Results 51 to 60 of about 623,633 (264)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Uniquely decodable n-gram embeddings

Theoretical Computer Science, 2004
Abstract: "We define the family of n-gram embeddings from strings over a finite alphabet into the semimodule N[superscript K]. We classify all [xi] [element of] N[superscript K] that are valid images of strings under such embeddings, as well as all [xi] whose inverse image consists of exactly 1 string (we call such [xi] uniquely decodable).
openaire   +2 more sources

A Novel Deep-Learning-Based Bug Severity Classification Technique Using Convolutional Neural Networks and Random Forest with Boosting

Sensors, 2019
The accurate severity classification of a bug report is an important aspect of bug fixing. The bug reports are submitted into the bug tracking system with high speed, and owing to this, bug repository size has been increasing at an enormous rate.
Ashima Kukkar, Rajni Mohana, Anand Nayyar, Jeamin Kim, Byeong-Gwon Kang, Naveen Chilamkurti   +5 more
doaj   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

Feature Selection to Enhance DDoS Detection Using Hybrid N-Gram Heuristic Techniques

JOIV: International Journal on Informatics Visualization, 2023
Various forms of distributed denial of service (DDoS) assault systems and servers, including traffic overload, request overload, and website breakdowns.
Andi Maslan, Kamaruddin Malik Bin Mohamad, Abdul Hamid, Hotma Pangaribuan, Sunarsan Sitohang   +4 more
doaj   +1 more source

Bayesian Grammar Induction for Language Modeling

, 1995
We describe a corpus-based induction algorithm for probabilistic context-free grammars. The algorithm employs a greedy heuristic search within a Bayesian framework, and a post-pass using the Inside-Outside algorithm.
Chen, Stanley F.
core   +3 more sources

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien   +35 more
wiley   +1 more source

Automatic document summarization based on statistical information

Вестник КазНУ. Серия математика, механика, информатика, 2017
Actual problem in nowadays is to efficiently process the large amount of data that pass through our mind everyday. The object of study of this paper is automatic summarization algorithms.
A. Mussina, S. Aubakirov, D. Ahmed-Zaki, P. Trigo   +3 more
doaj  

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source