Results 51 to 60 of about 15,695,648 (130)

Stereoselective Syntheses of l-Pipecolic Acid and (2S,3S)-3-Hydroxypipecolic Acid from a Chiral N-Imino-2-phenyl-1,2-dihydropyridine Intermediate

, 2016
Stereoselective syntheses of l-pipecolic acid and (2S,3S)-3-hydroxypipecolic acid were achieved from a chiral N-imino-2-phenyl-1,2-dihydropyridine intermediate.
André B. Charette (1446916), Alexandre Lemire (2310922)   +1 more
core   +1 more source

Alternative Approaches and Plant‐Based Remedies for Livestock Health Management Among the Batswana of Southern Africa: A Review

Chemistry &Biodiversity, Volume 23, Issue 4, April 2026.
ABSTRACT Due to limited access to, and the high cost of conventional veterinary services, Batswana communities often rely on ethnoveterinary practices for livestock health management. This review provides an in‐depth analysis on the ethnoveterinary uses, biological properties and safety assessment of plants utilised in livestock husbandry. A systematic
Tswelelopele G. Mpolokeng, Ndzalama Shikwambana, Mompati V. Chakale, John A. Asong, Lyndy J. McGaw, Stephen O. Amoo, Nqobile A. Masondo, Adeyemi O. Aremu   +7 more
wiley   +1 more source

Making Blank Faces Expressive: Chemical Approaches to the Modification of Chemically Inert Peptides

Journal of Peptide Science, Volume 32, Issue 3, March 2026.
As an alternative to the conventional approach, which combines amino acid monomers in a one‐by‐one fashion to peptide derivatives, the chemical modification of existing peptides has attracted significant attention in recent years. However, such approaches generally target the reactive functional groups in cysteine and lysine residues, particularly in ...
Yoshitaka Moriyama, Hikari Sada, Takeshi Nanjo   +2 more
wiley   +1 more source

6‑Alkynyl- and 6‑Aryl-Substituted (R)‑Pipecolic Acid Derivatives

, 2016
(R)-α-Aminoadipic acid is a readily available enantiomerically pure starting material for the synthesis of (R)-pipecolic acid and its derivatives. Sonogashira or Suzuki cross-coupling reactions of an N-formyl pipecolate-derived vinyl bromide furnish 6 ...
Norbert Sewald (542162), Amina Sadiq (1951162)   +1 more
core   +1 more source

Nicotiana benthamiana as a Production Platform for Artemisinin Precursors [PDF]

, 2010
Background Production of pharmaceuticals in plants provides an alternative for chemical synthesis, fermentation or natural sources. Nicotiana benthamiana is deployed at commercial scale for production of therapeutic proteins.
Herpen, T.W.J.M., van, Nogueira, M., Teun W J M van Herpen, van Herpen Teun W. J. M., Harro J. Bouwmeester, Cankar, Katarina, Katarina Cankar, Harpen, Teun W. J. M. van, Marilise Nogueira, Dirk Bosch, Harro J Bouwmeester, Bouwmeester Harro J., Beekwilder, Jules, Jules Beekwilder, Teun W. J. M. van Herpen, Nogueira Marilise, Cankar, K., van Herpen, T.W.J.M., Cankar Katarina, Beekwilder Jules, Bouwmeester, Harro, Nogueira, Marilise, Bosch, H.J., Bosch Dirk, Bouwmeester, H.J., Beekwilder, M.J., Bosch, Dirk   +26 more
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Synthesis of Substituted Cyclic Amines From Protected Amino Acids Using Oxidative Decarboxylation and Alkylation

Asian Journal of Organic Chemistry, Volume 15, Issue 2, February 2026.
Simple access to alkylated 3D scaffold via oxidative radical decarboxylation, trapping of iminium, and successive reaction with organometallic reagent in the presence of BF3 . ABSTRACT Cyclic amines are vital scaffolds in bioactive molecules and drug discovery, often functionalized via electrochemical Shono‐type oxidation to access N‐acyliminium ...
Dario Corbisiero, Arthur F. Rossignol, Francesco Calogero, Andrea Gualandi, Emanuele Pinosa, Luca Sensoli, Paolo Ronchi, Pier Giorgio Cozzi   +7 more
wiley   +1 more source

Treatment of pediatric epilepsy

Pediatric Investigation, Volume 10, Issue 1, Page 86-100, February 2026.
Anti‐seizure medications are the first‐line treatment for the vast majority of children with epilepsy, with the advantages of non‐invasive wide adaptability. Surgery is the main treatment for drug‐resistant epilepsy and lesion‐related epilepsy, which can cure some cases of epilepsy in children. A ketogenic diet is often an add‐on therapy.
Junxiao Li, Tinghong Liu, Chang Liu, Jie Deng, Shijie Wu, Suhui Kuang, Xiaotong Li, Zhirong Wei, Shuli Liang   +8 more
wiley   +1 more source

Synthesis of High Value 4-hydroxy and 4-oxo Pipecolic Acid Derivatives from a Process Byproduct

, 2009
vi, 22 p.Functional transformations of4-substituted pipecolic acid derivatives are described. Many 4-substituted pipecolic acid derivatives are found throughout nature and within many pharmaceutical targets. The goal of this research involved recycling a
Newcomb, Eric
core   +1 more source

Enantioselective Diels−Alder Reactions with N-Hydroxy-N-phenylacrylamide

, 2016
The use of hydroxamic acids as templates for Lewis acid catalyzed enantioselective Diels−Alder reactions has been examined. A very simple chiral Lewis acid, prepared by mixing optically pure binaphthol with 3 equiv of trimethylaluminum, catalyzes the [4 +
Philippe Renaud (201179), Olivier Corminboeuf (2358277)   +1 more
core   +1 more source

Pipecolic acid as a diagnostic marker of pyridoxine-dependent epilepsy.

, 2005
Pyridoxine-dependent epilepsy, although described some decades ago, may still be an underdiagnosed disorder. We have recently described isolated pipecolic acid elevations in the plasma and/or CSF of three patients with pyridoxine-dependent epilepsy with ...
Plecko, B;Hikel, C;Korenke, GC;Schmitt, B;Baumgartner, M;Baumeister, F;Jakobs, C;Struys, E;Erwa, W;Stöckler-Ipsiroglu, S
core   +1 more source