Results 101 to 110 of about 13,066,219 (329)

Predominant Expression of Hybrid N-Glycans Has Distinct Cellular Roles Relative to Complex and Oligomannose N-Glycans [PDF]

International Journal of Molecular Sciences, 2016
Glycosylation modulates growth, maintenance, and stress signaling processes. Consequently, altered N-glycosylation is associated with reduced fitness and disease. Therefore, expanding our understanding of N-glycans in altering biological processes is of utmost interest.
Hall, M. Kristen, Weidner, Douglas A., Zhu, Young, Dayal, Sahil, Whitman, Austin A., Schwalbe, Ruth   +5 more
openaire   +3 more sources

Treatment with Plasma Activated (Salt) Water Sterilizes Macromolecular Coatings While Maintaining Their Integrity and Functionality

Advanced Materials Interfaces, EarlyView.
PDMS samples were covalently coated with mucin glycoproteins and then treated with either plasma activated water (PAW) or saline (PAS) as a means of disinfection. The samples could be successfully sterilized without compromising the structural integrity or functionality of those coatings.
Bernardo Miller Naranjo, Markus Ahrens, Ádám Nemes, Petra Mela, Oliver Lieleg   +4 more
wiley   +1 more source

Non-targeted N-glycome profiling reveals multiple layers of organ-specific diversity in mice

Nature Communications
N-glycosylation is one of the most common protein modifications in eukaryotes, with immense importance at the molecular, cellular, and organismal level.
Johannes Helm, Stefan Mereiter, Tiago Oliveira, Anna Gattinger, David M. Markovitz, Josef M. Penninger, Friedrich Altmann, Johannes Stadlmann   +7 more
doaj   +1 more source

Mutations in four glycosyl hydrolases reveal a highly coordinated pathway for rhodopsin biosynthesis and N-glycan trimming in Drosophila melanogaster. [PDF]

PLoS Genetics, 2014
As newly synthesized glycoproteins move through the secretory pathway, the asparagine-linked glycan (N-glycan) undergoes extensive modifications involving the sequential removal and addition of sugar residues.
Erica E Rosenbaum, Eva Vasiljevic, Kimberley S Brehm, Nansi Jo Colley   +3 more
doaj   +1 more source

Vaccine-Elicited Tier 2 HIV-1 Neutralizing Antibodies Bind to Quaternary Epitopes Involving Glycan-Deficient Patches Proximal to the CD4 Binding Site

PLoS Pathogens, 2015
Eliciting broad tier 2 neutralizing antibodies (nAbs) is a major goal of HIV-1 vaccine research. Here we investigated the ability of native, membrane-expressed JR-FL Env trimers to elicit nAbs.
E. Crooks, T. Tong, B. Chakrabarti, K. Narayan, I. Georgiev, Sergey Menis, Xiaoxing Huang, Daniel W. Kulp, K. Osawa, Janelle Muranaka, Guillaume B. E. Stewart-Jones, J. Destefano, S. O'Dell, C. Labranche, James E. Robinson, D. Montefiori, K. Mckee, S. Du, N. Doria-Rose, P. Kwong, J. Mascola, P. Zhu, W. Schief, R. Wyatt, R. Whalen, J. Binley   +25 more
semanticscholar   +1 more source

Applications and continued evolution of glycan imaging mass spectrometry.

Mass spectrometry reviews (Print), 2021
Glycosylation is an important posttranslational modifier of proteins and lipid conjugates critical for the stability and function of these macromolecules. Particularly important are N-linked glycans attached to asparagine residues in proteins.
Colin T McDowell, Xiaowei Lu, A. Mehta, P. Angel, R. Drake   +4 more
semanticscholar   +1 more source

Rational Design of Optical Single‐Walled Carbon Nanotube‐Based Nanosensors with Biological Recognition Elements

Advanced Sensor Research, EarlyView.
This Review focuses on assessing and providing perspective on the field of rationally‐designed optical sensors constructed with single‐walled carbon nanotubes. The literature is reviewed and evaluated for SWCNT‐based sensors constructed with biomolecular recognition elements, including proteins, peptides, and oligonucleotides, as well as their methods ...
Amelia K. Ryan, Atara Israel, Maria Celina Stefoni, Catarina Ferraz, Ryan M. Williams   +4 more
wiley   +1 more source

Functions of cell surface galectin-glycoprotein lattices [PDF]

, 2007
Programmed remodeling of cell surface glycans by the sequential action of specific glycosyltransferases can control biological processes by generating or masking ligands for endogenous lectins. Galectins, a family of animal lectins with affinity for beta-
Jackson, Shawn S., Rabinovich, Gabriel Adrián, Toscano, Marta Alicia, Vasta, Gerardo R.   +3 more
core   +1 more source

T Cell Glycoengineering to Modulate Immune‐Tumor Crosstalk: A Universal Non‐Genetic Strategy for Enhanced Tumor Immunotherapy

Advanced Science, EarlyView.
This study describes a T cell surface engineering strategy that integrates polymer materials with tumor immunology, aiming to achieve broad‐spectrum anti‐tumor applications of glycopolymer‐engineered T (G‐T) cells via non‐genetic modification. Glycopolymer engineering generally modulates immune‐tumor crosstalk through specific cell‐cell interactions ...
Lihua Yao, He Yang, Fangjian Shan, Xiaomeng Niu, Yichen Wang, Hengyuan Zhang, Sujian Wang, Gaojian Chen, Hong Chen   +8 more
wiley   +1 more source

N-Glycan Branching Decouples B Cell Innate and Adaptive Immunity to Control Inflammatory Demyelination

iScience, 2020
Summary: B cell depletion potently reduces episodes of inflammatory demyelination in multiple sclerosis (MS), predominantly through loss of innate rather than adaptive immunity.
Christie-Lynn Mortales, Sung-Uk Lee, Armen Manousadjian, Ken L. Hayama, Michael Demetriou   +4 more
doaj   +1 more source