK) is a major global cause of blindness. Yet, treatment is heavily dependent on antimicrobials with limited options for immunomodulators - despite the critical role of dysregulated immune responses in disease pathogenesis.
Kelvin K. W. Cheng, Carl S. Tucker, Justyna Cholewa-Waclaw, Stephen Mitchell, Fraser Laidlaw, Bethany Mills, Adriano G. Rossi   +6 more
doaj   +2 more sources

Further studies on the initiation of protein synthesis with N-formylmethionine in E. coli extracts. [PDF]

Proceedings of the National Academy of Sciences of the United States of America, 1967
Synthesis of the multitude of different proteins in E. coli, including those of the viruses which infect the bacteria, appears to be initiated with N-formylmethionine.1-4 Extensive studies have been carried out in a number of laboratories to determine the precise mechanism by which synthesis is initiated with this modified amino acid.6-12 The results ...
A E, Economou, T, Nakamoto
exaly   +3 more sources

Cross-recognition of N-formylmethionine peptides is a general characteristic of H2-M3-restricted CD8+ T cells. [PDF]

Infect Immun, 2005
ABSTRACTH2-M3-restricted CD8+T cells can exhibit cross-reactivity to different bacterially derivedN-formylmethionine peptides. The extent of this promiscuity is unclear. We deleted the nonredundant fMIVTLF epitope and found thatListeria monocytogenesstill primed fMIVTLF-specific T cells.
Ploss A, Tran A, Menet E, Leiner I, Pamer EG.   +4 more
europepmc   +4 more sources

Influence of Acute Phase Proteins on Neutrophil Function In Vitro [PDF]

FASEB BioAdvances
As part of a systemic inflammatory response, acute phase proteins (APPs) are released into the blood to support the body's immune response. Once in the bloodstream, the APPs can also interact with immune cells, such as neutrophil granulocytes (PMNs ...
Richard F. Kraus, Isabell Wild, Michael A. Gruber, Martin G. Kees   +3 more
doaj   +2 more sources

Analysis of the prognostic value of mitochondria-related genes in patients with acute myocardial infarction [PDF]

BMC Cardiovascular Disorders
Background Acute myocardial infarction (AMI) is a leading cause of death worldwide. Mitochondrial dysfunction is a key determinant of cell death post-AMI. Preventing mitochondrial dysfunction is thus a key therapeutic strategy.
Jun Qiu, Yiyang Gu
doaj   +2 more sources

Activin A impairs ActRIIA+ neutrophil recruitment into infected skin of mice

iScience, 2021
Summary: Activin A levels are elevated during multiple severe infections and associated with an increased risk of death. However, the role of activin A in bacterial infection is still unclear. Here, we found that activin A levels were increased during S. 
Yan Qi, Lingling Jiang, Chengdong Wu, Jing Li, Heyuan Wang, Shiji Wang, Xintong Chen, Xueling Cui, Zhonghui Liu   +8 more
doaj   +1 more source

Paralytic Impact of Centrifugation on Human Neutrophils

Biomedicines, 2022
Centrifugation is a common step in most of the popular protocols for the isolation of neutrophils from whole blood. Inconsistent results from previous studies on neutrophils may originate from an underestimation of the centrifugation effect, as in ...
Tobias Hundhammer, Michael Gruber, Sigrid Wittmann   +2 more
doaj   +1 more source

Anticodon table of the chloroplast genome and identification of putative quadruplet anticodons in chloroplast tRNAs

Scientific Reports, 2023
The chloroplast genome of 5959 species was analyzed to construct the anticodon table of the chloroplast genome. Analysis of the chloroplast transfer ribonucleic acid (tRNA) revealed the presence of a putative quadruplet anticodon containing tRNAs in the ...
Tapan Kumar Mohanta, Yugal Kishore Mohanta, Nanaocha Sharma   +2 more
doaj   +1 more source

Preterm ETs Are Significantly Reduced Compared with Adults and Partially Reduced Compared with Term Infants

Children, 2022
The release of DNA by cells during extracellular trap (ET) formation is a defense function of neutrophils and monocytes. Neutrophil ET (NET) formation in term infants is reduced compared to adults.
Aila Wirkner, Antje Vogelgesang, Ines Hegge, Anja Lange, Dirk Manfred Olbertz, Bernd Gerber, Matthias Heckmann, Johanna Ruhnau   +7 more
doaj   +1 more source

In vitro neutrophil migration is associated with inhaled corticosteroid treatment and serum cytokines in pediatric asthma

Frontiers in Pharmacology, 2022
Background: Different asthma phenotypes are driven by molecular endotypes. A Th1-high phenotype is linked to severe, therapy-refractory asthma, subclinical infections and neutrophil inflammation.
Solveig Lemmel, Markus Weckmann, Markus Weckmann, Markus Weckmann, Anna Wohlers, Adan Chari Jirmo, Ruth Grychtol, Isabell Ricklefs, Isabell Ricklefs, Gyde Nissen, Gyde Nissen, Anna Bachmann, Shantanu Singh, Juan Caicedo, Thomas Bahmer, Thomas Bahmer, Gesine Hansen, Erika Von Mutius, Klaus F. Rabe, Oliver Fuchs, Oliver Fuchs, Oliver Fuchs, Anna-Maria Dittrich, Bianca Schaub, Christine Happle, Anne E. Carpenter, Matthias Volkmar Kopp, Matthias Volkmar Kopp, Matthias Volkmar Kopp, Tim Becker, Tim Becker, Tim Becker, the ALLIANCE Study Group as part of the German Centre for Lung Research (DZL), Mustafa Abdo, Miguel Alcazar, Thomas Bahmer, Mira Berbig, Heike Biller, Xenia Bovermann, Folke Brinkmann, Mifflin-Rae Calveron, Adan Chari Jirmo, David S. DeLuca, Gesa Diekmann, Anna-Maria Dittrich, Christian Dopfer, Markus Ege, Svenja Foth, Oliver Fuchs, Svenja Gaedcke, Karoline I. Gaede, Ruth Grychtol, Anika Habener, Gesine Hansen, Christine Happle, Christian Herzmann, Alexander Hose, Sabina Illi, Anne-Marie Kirsten, Naschla Kohistani-Greif, Inke R. König, Silke Van Koningsbruggen-Rietschel, Matthias V. Kopp, Johanna Kurz, Katja Landgraf-Rauf, Kristina Laubhahn, Lena Liboschik, Claudia Liebl, Berrit Liselotte Husstedt, Bin Liu, Nicole Maison, Aydin Malik, Carola Marzi, Meike Meyer, Erika Von Mutius, Gyde Nissen, Catharina Nitsche, Frauke Pedersen, Mareike Price, Klaus F. Rabe, Harald Renz, Isabell Ricklefs, Ernst Rietschel, Barbara Roesler, Bianca Schaub, Christina Schauberger, Tom Schildberg, Carsten Schmidt-Weber, Nicolaus Schwerk, Chrysanthi Skevaki, Alena Steinmetz, Laila Sultansei, Marlen Szewczyk, Dominik Thiele, Vera Veith, Gesche Voigt, Benjamin Waschki, Henrik Watz, Stefanie Weber, Markus Weckmann, Nils Welchering, Esther Zeitlmann, Ulrich Zissler   +102 more
doaj   +1 more source