Regulation of Salicylic Acid and N-Hydroxy-Pipecolic Acid in Systemic Acquired Resistance [PDF]
The Plant Pathology Journal, 2023 In plants, salicylic acid (SA) is a central immune signal that is involved in both local and systemic acquired resistance (SAR). In addition to SA, several other chemical signals are also involved in SAR and these include N-hydroxy-pipecolic acid (NHP ...
Gah-Hyun Lim
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An Artificial Pathway for N-Hydroxy-Pipecolic Acid Production From L-Lysine in Escherichia coli [PDF]
Frontiers in Microbiology, 2022 N-hydroxy-pipecolic acid (NHP) is a hydroxylated product of pipecolic acid and an important systemic acquired resistance signal molecule. However, the biosynthesis of NHP does not have a natural metabolic pathway in microorganisms.
Zhou Luo +10 more
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Pipecolic Acid Quantification Using Gas Chromatography-coupled Mass Spectrometry [PDF]
Bio-Protocol, 2020 Pipecolic acid (Pip), a non-proteinacious product of lysine catabolism, is an important regulator of immunity in plants and humans alike. For instance, Pip accumulation is associated with the genetic disorder Zellweger syndrome, chronic liver diseases ...
Keshun Yu, huazhen liu, Pradeep Kachroo
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Intracerebroventricular Injection of L-Pipecolic Acid Exerts Hypnotic Effects Without Activating NMDA Receptors in Neonatal Chicks under Social Isolation-induced Stress [PDF]
The Journal of Poultry Science, 2020 L-Pipecolic acid is an intermediate of L-lysine catabolism. Its central injection exerted a hypnotic effect on the brain, which was partially mediated by the activation of γ-aminobutyric acid-A and γ-aminobutyric acid-B receptors. L-Proline has also been
Asako Shigemura +2 more
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New Metabolic Alterations and A Predictive Marker Pipecolic Acid in Sera for Esophageal Squamous Cell Carcinoma [PDF]
Genomics, Proteomics & Bioinformatics, 2022 Esophageal squamous cell carcinoma (ESCC) is a major histological subtype of esophageal cancer with a poor prognosis. Although several serum metabolomic investigations have been reported, ESCC tumor-associated metabolic alterations and predictive ...
Lei Liu +14 more
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In Vitro Fertilisation of Mouse Oocytes in L-Proline and L-Pipecolic Acid Improves Subsequent Development [PDF]
Cells, 2021 Exposure of oocytes to specific amino acids during in vitro fertilisation (IVF) improves preimplantation embryo development. Embryos fertilised in medium with proline and its homologue pipecolic acid showed increased blastocyst formation and inner cell ...
Tamara Treleaven +4 more
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Development of Novel Proline- and Pipecolic Acid-Based Allosteric Inhibitors of Dengue and Zika Virus NS2B/NS3 Protease [PDF]
PharmaceuticalsBackground: In this study, we report a novel series of proline- and pipecolic acid-based small molecules designed as allosteric inhibitors of the NS2B/NS3 serine proteases from dengue and Zika viruses, key targets in antiviral drug discovery.
Josè Starvaggi +10 more
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A Novel Role of Pipecolic Acid Biosynthetic Pathway in Drought Tolerance through the Antioxidant System in Tomato [PDF]
Antioxidants, 2021 With global warming and water shortage, drought stress is provoking an increasing impact on plant growth, development, and crop productivity worldwide.
Ping Wang +8 more
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Expanding metabolic pathway for de novo biosynthesis of the chiral pharmaceutical intermediate l-pipecolic acid in Escherichia coli [PDF]
Microbial Cell Factories, 2017 Background The six-carbon circular non-proteinogenic compound l-pipecolic acid is an important chiral drug intermediate with many applications in the pharmaceutical industry.
Hanxiao Ying +6 more
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Identification of Endogenous Substances Involved in Sclareol-Induced Chlorophyll Reductions in Arabidopsis [PDF]
PlantsSclareol, a natural diterpene, exhibits diverse physiological activities in plants, microorganisms, and animals. Exogenous application of sclareol to Arabidopsis thaliana leaves induces chlorosis-like symptoms accompanied by a reduction in chlorophyll ...
Asma Ben Hmidene, Shigemi Seo
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