Results 31 to 40 of about 15,695,648 (130)

Investigating the Effect of Pipecolic Acid on Specialized Metabolites Involved in Tomato Plant Defense Mechanisms Against Ralstonia solanacearum Wilt Pathogens

Analytica
The role of pipecolic acid (Pip) in plant immune responses, particularly against bacterial wilt pathogens, is significant. This research aimed to understand the interaction between plant defense-responsive enzymes and Pip by analyzing methanolic extracts
Usha Sabharwal, Piyush Kant Rai, Kamlesh Choure, R. B. Subramanian, Jeong Chan Joo, Ashutosh Pandey   +5 more
doaj   +1 more source

Perturbation of Spermine Homoeostasis Uncouples Hypersensitive Cell Death From Systemic Plant Immunity

Plant, Cell &Environment, EarlyView.
ABSTRACT Polyamines are key regulators of plant stress responses, yet their contribution to coordinating local immune responses with systemic immunity remains poorly understood. Here, we investigated how spermine (Spm) homeostasis influences local and systemic defence responses in Arabidopsis thaliana following inoculation with Pseudomonas syringae pv.
Jiaqi Zhao, Kostadin E. Atanasov, Olga Jauregui, Rubén Alcázar   +3 more
wiley   +1 more source

Polyphenol‐Rich Foods as a Healthy and Sustainable Strategy: Mental Health and Metabolomic Profiling

Molecular Nutrition &Food Research, Volume 70, Issue 19, 15 October 2026.
A 12‐week nutritional intervention with cocoa flavanols and red‐berry anthocyanins in older adults improved emotional well‐being and identified metabolomic signatures associated with the intervention through urinary metabolome profiling. ABSTRACT The so‑called demographic transition has increased the prevalence of chronic diseases in adults over 65 ...
María Lucía Gómez Nieto, Verónica Puertas‐Martín, Susana Chamorro, Antonio Méndez‐Guerrero, Inmaculada Álvarez‐Acero, Claudia Balderas, Sonia de Pascual‐Teresa   +6 more
wiley   +1 more source

Enantioselective Synthesis of Substituted Pipecolic Acid Derivatives

, 2016
Enantiomerically pure 4-piperidones, prepared by asymmetric [4 + 2] Diels−Alder cycloadditon of chiral 2-aminodienes with imines, have been used as starting materials for the synthesis of several derivatives of pipecolic acid.
Fernando Aznar (2087200), Cristina Ribas (3040539), José Barluenga (268140), Carlos Valdés (2473141)   +3 more
core   +1 more source

Metabolomics Based Biomarkers of Green Beans Intake

Molecular Nutrition &Food Research, Volume 70, Issue 19, 15 October 2026.
Identification of urinary food intake biomarkers of green beans using metabolomics applied to time response and dose response studies.This image was created with BioRender.com. ABSTRACT While there is considerable interest in legumes as a food source, there are no validated biomarkers for green beans (Phaseolus vulgaris, L.) intake.
Rebecca Finlay, Ya Gao, Qi Sun, Frank Hu, Jayne Woodside, Xiaofei Yin, Lorraine Brennan   +6 more
wiley   +1 more source

Advances in large DNA fragment assembly for microbial cell factory engineering

Quantitative Biology, Volume 14, Issue 3, September 2026.
Abstract The efficient, rapid, and reliable assembly of DNA fragments is essential for advancing metabolic engineering and synthetic biology. With the rapid advancement of DNA synthesis and assembly technologies, the scale of DNA assembly has expanded from single genes to metabolic pathways and even genomes.
Yu Zhang, Wenqian Liu, Dongyuan Cheng, Jiazhang Lian, Xian Fu, Yue Shen   +5 more
wiley   +1 more source

Dengue Virus Molecular Targets and Antiviral Drug Development: Advances, Challenges and Therapeutic Perspectives

ChemistrySelect, Volume 11, Issue 33, 1 September 2026.
This narrative review analyzes DENV molecular targets, including structural proteins (C, prM/M, E), non‐structural components (NS1NS5), and host factors, alongside small‐molecule candidates in preclinical and clinical phases. Owing to high structural conservation, the NS2B‐NS3 protease and NS5 (RdRp/MTase) remain primary drug discovery focuses, while ...
Aryane Lucia da Silva Aguiar De Oliveira, José Arion Da Silva Moura, Pedro César de Souza, Marcelo Arthur Dias da Costa Santana, Matheus Vinicius Guimarães de Melo, Douglas Carvalho Francisco Viana, Marina Galdino Da Rocha Pitta, Isabella Luiza Ralph de Oliveira, Maira Galdino Da Rocha Pitta   +8 more
wiley   +1 more source

Chemoenzymatic Synthesis of Both Enantiomers of cis-6-(Hydroxymethyl)- and cis,cis-4-Hydroxy-6-(hydroxymethyl)pipecolic Acids

, 2016
Both enantiomers of cis-6-(hydroxymethyl)- and cis,cis-4-hydroxy-6-(hydroxymethyl)pipecolic acids, piperidine-based nonproteinogenic amino acids, have been synthesized from starting materials obtained from enzymatic ...
Robert Chênevert (720311), Marie-Pascale Morin (3046983)   +1 more
core   +1 more source

6-Alkynyl- and 6-Aryl-Substituted (R)-Pipecolic Acid Derivatives

, 2013
Sadiq A, Sewald N. 6-Alkynyl- and 6-Aryl-Substituted (R)-Pipecolic Acid Derivatives. Organic Letters. 2013;15(11):2720-2722.(R)-alpha-Aminoadipic acid is a readily available enantiomerically pure starting material for the synthesis of (R)-pipecolic acid ...
Sadiq, Amina, Sewald, Norbert ; https://orcid.org/   +1 more
core   +1 more source

Pharmacokinetics and concentration-effect relationship of oral LSD in humans [PDF]

, 2015
BACKGROUND: The pharmacokinetics of oral lysergic acid diethylamide are unknown despite its common recreational use and renewed interest in its use in psychiatric research and practice.
Dolder, Patrick C., Rentsch, Katharina M., Liechti, Matthias E., Schmid, Yasmin, Haschke, Manuel   +4 more
core   +1 more source