Results 261 to 270 of about 13,066,219 (329)

Endocrine Resistance Score Based on Three Key Genes Predicts Prognosis and Reveals Potential Therapeutic Targets for ER+HER2− Breast Cancer

Cell Proliferation, EarlyView.
We generated endocrine‐resistant BC cell lines and identified CLEC3A, PCDH10, and ST3GAL1 as key endocrine‐resistant genes. More importantly, we validated their role in mediating resistance through PI3K‐AKT signalling and developed a predictive ERS with strong clinical relevance.
Liqin Ping, Lewei Zhu, Nian Chen, Xikun Liu, Jirui Zhong, Xiaoqing Sun, Hailin Tang, Kaiming Zhang   +7 more
wiley   +1 more source

Evaluating the Impact of N-Glycan Sequon Removal in the p27 Peptide on RSV F Protein Immunogenicity and Functionality. [PDF]

Viruses
Jacobs L, Leemans A, Stobbelaar K, Fransen A, Cos P, Delputte P.   +5 more
europepmc   +1 more source

Influenza A Virus (H1N1) Infection Induces Ferroptosis to Promote Developmental Injury in Fetal Tissues

Cell Proliferation, EarlyView.
H1N1 infection during pregnancy specifically targets the fetal liver and lungs, triggering immune responses, tissue fibrosis and ferroptosis in parenchymal cells, ultimately leading to adverse pregnancy outcomes, offering insights into managing maternal H1N1 infections and their impact on fetal health.
Yuxi Jiang, Yao Shen, Qiongyin Zhang, Zi Liu, Yuzhen Liu, Jiaojiao Peng, Xuesong Yang, Feng Gao, Xiang‐Hong Ou, Qing‐Yuan Sun, Qiao Zhang, Guang Wang   +11 more
wiley   +1 more source

N-Glycan Branching Regulates BTLA Opposite to PD-1 to Limit T Cell Hyperactivity Induced by Branching Deficiency. [PDF]

J Immunol
Mkhikian H, Zhou RW, Saryan H, Sánchez CD, Balakrishnan A, Dang J, Mortales CL, Demetriou M.   +7 more
europepmc   +1 more source

Taxonomic and functional shifts in the microbiome of severely obese, prediabetic patients: Ketogenic diet versus energy‐matched standard diet

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Aims Obesity and type 2 diabetes mellitus (T2DM) are among the leading global health challenges of the 21st century. While caloric restriction remains the cornerstone of weight loss interventions, ketogenic diets (KD), characterised by low carbohydrate and high fat intake, have been shown to improve metabolic health partly by modulating the ...
June Stone, Afroditi Tripyla, Melanie C. Scalise, Maria L. Balmer, Lia Bally, Dominik M. Meinel   +5 more
wiley   +1 more source

PNGaseA-mediated N-glycan stripping from peptides by infant-derived Bifidobacterium bifidum

Bakshani CR, Ojuri TO, Caulton SG, Coughlan K, Bottacini F, Lovering AL, van Sinderen D, Crouch LI.   +7 more
europepmc   +1 more source

The branched N-glycan of PD-L1 predicts immunotherapy responses in patients with recurrent/metastatic HNSCC. [PDF]

Oncogenesis
Huang HC, Huang YL, Chen YJ, Wu HY, Hsu CL, Kao HF, Liao BC, Hsieh MS, Lin NY, Liao YH, Chen HL, Chen CN, Chen TC, Wang CP, Yang TL, Huang MC, Lin MC, Lou PJ.   +17 more
europepmc   +1 more source

Beyond nocardioform: Transcriptionally active microbes and host responses in equine mucoid placentitis

Equine Veterinary Journal, EarlyView.
Abstract Background Nocardioform placentitis (NP) is an understudied form of equine placentitis historically attributed to nocardioform bacteria, yet it remains uncertain whether these organisms are the sole pathogens involved. Objectives To elucidate the pathophysiology of NP and the host–pathogen interaction. Study Design In vivo clinical multi‐omics
Machteld van Heule, Margo Verstraete, Jamie Kaj Norris, Kinga Barbara Graniczkowsa, Kirsten E. Scoggin, Hossam El‐Sheikh Ali, Barry A. Ball, Ward De Spiegelaere, Peter Daels, Bart C. Weimer, Pouya Dini   +10 more
wiley   +1 more source

PNGaseL from Flavobacterium akiainvivens targets a diverse range of N-glycan structures

Bakshani CR, Urbanowicz PA, Tortosa CB, Diaz JMM, Kujawska M, Ojuri TO, Hall LJ, Spencer DI, Bolam DN, Crouch LI.   +9 more
europepmc   +1 more source

Plasma <i>N</i>-Glycan Profiling Enhances Diagnostic Precision in Multiple Sclerosis, AQP4-Ab NMOSD, and MOGAD. [PDF]

Neurol Neuroimmunol Neuroinflamm
Kacerova T, Sealey M, Saldana L, Xiong W, Woodhall MR, Waters PJ, Sénard T, Cheeseman J, Urbanowicz PA, Elgood-Hunt G, Spencer DIR, McCullagh JSO, Leite MI, DeLuca GC, Palace J, Anthony DC, Yeo T, Probert F.   +17 more
europepmc   +1 more source