Results 11 to 20 of about 15,695,648 (130)

N-hydroxy-pipecolic acid is a mobile signal that induces systemic disease resistance in Arabidopsis [PDF]

, 2018
Abstract Systemic acquired resistance (SAR) is a global response in plants induced at the site of infection that leads to long-lasting and broad-spectrum disease resistance at distal, uninfected tissues. Despite the importance of this priming mechanism, the identity of the mobile defense signal that moves systemically
Chen, Yun Chu, Holmes, Eric C., Rajniak, Jakub, Kim, Jung-Gun, Tang, Sandy, Fischer, Curt R., Mudgett, Mary Beth, Sattely, Elizabeth S.   +7 more
openaire   +2 more sources

Chromatin-Remodeling Factor CHR5 Promotes Defense Gene Expression and SA Accumulation [PDF]

Plants
Chromatin remodelers play essential roles in modulating nucleosome structure and enabling dynamic transcriptional control. Arabidopsis calmodulin-binding transcription activators CAMTA1/2/3 negatively regulate plant immunity by suppressing the expression
Xueru Liu, Ning Cui, Zhengxi Gong, Hainan Tian, Yuelin Zhang, Xin Li   +5 more
doaj   +2 more sources

Ethnopharmacological Evaluation of a Wild Ecotype of Syzygium cumini (L.) Skeels (Jamoya) Fruit. [PDF]

Chem Biodivers
The phytochemical and biological activity of Syzygium cumini (ecotype) fruit pulp and seed extracts using GC‐MS, UHPLC‐QTOF‐MS, and antidiabetic potential. ABSTRACT The wild ecotype of Jamun (Syzygium cumini) is known for its inedible fruits that are not yet explored for their bioactive potential. The present study assesses the ethnopharmacological and
Sharma R, Pal U, Singh JK, Tanwar M, Gupta RK.   +4 more
europepmc   +2 more sources

Systemic acquired resistance: an emerging role for jasmonates in local signal biogenesis, translocation and distal signal decoding. [PDF]

New Phytol
Jasmonate signalling underpins establishment of plant systemic acquired resistance (SAR). Activation of the hypersensitive response (HR) not only contains the pathogen but establishes broad spectrum resistance in unchallenged leaves. The strong burst of reactive oxygen/nitrogen species initiating the HR results in lipid peroxidation (illustrated by ...
Bennett F, Stroud E, Kachroo P, Grant M.
europepmc   +2 more sources

Actinomycin Derivatives: Structural Diversification and Biological Activities. [PDF]

ChemMedChem
Actinomycins are chromopeptide antibiotics exhibiting remarkable structural diversity and broad bioactivity. This review traces their development from naturally occurring D‐, X‐, A‐, G‐, Y‐, and Z‐type analogs to precursor‐directed, synthetic, and semisynthetic derivatives.
Can Ö, Bedir E.
europepmc   +2 more sources

Why Do High-Risk Patients Develop or Not Develop Coronary Artery Disease? Metabolic Insights from the CAPIRE Study

Metabolites, 2022
Traditional cardiovascular (CV) risk factors (RFs) and coronary artery disease (CAD) do not always show a direct correlation. We investigated the metabolic differences in a cohort of patients with a high CV risk profile who developed, or did not develop,
Martino Deidda, Antonio Noto, Christian Cadeddu Dessalvi, Daniele Andreini, Felicita Andreotti, Eleuterio Ferrannini, Roberto Latini, Aldo P. Maggioni, Marco Magnoni, Giuseppe Mercuro, on behalf of the CAPIRE Investigators   +10 more
doaj   +1 more source

A plant-centric view of class B flavin-dependent monooxygenase evolution and diversity. [PDF]

Plant J
SUMMARY Flavin‐dependent monooxygenases (FMOs) are ancient enzymes present throughout all kingdoms of life. FMOs utilize flavin‐based cofactors to incorporate an oxygen atom into their substrate, altering its chemical properties. Class B FMOs are enriched throughout the plant kingdom, catalyzing essential reactions for plant development and defense ...
Christensen JM, Neilson EHJ.
europepmc   +2 more sources

Microbial‐derived Exerkines preserve muscle size and function during disuse in aged mice in a sex‐dependent manner [PDF]

Physiol Rep
Abstract Disuse‐induced muscle atrophy is a critical clinical challenge in older adults. Existing countermeasures have largely failed to preserve muscle size and function, underscoring the need for novel therapeutic strategies. We recently identified pipecolic acid and succinate (PAS) as microbial‐derived exerkines that prevent disuse‐induced atrophy ...
Daredia J, Valentino T, Ismaeel A, Wen Y, McCarthy J, Burke B.   +5 more
europepmc   +2 more sources

A Novel Multimodal LC-MS/MS Panel for the Comprehensive Diagnosis of Neurometabolic Disorders in CSF. [PDF]

J Inherit Metab Dis
ABSTRACT Metabolic testing of cerebrospinal fluid (CSF) is essential for early diagnosis of neurometabolic disorders. However, the large number of differential diagnoses, the phenotypic variance within a clinical picture, and the disease rarity complicate targeted metabolic diagnostics.
Christ S, Rossmann J, Richter S, Garbade S, Klinke G, Blau N, Hoffmann GF, Okun JG, Opladen T.   +8 more
europepmc   +2 more sources

A NAC Triad Mediates Plant Immunity by Negatively Regulating N-Hydroxy Pipecolic Acid Biosynthesis

, 2023
Abstract N-hydroxy-pipecolic acid (NHP) plays an important role in plant immunity. In contrast to its biosynthesis, our current knowledge with respect to the transcriptional regulation of the NHP pathway is limited. This study commenced with the engineering of Arabidopsis plants that constitutively produce high NHP levels and display enhanced ...
Asaph Aharoni, Jianghua Cai, Sayantan Panda, Yana Kazachkova, Eden Amzallag, Sagit Meir, Ilana Rogachev   +6 more
openaire   +1 more source