Results 61 to 70 of about 12,728 (171)

Substrate scope of ancestral versus modern family‐1 glycosidases

Protein Science, Volume 35, Issue 7, July 2026.
Abstract Experimental studies support that protein engineering based on ancestral sequence reconstruction often leads to variants with biotechnologically useful biomolecular properties. These may include high stability, enhanced conformational flexibility and a modified catalysis range.
Luis I. Gutierrez‐Rus, Dušan Petrović, Pascal Schneider, Katja Zorn, Gloria Gamiz‐Arco, Rocío Romero‐Zaliz, Ignacio Suarez‐Martin, Leonardo De Maria, Francesco Falcioni, Valeria A. Risso, Martin A. Hayes, Jose M. Sanchez‐Ruiz   +11 more
wiley   +1 more source

A multilayered regulatory framework linking cell wall remodelling, redox homeostasis, and metabolic plasticity during leaf development in Arabidopsis thaliana

Annals of Applied Biology, Volume 189, Issue 1, July 2026.
This study proposes a three‐layered regulatory model illustrating the transition from cell wall remodelling to redox homeostasis during leaf maturation. The model integrates structural extensibility (CESA8, XTH15), redox‐metabolic balancing (AOX1A), and transcriptional feedback mediated by NAC13.
Bayram Ali Yerlikaya
wiley   +1 more source

Discovery, Functional Genomics and Biochemical Characterization of Alpha-specific Glycosyl Hydrolases from Hyperthermophilic Microorganisms

, 2007
Glycosyl hydrolases — biocatalysts that are capable of hydrolyzing linkages between sugars — comprise a significant fraction of the current industrial enzyme market and are used in applications ranging from baking and brewing, to bioenergy ...
Comfort, Donald Andrew
core  

Direct Competitive Kinetic Isotope Effect Measurement Using Quantitative Whole Molecule Matrix‐Assisted Laser Desorption Ionization Time‐of‐Flight Mass Spectrometry

ChemBioChem, Volume 27, Issue 12, 26 June 2026.
Kinetic Isotope effect (KIE) measurements are a powerful tool to interrogate enzyme mechanisms and transition state structures. In this study, we develop a simple quantitative MALDI‐TOF mass spectrometry approach to measure competitive heavy atom KIEs.
Teodora Kljaic, Merritt A. Scott, Veronica Guirguis, Michal Tyrlik, Andrew Liu, Myles B. Poulin   +5 more
wiley   +1 more source

Applications in Biocatalysis of Glycosyl Hydrolases from the Hyperthermophilic Archaeon Sulfolobus solfataricus

, 2003
Carbohydrates serve as structural components and en- ergy sources of cells. More interestingly, however, these biomolecules are involved in a variety of molecular recognition processes in intercellular communication and signal transduction such as cell ...
DI LAURO, BARBARA, MORACCI, Marco, PERUGINO, GIUSEPPE, Trincone, Antonio, Giordano, Assunta, Mazzone, Marialuisa, Cobucci Ponzano, Beatrice, ROSSI, MOSE'   +7 more
core   +1 more source

Chitin-binding function and glycosyl hydrolysis/motor-like system facilitate the spread of the wheat mosaic virus

, 2022
Infecting cereals and grasses worldwide, wheat mosaic disease poses a serious risk to food security. The major grain producing regions have been threatened by major crop diseases and insect pests.
wenzhong, liu, hualan, li
core   +1 more source

Characterization of glycosyl hydrolases involved in plant biomass degradation

, 2022
Em virtude da crescente demanda por energia e de problemas ambientais causados pelo consumo de combustíveis fósseis, tem-se aumentado a necessidade de produção de combustíveis renováveis.
Melo, Vandierly Sampaio de
core   +1 more source

Structural Basis for Nucleobase Activation by the Adenine DNA Glycosylase MutY

ChemBioChem, Volume 27, Issue 11, 15 June 2026.
DNA glycosylase MutY engages its adenine nucleobase substrate in a syn orientation with a catalytic Glu. X‐ray crystal structures of MutY with Glu replaced suggest that a disengaged “on hold” state with anti nucleobase orientation may explain how MutY avoids catastrophic activity at inappropriate adenines.
L. Peyton Russelburg, Merve Demir, Karina Cedeno, Sheila S. David, Martin P. Horvath   +4 more
wiley   +1 more source

N‐Glycosyl Triazoline Glycomimetics via Huisgen Cycloaddition With an Electron‐Deficient Alkene and BF3‐Catalysed Triazoline Fragmentation to Aziridines

European Journal of Organic Chemistry, Volume 29, Issue 22, 9 June 2026.
Glycomimetics with triazoline and aziridine groups were synthesised via diastereoselective Huisgen cycloaddition from glycosyl azides. Density functional theory was applied to define the mechanism for BF3 promoted aziridine formation. Triazoline and aziridine derivatives were synthesised by diastereo‐ and regioselective Huisgen cycloaddition of 2,3,4,6‐
Aaron McCormack, Ashis Dhara, Lamis Alaa Eldin Refat, Mikael Bols, Paul V. Murphy   +4 more
wiley   +1 more source

Evaluate the Prognostic Value of serumγKlotho on Long‐Term Prognosis of Patients With Multivessel Coronary Artery Disease and Establish a Prognostic Model

Clinical Cardiology, Volume 49, Issue 6, June 2026.
Higher serum γKlotho level correlated with the poor prognosis of MVD patients, our predictive model exhibited better predictive ability and clinical usefulness. ABSTRACT Objective This study was aimed at analyzing the correlation of serum γKlotho with the long‐term prognosis of multivessel coronary artery disease (MVD) and develop a predictive model to
Tuersunjiang Naman, Yu‐ting Zhang, Ayinuer Maihemuti, Hui Cheng, Wen‐bo Fu, Xiao‐lin Yu, Zhao Wang, Yi‐ning Yang, Zi‐tong Guo   +8 more
wiley   +1 more source