Results 51 to 60 of about 31,604 (216)

Structure and stereochemistry of the base excision repair glycosylase MutY reveal a mechanism similar to retaining glycosidases. [PDF]

, 2015
MutY adenine glycosylases prevent DNA mutations by excising adenine from promutagenic 8-oxo-7,8-dihydroguanine (OG):A mismatches. Here, we describe structural features of the MutY active site bound to an azaribose transition state analog which indicate a
Cao, Sheng, Chu, Aurea, David, Sheila S, Horvath, Martin P, O'Shea, Valerie L, Richards, Jody L, Woods, Ryan D   +6 more
core   +2 more sources

Dissecting conformational contributions to glycosidase catalysis and inhibition [PDF]

, 2014
Glycoside hydrolases (GHs) are classified into >100 sequence-based families. These enzymes process a wide variety of complex carbohydrates with varying stereochemistry at the anomeric and other ring positions.
Amaya, Andrew J Thompson, Bacik, Biarnes, Bie, Cartmell, Chan, Cremer, Dalziel, Davies, Driguez, Gaetano Speciale, Gideon J Davies, Gloster, Goddard-Borger, Gregg, Hehemann, Heightman, Hill, Hine, Juers, Kim, Koshland, Legler, Lombard, Macauley, Mader, Maita, Martinez-Fleites, Mayes, Money, Mosi, Namchuk, Parenti, Petersen, Planas, Reeves, Rempel, Roeser, Russell, Sabini, Schramm, Shidmoossavee, Sidhu, Sinnott, Sinnott, Sinnott, Spencer J Williams, Stoddart, Tanaka, Tews, Thompson, Thompson, Thompson, Varrot, Varrot, Vavricka, Vincent, Vocadlo, von Itzstein, Wan, Westerik, Williams, Wolfenden, Wolfenden, Zechel, Zhu   +66 more
core   +1 more source

GASdb: a large-scale and comparative exploration database of glycosyl hydrolysis systems [PDF]

, 2010
Background The genomes of numerous cellulolytic organisms have been recently sequenced or in the pipeline of being sequenced. Analyses of these genomes as well as the recently sequenced metagenomes in a systematic manner could possibly lead to ...
Chen, Huiling, Xu, Ying, Zhou, Fengfeng
core   +3 more sources

Genomic and functional analysis of the mucinolytic species Clostridium celatum, Clostridium tertium, and Paraclostridium bifermentans

Frontiers in Microbiology
Mucins are large glycoproteins whose degradation requires the expression of several glycosil hydrolases to catalyze the cleavage of the oligosaccharide chains and release monosaccharides that can be assimilated.
Francesco Candeliere, Eliana Musmeci, Laura Sola, Alberto Amaretti, Alberto Amaretti, Stefano Raimondi, Stefano Raimondi, Maddalena Rossi, Maddalena Rossi   +8 more
doaj   +1 more source

Hispidin and Lepidine E: two Natural Compounds and Folic acid as Potential Inhibitors of 2019-novel coronavirus Main Protease (2019-nCoVMpro), molecular docking and SAR study [PDF]

arXiv, 2020
2019-nCoV is a novel coronavirus was isolated and identified in 2019 in Wuhan, China. On 17th February and according to world health organization, a number of 71 429 confirmed cases worldwide, among them 2162 new cases recorded in the last 24 hours. There is no drug or vaccine for human and animal coronavirus.
arxiv  

Recent Advances in Enzymes and Chemoenzymatic Synthesis of Tetrasaccharide Linkage Region of Proteoglycans

ChemBioChem, EarlyView.
The tetrasaccharide linkage region of proteoglycans is synthesized through a series of well‐controlled enzymatic reactions in nature. The expression, activity, and substrate profile of these biosynthetic enzymes and the latest development of chemoenzymatic synthesis of linkage region‐bearing glycopeptides are summarized in this review.
Po‐han Lin, Xuefei Huang
wiley   +1 more source

Stereochemical course of the hydrolysis reaction catalyzed by chitinases Al and D from Bacillus circulans WL-12 [PDF]

, 1994
Chitinases A1 and D were purified from the periplasmic proteins produced by Escherichia coli HB101 harbouring recombinant plasmids carrying respectively the chiA and chiD genes of Bacillus circulans WL-12.
Armand, S., Gey, C., Henrissat, B., Heyraud, A., Tomita, H., Watanabe, T.   +5 more
core   +2 more sources

Stereoselective Synthesis of 1,2‐cis‐α‐Glycosyl Thiols and Trehalose‐Type α,α’‐Thiodisaccharides by Cryo Thiol‐Ene Photocoupling – Thio‐Click Reaction in Frozen State

Chemistry – A European Journal, Volume 31, Issue 20, April 4, 2025.
A double photochemical cryo thiol‐ene coupling process was developed as a general method for the synthesis of 1,2‐cis‐α,α’‐thio‐linked di‐ and oligosaccharides. The procedure includes i) UV‐initiated coupling reaction of 2‐substituted glycals with HSAc in AcOH at −80 °C in frozen state, ii) selective S‐deacetylation of the resulting glycosyl‐α‐SAc ...
Viktor Kelemen, Miklós Bege, Nóra Debreczeni, Ilona Bereczki, Attila Csaba Bényei, Pál Herczegh, Anikó Borbás   +6 more
wiley   +1 more source

Conserved catalytic machinery and the prediction of a common fold for several families of glycosyl hydrolases.

Proceedings of the National Academy of Sciences of the United States of America, 1996
The regions surrounding the catalytic amino acids previously identified in a few "retaining" O-glycosyl hydrolases (EC 3.2.1) have been analyzed by hydrophobic cluster analysis and have been used to define sequence motifs. These motifs have been found in
B. Henrissat, Isabelle, CALLEBAUTt, S. Fabrega, P. Lehn, Jean-Paul, MORNONt, Gideon Daviess   +7 more
semanticscholar   +1 more source

Sustainable and Scalable Enzymatic Production, Structural Elucidation, And Biological Evaluation of Novel Phlorizin Analogues

ChemSusChem, Volume 18, Issue 8, April 14, 2025.
New α‐glycosides of chalcones and dihydrochalcones, analogues of naturally occurring phlorizin, have been synthesized using a CGTase‐catalyzed glycosylation that was successfully scaled‐up in a 10‐liter reactor. The α‐glycosides were (i) purified using an original centrifugal partition chromatography technique, (ii) characterized through NMR and LC–MS ...
Laurène Minsat, Yueying Li, Cédric Peyrot, Agathe Martinez, Nicolas Borie, Aurélien Peru, Blandine Godon, Clément Nève, Fanny Brunissen, Fanny Brunois, Abdouramane Dosso, Florent Allais, Jean‐Hugues Renault   +12 more
wiley   +1 more source