Results 51 to 60 of about 14,339,869 (296)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Vancomyxins: Vancomycin-Polymyxin Nonapeptide Conjugates That Retain Anti-Gram-Positive Activity with Enhanced Potency against Gram-Negative Strains

, 2021
Vancomycin functions by binding to lipid II, the penultimate bacterial cell wall building block used by both Gram-positive and Gram-negative species.
Paolo Innocenti (228808), Nathaniel I. Martin, Emma van Groesen, Emma van Groesen (11417127), Milos Mihajlovic (11417130), Rosalinde Masereeuw (180563), Cornelis J. Slingerland, Rosalinde Masereeuw, Milos Mihajlovic, Paolo Innocenti, Cornelis J. Slingerland (2796262), Nathaniel I. Martin (847378)   +11 more
core   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Linear levels through n-grams [PDF]

Proceedings of the 18th International Academic MindTrek Conference: Media Business, Management, Content & Services, 2014
We show that novel, linear game levels can be created using n-grams that have been trained on a corpus of existing levels. The method is fast and simple, and produces levels that are recognisably in the same style as those in the corpus that it has been trained on. We use Super Mario Bros.
Steve Dahlskog, Julian Togelius, Mark J. Nelson   +2 more
openaire   +2 more sources

A Novel Deep-Learning-Based Bug Severity Classification Technique Using Convolutional Neural Networks and Random Forest with Boosting

Sensors, 2019
The accurate severity classification of a bug report is an important aspect of bug fixing. The bug reports are submitted into the bug tracking system with high speed, and owing to this, bug repository size has been increasing at an enormous rate.
Ashima Kukkar, Rajni Mohana, Anand Nayyar, Jeamin Kim, Byeong-Gwon Kang, Naveen Chilamkurti   +5 more
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Statistical machine translation implementation and performance tests betweenKyrgyz and Turkish Languages

MANAS: Journal of Engineering, 2015
Bilgisayarlı çeviri, doğal diller arası metin çevirmede kullanılan farklı yöntem ve yazılımları araştırmayı amaçlayan bilgisayarlı dilbilim alt alanıdır.
N. Tayirova, M. Tekerek, U. Brimkulov
doaj  

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

N-Gram against the Machine: On the Feasibility of the N-Gram Network Analysis for Binary Protocols

, 2012
In recent years we have witnessed several complex and high-impact attacks specifically targeting "binary" protocols (RPC, Samba and, more recently, RDP). These attacks could not be detected by current – signature-based – detection solutions, while – at least in theory – they could be detected by state-of-the-art anomaly-based systems.
Dina Hadziosmanovic, Lorenzo Simionato, Damiano Bolzoni, Emmanuele Zambon, Sandro Etalle   +4 more
openaire   +4 more sources

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source