Results 251 to 260 of about 13,562,347 (304)

N -glycan and Alzheimer's disease

Biochimica et Biophysica Acta (BBA) - General Subjects, 2017
Alzheimer's disease (AD) is a major form of dementia. Many evidence-based clinical trials have been performed, but no effective treatment has yet been developed. This suggests that our understanding of AD patho-mechanisms is still insufficient. In particular, the pathological roles of posttranslational modifications including glycosylation have ...
Yasuhiko, Kizuka, Shinobu, Kitazume, Naoyuki, Taniguchi   +2 more
openaire   +2 more sources

Separation of N-Glycans by HPLC

2008
Most glycoproteins carry a very heterogeneous mixture of oligosaccharides and even a single glycosylation site of a pure glycoprotein is often heterogeneously glycosylated. The structural diversity of oligosaccharides arises from linkage variants, from differences in the size and number of charges of glycans, and from differences in the monosaccharide ...
Martin, Gohlke, Véronique, Blanchard
openaire   +2 more sources

Chromatographic Profiling of N-Glycans

2019
Most glycoproteins carry a very heterogeneous mixture of oligosaccharides and even a single glycosylation site of a pure glycoprotein is often heterogeneously glycosylated. The structural diversity of oligosaccharides arises from linkage variants, from differences in the size and number of charges of glycans, and from differences in the monosaccharide ...
Martin, Gohlke, Véronique, Blanchard
openaire   +2 more sources

Regulation of integrin functions by N-glycans

Glycoconjugate Journal, 2004
Integrins are cell surface transmembrane glycoproteins that function as adhesion receptors in cell-ECM interactions and link matrix proteins to the cytoskeleton. Integrins play an important role in cytoskeleton organization and in the transduction of intracellular signals, regulating various processes such as proliferation, differentiation, apoptosis ...
Jianguo, Gu, Naoyuki, Taniguchi
openaire   +2 more sources

A draft of human N-glycans of glycoRNA

2023
Abstract In addition to the backbone molecules of proteins and lipids, RNAs have recently been found to be N-glycosylated as well in cell models. Some overlap of N-glycans between RNA and protein exist in terms of monosaccharide composition.
ming bi, Zirui Zhang, Tao Wang, hongwei liang, zhixin tian   +4 more
openaire   +1 more source

Immunogenicity of the N-glycans of peanut peroxidase

Phytochemistry, 1994
The three tryptic glycopeptides of cationic peanut peroxidase (C. PRX) and the sole one of anionic peanut peroxidase (A. PRX) were individually coupled to bovine serum albumin to raise antisera. The three categories of antibodies directed towards three N-glycans of C.
L, Wan, R B, van Huystee
openaire   +2 more sources

N-Glycan processing and glycoprotein folding

2001
Publisher Summary This chapter describes how N-glycan processing participates in the folding and quality control mechanisms operating in the ER. Glycosylation of asparagine residues (N-glycosylation) in the endoplasmic reticulum (ER) presents two basic differences with respect to glycosylation of Ser/Thr residues (Ooglycosylation) in either the ...
E S, Trombetta, A J, Parodi
openaire   +2 more sources

Chemical and enzymatic N-glycan release comparison for N-glycan profiling of monoclonal antibodies expressed in plants

Analytical Biochemistry, 2010
Plants synthesize N-glycans containing the antigenic sugars alpha(1,3)-fucose and beta(1,2)-xylose. Therefore it is important to monitor these N-glycans in monoclonal antibodies produced in plants (plantibodies). We evaluated several techniques to characterize the N-glycosylation of a plantibody produced in tobacco plants with and without the KDEL ...
Triguero, Ada, Cabrera, Gleysin, Royle, Louise, Harvey, David, Rudd, Pauline, Dwek, Raymond, Bardor, Muriel, Lerouge, Patrice, Cremata, José   +8 more
openaire   +3 more sources

N-glycan production in the endoplasmic reticulum of plants

Trends in Plant Science, 2009
N-glycosylation is a complex process that encompasses the biosynthesis and modification of sugar moieties in the endoplasmic reticulum (ER) and Golgi. The ER-localized steps of N-glycan production in plants have received relatively little attention, despite their emerging roles in stress responses.
Richard J, Pattison, Anna, Amtmann
openaire   +2 more sources

Methods for the absolute quantification of N-glycan biomarkers

Biochimica et Biophysica Acta (BBA) - General Subjects, 2016
Many treatment options especially for cancer show a low efficacy for the majority of patients demanding improved biomarker panels for patient stratification. Changes in glycosylation are a hallmark of many cancers and inflammatory diseases and show great potential as clinical disease markers.
Juan, Etxebarria, Niels-Christian, Reichardt   +1 more
openaire   +2 more sources